Objective To investigate the effect of transcranial magnetoelectric stimulation (TMES) on temporal lobe epilepsy induced by kainic acid (KA) in rats.Methods Sixty-two rats were randomly divided into pretreatment group (n=32) and treatment group (n=30);rats in the pretreatment group were divided into 4 subgroups,giving TMES at 0％,25％,50％,and 75％ maximum current intensity (MCI),respectively,to conform the optimal TMES current.Rats in the treatment group were divided 3 subgroups (n=10):TMES epilepsy group (giving TMES at optimal current),non-TMES epilepsy group,and control group;TMES was given 40 min/once daily for 14 d;the behavior,histological and electrophysiological changes of rats in the 3 groups were recorded,and the treatment efficacy of TMES in epileptic rats were evaluated.Results The optimal current was 50％ MCI.The frequency of epileptic waves in TMES epilepsy group was significantly lower than that in non-TMES epilepsy group ([30.210± 4.580] times/min vs.[31.380±4.247] times/min,t=3.325,P=0.001).Timm staining results indicated significant differences among the three groups (F=17.429,P=0.000),and the degree of Timm staining in the inner molecular layer of hippocampus dentate gyrus in the TMES epilepsy group was significantly slighter than that in the non-TMES epilepsy group (P＜0.05).Conclusion TMES can influence the formation of dentate gyrus neurons loop by improving molecular layer histological changes in epileptic rats,thereby reducing frequency of epileptic EEG seizures.