OBJECTIVE:To establish a method for the determination of serum indapamide concentration.METHOD:10healthy male volunteers were assigned to receive7.5mg indapamide capsule on empty stomach with time-concentration de?termined by HPLC,and the pharmacokinetics parameters were accounted.RESULTS:C max was(0.212?0.167)mg/L,t max was(2.14?0.59)h,t 1/2 was(19.69?0.75)h,AUC 0～72 was(3.636?0.503)(mg?L)/h and AUC 0～∝ was(3.937?0.518)(mg?L)/h.CONCLUSION:The established method can be used for the clinical analysis on the use of indapamide and its pharmacokinetics study.

Objective Analysis Chinese Journal Of Behavioral Medicine And Brain Science articles (CJBMBS) in 2009 year. Methods All the articles in CJBMBS which were published periodically on 12 issues in 2009 distribute were taken as the object, papers such as the Notices,Posters and Conferences were not included.Analysis the number of articles published, the article columns, the articles published style and the quotation quantity and so on. Results The CJBMBS in 2009 year altogether published 445 pieces papers, 12 issues, 1152 pages. Each issue carries articles 37.08 pieces equally and each article averages 2.59 pages. The density of each article is 0.3863,the information density is 6.181. The foundation investigative manuscripts account for 18.20%;the clinical investigative manuscripts account for 34.38%; the sanitary precaution manuscripts accounts for 28.09% ;the psychological behavior appraisal class manuscripts account for 6.07%;the monograph class manuscript accounts for 4.72; Summarizes 8.09%. The quotation quantity are 5252,each article' s quotation averages 11.80;The quotation quantity differs greatly, review articles' are the highest to be 34.67, while the short articles' are the lowest to be 10.43. The Pryse index mean value is 58.13%. The review articles' cited frequency is lowest to be 22.52% ,and that of short article report is highest to be 68.78%;the average self cited frequency is 17.86%.Conclusions CJBMBS in 2009 has plentiful information resources;among the total published articles papers are the chief.The quotation quantity per article is higher than average quotation quantity in scientific article in China. The Pryse index is higher than the mean value of various scientific and technology disciplines. Self cited frequency is moderate.

Objective To further investigate the relationship between apolipoprotein E(APOE) genotype and trait anxiety in patients with coronary heart disease (CHD).Methods Use the state-trait anxiety inventory (STAI) to investigate the state anxiety and trait anxiety of 107 CHD patients.According the score of TAI,the CHD patients were divided into CHD with high trait anxiety group ( n=39)and low trait anxiety group(n=68).The genotypes and alleles of apolipoprotein E gene was detected in all CHD patients and 50 healthy control subjects with the polymerase reaction(PCR) and restriction fragment length polymorphisms(RFLP) technique.Correlation analysis and logistic regression analysis were used.Results Apolipoprotein E gene showed positive relationship with trait anxiety score( OR =9.251,95％ CI2.726 ～ 18.266).F4 allele entered the regression equaltion Y =30.252 + 0.048X3 (P ＜ 0.05 ).Conclusion The results suggest the polymorphisms of Apolipoprotein E e4 allele may be associated with the trait anxiety symptom.

Objective To analyze the articles and authors published in Journal of Chinese Behavioral Medicine and Brain Science(JCBMBS) in 2012.Methods By using the bibliometric statistical methods,all papers published in JCBMBS in the whole year of 2012 were analyzed,including the paper amount,the paper column,the published style of papers,the institute distributions and the area distributions of the first authors,the foundation supported papers amount,the author amount,the citation amount and the published delay.Results 375 papers were published in JCBMBS in 2012,31.25 papers were published in an average issue,and one article included 3.06 pages averagely.The paper density was 0.327 and the information density was 5.21.The main style of published papers was original article,which accounted for 79.7％,and the least style was experts forum articles,which accounted for 2.4％.The amount of clinical research articles were 129,the hygienic articles were 89 and the basic research articles were 80.The area distributions of the first author were wide and imbalance.The top 6 provinces of the most published paper amounts in 2012 were Shandong,Jiangsu,Guangdong,Beijing,Anhui and Henan,where published paper amounts in total were 207 papers,and accounted for 55.2％ of the total papers of the whole year.There were 244 articles supported by various foundations and accounted for 65.06％ of the total papers of the whole year,in which 30.93％ was supported by the national foundations.The average author amount of the published papers,the average citation amount and the average published delay were 4.71 authors,15.58 indexes and 161.5 days respectively.12 corresponding authors had published 3 or more than 3 articles,and 37 corresponding authors had published 2 articles in the year.The top fifteen institutes of the most paper amounts in the periodical had published 145 articles,accounting for 38.7％ of the total amount of the papers.Conclusion The JCBMBS have an aboundant information resource;the main style of the published papers is original article;the clinical researches are the most in all columns.There are higher foundation supported papers and steady authors of this periodical.

Objective To analyze the papers published in Journal of Chinese Behavioral Medicine and Brain Science(JCBMBS) from 2009 to 2014 so as to know well of the characteristics of published papers and the progress of the journal.Methods Based on the published magazines,Wanfang database and the Magtech system,bibliometric analysis was conducted to analyze the quantity,types,authors,cooperation,citations and the funds of all the papers published from 2009 to 2014.Results A total of 2 343 papers were published from 2009 to 2014 with the average 390.50 items per year,32.54 items per tissue and 0.34 items per page.It was stable in columns setting and publishing types while the original papers accounted for more than 70％ every year.Zero fund-supported papers decreased year by year and the funds were 1.41-1.83 per article while the ratio of national funds supported papers were 20％-31％.It had a steady author group and the high produced institutions maintained stable.The ratio of cooperation in institutions were 45％-58％.The ratio cooperation in authors were 95.45％-97.09％ and it was high and steady.The citations were 12.45-18.48 per article which increased year by year.Conclusion From 2009 to 2014,the annual published articles on JCBMBS decrease,the paper density decreases and the citations increase year by year.It is relatively steady in columns setting,core authors,ratio of fund-supported papers and cooperation.

Objective To investigate the effect of the 5-hydroxytryptamine (5-HT) on the occurrence,development of post-stroke depression (PSD).Methods The literatures on the relationship between 5-HT and PSD were selected from databases such as Wanfang Data,CNKI and PubMed before in 2010-2014.According to absorption and exclusion criteria of the literature,collect literatures,and summary,induce and analyze on them.Results Search 258 literatures and accept 44 literatures accorded with the criteria,including the relationship between 5-HT and PSD,the relationship between 5-hydroxytryptamine receptor (5-HTR) gene polymorphism and PSD,the relationship between 5-hydroxytryptamine transporter linked promoter region (5-HTTLPR) and PSD,and the treatment of selective serotonin reuptake inhibitors (SSRIs) in PSD.Conclusion Reduced levels of 5-HT lead to the occurrence of PSD,and they had a negative correlation;5-HTR 1 A,5-HTR2A are related genes of PSD;S allele and S/S genotype is susceptible factors of PSD,while the L allele is the protective factors of PSD;SSRIs can increase the level of 5-HT in the synaptic gap so as to improve the depressive symptoms of PSD.In the future,it is necessary to increase the sample size to confirm the relationship between 5-HT and PSD,and combine with other factors to explore the relationship between them.

Post-stroke aphasia is an acquired language disorder caused by stroke.It impaired the quality of life of patients and brought a heavy burden to family and the society.Unfortunately,the highly variable predictive factors make the prognosis of aphasia recovery difficult.Much of the researches indicated that the post-stroke aphasia recovery is associated with the patient-related and stroke-related factors.We searched the recent advances on the influence of patient-related factors and stroke-related factors on aphasia recovery.It showed that patient-related factors have no obvious effect on predicting aphasia recovery while the lesion (stroke)-related factors appeared close correlation with post-stroke aphasia recovery.The clinicians should pay more attention on lesion (stroke)-related factors when evaluate the outcome and give the intervention measures.

To analyze the mortality risk of stroke in China by literature search.The mortality rate of stroke (age standardized) in China has declined in recent years.The mortality rate of stroke which increases with age is higher in rural areas than in urban areas,and is higher in men than in women in China.There are obvious regional differences and seasonal differences in the mortality of stroke in China.Different subtypes of stroke have different death characteristics.Low or high temperatures can increase the risk of mortality of stroke.With the change of epidemiological characteristics,the risk factors of mortality of stroke in China are also changing.Through the epidemiological study of stroke death,the mortality risk of stroke can be researched effectively,the epidemiological characteristics of stroke can be mastered,and the direction of prevention and treatment of stroke can be understood.Individualized and multi factor intervention for unhealthy lifestyle,unhealthy behavior and metabolic cardiovascular risk factors can promote the establishment of stroke prevention and control strategy in China.

Objective To study the relationship between sensation seeking,personality characteristics and health-risk behaviors of medical freshmen.Methods Sensation Seeking Scale ( SSS),Eysenck Personality Questionnaire( EPQ),Adolescent Health-Risk Behaviors Questionnaire were applied in this survey to 384 freshmen from two medical colleges.Results ① The health risk behaviors were comnmon in the medical college freshmen (5.2％,48.2％ ),and the score of health risk behaviors had a significant difference between boys and girls,boys risk behaviors were much more than girls(P＜ 0.05 ).②The correlations between the risk behaviors (such as smoking,drinking,fighting,suicidal ideas,using internet too long,poor eating behavior,lack of physical exercise) and sensation seeking personality traits were strong.The health-risk behaviors were all correlated with extraversion(E)and neuroticism (N) significantly( 66.78 ± 10.29 vs 60.57 ± 9.09,t =2.54,P ＜ 0.01 ;7.11 ± 3.23 vs 5.33 ±2.89,t =2.81,P ＜ 0.05 ).③The results of logistic regression analysis showed that male mother' s high education level,sensation seeking,Eysenck' s P,N dimension were effective prediction factors of freshmen ' s health-risk behaviors.Conclusion Medical college freshmen who have higher levels of sensation seeking,Eysenck' s P,N dimension are more prone to health risk behaviors.

Objective: To analyze the trend of citation index of Chinese Journal of Behavioral Medicine and Brain Sciences(CJBMBS) from 2011 to 2018, and compare to the average level of Chinese Medical Association(CMA) series journals, so as to provide basis for improving academic quality and journal influence. Methods: Trend analysis on citation index of CJBMBS from 2011 to 2018 and comparison with the average level of Chinese Medical Association series journals were conducted by Microsoft Excel 2010. Results: From 2011 to 2018, the core impact factor(0.849-1.151) and ratio of foundation-supported papers(0.550-0.810) of CJBMBS showed an upward trend, while the core total citation(1 783-2 836) showed a downward trend.The core total citation, core impact factor and ratio of foundation-supported papers of CJBMBS were higher than the average level of CMA series journals(1 355-1 699, 0.497-0.890, 0.335-0.460), but the core other-citation rate was lower than the average level of CMA series journals (0.81-0.85). Conclusion The CJBMBS is at a high level among the core journals of Chinese science and technology, and more attention should be paid to the problem of high self-citation rate.