The hemorrheological changes were observed in dogs in the first 2 hours after they were inflicted with oleic acid-induced RDS.It was found that hematocrit,absolute viscosity and relative viscosity of whole blood were significantly increased but plasma viscosity showed no marked changes.These facts imply that in the early stage of oleic acid-induced RDS,the hemorrheological changes were characterized by hemoconcentration and decrease of the trans-formability of erythrocytes,which might be one of causes of the functional failure of pulmonary microcirculation.

Background Found in Inflammatory Zone 1(FIZZ1)is a newly found protein associated with pulmonary inflammation.We previously had reported its role in the development of atherosclerosis,but its detailed mechanism has not been explored.Objective This study was designed to delineate the effect of FIZZ1 on the expression of scavenger receptor(SR-A)in vascular smooth muscle cells(VSMC)scavenger receptor(SR-A)induced by ox-LDL.Methods Smooth muscle cells were treated with ox-LDL(20 mg/L)or cocultured with recombinate FIZZ1 at different concentration(final concentration 3?10-6,9?10-6,2.7?10-5 mmol/L).The expression of SR-A of smooth muscle cell was detected by flow cytometry and laser confocal microscopy.Results SR-A positive expression was found in VSMCs treated with ox-LDL after 24 hours,which were located mainly in cell membrane by laser confocal microscopy.FIZZ1 significantly accentuate the LDL induced increases in SR-A positive rate in VSMC in a dose dependent manner(P

Objective To explore the in vitro antioxidation effect of Xinmaishen oral liquid(XMSol, a Chinese patent medicine) on low density lipoprotein(LDL). Methods Serum containing XMSol was prepared by serum pharmacological method. The oxidized LDL was obtained by 0.5 mg/ml of LDL in the presence of 10 ?mol/L CuSO 4. XMSol, CuSO 4 and serum containing XMSol and CuSO 4 were added to LDL for incubation. Content of MDA was determined and the antioxidation effect of XMSol was evaluated. Results XMSol could reduce MDA production due to oxidation of LDL in a dose dependent manner. Conclusion XMSol can inhibit the in vitro oxidation of LDL dose dependently.

0 05] Conclusion Ang (1 7) can exert certain protective effect on renal fibrosis in 2K1C hypertensive rats, and can attenuate proteinuria

Objective To investigate the effects of exercise on serum soluble cell adhesion molecules and cytokines of patients with dyslipidemia. Methods Eighty patients with dyslipidemia were randomly and equally divided into an exercise group and a control group. The control group was treated with pravastatin,while exercise was administered in the exercise group in addition to the pravastatin. Both groups were observed for 8 weeks. Results Serum leves of soluble endothelial leucocyte adhesion molecule 1(sELAM),soluble intercellular adhesion molecule(sICAM 1)and interleukin 1?(IL 1?)of patients in both groups were decreased significantly. Moreover,serum levels of soluble vascular cell molecule 1(sVCAM 1)and tumor necrosis factor ?(TNF ?)in addition to sELAM,sICAM 1 and IL 1? were decreased significantly in the exercise group,with a significantly better result in the exercise group as compared with that of the control group. Correlation analysis revealed a positive correlation of individual sELAM,sICAM 1 and sVCAM 1 with blood total cholesterol(TC),and negative correlation of individual sELAM,sICAM 1 and sVCAM with high density lipoprotein cholesterol(HDL C)in exercise group. Conclusion Adequate exercise has beneficial effects on patients with dyslipidemia by reducing serum levels of soluble adhesion molecules and the production of proinflammatory cytokines,which was realized possibly through modulating serum lipids and improving endothelial dysfunction.

Using Low Shear-30 rheometer, we studied apparent viscosities at high (51.2-128.5s~(-1)), moderate (11.02-37.6s~(-1)), and Low (0.376-8.11s~(-1)) shear rate, viscoelastic properties of whole blood and hemodynamic parameters in 10 patients with acute myocardiac infarction(AMI), comparing with 10 patients with angina pectoris (AP) and 11 normal subjects(NS). It was demostrated that the apparent viscosities of whole blood at different shear rates mentionned above and viscoelastic properties of whole blood (the dynamic modulus G′, the loss modulus G″, "the viscous ?′ and the elastic component ?″ of complex viscosity) increased distinctly and parameters of cardiac function (EF, CO, LVET, PEP/LVET, HI, SV and CI) were abnormal obviously in AMI, in comparing with AP and NS (P

Relationship between hemorheology and blood gas analysis was studied in 37aged patients with chronic cor pulmonale, including 17 instable and 20 stable. Apparentviscosity (?a) of shear rate of 230.4 (?a(H)) and 5.76/s (?a(L)), TK values, redcell aggregation index(RAI) and PaCO_2 in instable chronic cor pulmonale (AG) were muchhigher than that of stable. patients (BG). Oxygen delivery index (OD) and PaO_2 in AGwere lower than in BG. ?a (H) was negatively correlated with OD and pH (r=-0.58,-0.40, P

Background FIZZ1 is a newly found protein associated with pulmonary inflammation. It has been shown to involve in proliferation of pulmonary arterial vascular smooth cells, contriction of vascular vessels, and stimulation of fibroblasts. Objective This study was designed to investigate the expression of FIZZ1 in atherosclerotic plaque of C57BL/6J ApoE-/-mice and the role of FIZZ1 on the proliferation of vascular smooth muscle cells obtained from aorta. Methods Nine C57BL/6J ApoE-/-mice were fed with high fat diet and nine C57BL/6J wild type mice with normal chow for 24 weeks. All mice were euthanized and the aortas were collected. HE stain histological examination and FIZZ1 immunohistochemistry were used in vivo study. In vitro, smooth muscle cells were treated with normal saline (control groups) or recombinate FIZZ1 at different concentrations (final concentration 3?10-6, 9?10-6, 2.7?10-5 mmol/L) respectively. The proliferation of smooth muscle cells were detected by MTT. Results After 24 weeks of high fat diet treatment, large atherosclerotic plaques were found in aortic root of ApoE-/-mice. FIZZ1 was found in atherosclerotic plaques of C57BL/6J ApoE-/-mice, however, no FIZZ1 was expressed in the arteries of C57BL/6J wild type mice. Cell culture study showed FIZZ1 promoted the proliferation of smooth muscle cells in a dose dependent manner(P

Fifty-two patients with silient myocardial ishcemia (SMI) were categorized into Type Ⅰ SMI group (n=21) and Type HI SMI group (n=31).22 normal subjects were also observed to serve as the control.It was found that the apparent viscosity of whole blood at different shear rate of 192.0 s-1,30.72s-1,and 3.84 s-1,the plasma viscosity,and the inter-viscosity of erythrocytes,and the duration of total myocardial ischemia on Holter monitoring electrocardiogram were higher and longer in Type Ⅲ SMI patients than in Type Ⅰ SMI ones and the normal controls (P

ObjectiveTo investigate the correlations between Herpes simplex virus (HSV) infection and acute myocardial infarction(AMI).MethodsSpecific antibodies and DNA to HSV-1 were measured in 51 patients with AMI(AMI group),42 patients with old myocardial infarction (OMI group) and 31 normal controls (NC group) who had no angiographic evidence of coronary artery disease.Moreover,the changes of and relationships between fibrinogen(Fg),6-Keto-prostaglandin-F 1? (6-Keto-PGF 1? ),Thromboxane B 2 (TXB 2 ),P-selection(GMP 140 ) and HSV-1 infection were determined in the three groups.ResultsThe prevalence of HSV-1IgG antibody was associated with AMI(OR4.266).Adjustment for the major cardiovascular risk factors didn't attenuate this correlation(OR3.321).Those who were HSV-1 positive in the AMI group had significantly higher levels of Fg,TXB 2 and GMP 140 and a significantly lower level of 6-Keto-PGF 1? than those who were HSV-1 negative in the same group.Correlation analysis revealed that the average concentration of IgG antibody to HSV-1 was positively associated with the levels of Fg,TXB 2 and GMP 140 but negatively associated with the level of 6-Keto-PGF 1? in the HSV-1 positive patients of the AMI group.ConclusionThere is a significant correlation between HSV-1 infection and AMI.HSV-1 infection is associated with Fg,TXB 2 ,6-Keto-PGF 1? and GMP 140 .