Objective To observe the effect of bronchial asthma in rats treated by Chuanzhuping,a prescription which has the function of dispersing lung Qi and invigorating spleen Qi,and explore its possible mechanism.Method Thirty-two male Wistar rats of SPF level were divided into four groups randomly:control group(A),asthma group(B),Dexamethasone group(C) and Xiaozhuping group(D).Except group A,the others were established animal model of asthma.After drawing materials,hematoxylin and eosin(HE) staining were performed.The pathological changes in bronchopulmonary tissue of rats were detected.The basementmembrane perimeter(Pbm),the airwaywall area(Wat) and the smooth musclewall area(Wam) were measured and calculated by using image analysis system.The concentration of transforming growth factor-?1(TGF-?1) in bronchopulmonary tissue was observed by immunohistochemical method and the integral optical density(IOD values) of it was measured.Results In bronchopulmonary tissue of group B,Wat,Wam and the concentration of TGF-?1 increased,and were significantly different from that in group A(P0.05).In group D,the concentration of TGF-?1 decreased and was significantly different from that in group C(P

Diabetes is a common clinical disease, with glucose and lipid metabolism disorder as the main clinical manifestation. The spleen of middle jiao can transport and transform the essence of grain and water. It is also the source of qi and blood, which also provides material foundation for the glucose and lipid metabolism. The spleen deficiency and dampness stasis can lead to the phlegm and blood stagnation, which are closely related to high sugar, high fat, high blood coagulation and vascular endothelial damage. This article discussed the relationship between the changes of spleen function of middle jiao and glucose and lipid metabolism, and provided some theoretical methods for clinical prevention and treatment of diabetes.

Objective To investigate the risk factors of postoperative pancreatitis after endoscopic retrograde cholangiopancreatography(ERCP),establish a quantitative risk prediction model,and conduct external validation.Methods The clinical data of patients with ERCP were analyzed.Among them,603 ERCP patients From January 2017 to January 2021 were selected as the modeling group,and 205 ERCP patients from March 2021 to March 2022 were selected as the validation group.Pancreatitis was diagnosed according to Atlanta standards.There were 45 cases in the modeling group and 23 cases in the validation group developed pancreatitis after ERCP.Compare the clinical data and biochemical indicators of patients with and without pancreatitis in the modeling group,and screen for risk factors of pancreatitis through multivariate Logistic regression analysis.Then,establish a risk prediction model and validate it.Results Univariate analysis showed that there were statistically significant differences in age,history of gastectomy,calculus of common bile duct,papillary foramen nodule type,pancreatic wire channel,sphincterotomy,serum total bilirubin and albumin between the two groups(P＜0.05).Multivariate Logistic regression analysis showed that the history of gastrectomy(O(R) = 6.417,95%CI:1.900～21.675,P = 0.000),calculus of common bile duct(O(R) = 3.442,95%CI:1.496～7.917,P = 0.000),papillary foramen nodule type(O(R) = 2.447,95%CI:1.072～5.585,P = 0.018),pancreatic wire channel(O(R) = 3.673,95%CI:1.609～8.383,P = 0.000),sphincterotomy(O(R) = 1.758,95%CI:1.140～2.711,P = 0.004),elevated total bilirubin(O(R) = 1.415,95%CI:1.084～1.847,P = 0.008)and decreased albumin(O(R) = 1.239,95%CI:1.016～1.510,P = 0.010)were independent risk factors for post ERCP pancreatitis.Establish a risk prediction model Y =-1.023 + 1.859×(history of gastrectomy)+ 1.236×(calculus of common bile duct)+ 0.895×(papillary foramen nodule type)+ 1.301×(pancreatic wire channel)+ 0.564×(sphincterotomy)+ 0.347×(elevated total bilirubin)+ 0.214×(decreased albumin).The receiver operator characteristic curve(ROC curve)showed that the area under the curve(AUC)of the model predicting pancreatitis in the modeling and validation groups were 0.895 and 0.864,respectively.After assigning values to each variable in the model,it was divided into low risk(0～5 points),medium risk(5～10 points),and high risk(≥10 points).The actual incidence of high-risk pancreatitis in the modeling and validation groups was significantly higher than that of low-risk patients,and the actual incidence of high-risk pancreatitis was significantly higher than that of medium risk patients,with statistical significance(P＜0.05).Conclusion The history of gastrectomy,calculus of common bile duct,papillary foramen nodule type,pancreatic wire channel,sphincterotomy,elevated total bilirubin and decreased albumin were independent risk factors for post ERCP pancreatitis.We have developed a quantitative risk prediction model with good predictive efficacy for pancreatitis,which has important clinical application value.