OBJECTIVE: To find out the critical influential factors of measurement in the determination of Roxithromycin dispersible tablets. METHODS: Mathematic model of HPLC was established to analyze the effects of many uncertain factors on measurement results. Combined standard uncertainty and expanded standard uncertainty were calculated. RESULTS: The expanded uncertainty was 1.6% and the results of determination could be expressed as (96.8?1.6)%. CONCLUSION: The established analytical method is applicable to the uncertainty analysis in the content determination of Roxithromycin dispersible tablets by HPLC.

Objective To carry on the training of empathy ability among nursing undergraduates and understand its influence on that empathy and professional commitment. Methods Nursing undergraduates of two classes in the Chengdu University of TCM were selected as the objects in this study, who had accepted Nursing Psychology. The students in one class (52 cases) as the intervention group, while the students in the other class (61 cases )as the control group. Routine education was used in the control group, the empathy education was used in the intervention group in addition. On the basis of the Jefferson Scale of Empathy (JSE) and Nursing professional commitment Scale a survey on empathy ability among nursing undergraduates and professional commitment had done for the investigation of its influence on those two sides. Results After the training, the general professional commitment scores in the intervention group was 85.89 ± 11.86, which was significant higher than 77.53 ± 11.93 in the control group (t=3.822,P < 0.01). The final scores of commitment and empathy had significant relation with their respective latitudes (P < 0.05 or <0.01). Conclusions The training of empathy ability among nursing undergraduates affects their empathy ability and professional commitment. And students’professional commitment can be improved through some targeted trainings.

ObjectiveTo describe the use of endoscopic technique for exposure of the mandibular ramus-condyle unit(RCU) to facilitate reduction and rigid fixation of the fractures.MethodsSixteen patients ( 18 sides) with diagnosis of subcondylar fracture ( 11 sides),condylar neck fracture ( 2 sides ),and mandibular ramus fracture (5 sides ),who underwent endoscopic exposure of the RCU and fixation with miniplates by an extraoral or transoral approach.Six sides were no displacement,10 sides were obvious displacement,and 2 sides were dislocation.ResultsAll patients had successful treatment of fractures of the mandibular RCU,all patients showed quick recovery to preinjury occlusion.Followed up 12-36 months,normal temporomandibular joint function was noted in all patients.No patient had marginal mandibular nerve weakness or other complications.ConclusionsIt demonstrates the feasibility of endoscopic access to the RCU for treatment of the fractures.The procedures can be performed with minimal morbidity and functional impairment.

Objective To conduct a retrospective analysis of the relationship between the time of rehabilitation intervention and its effectiveness among hemiplegic patients after cerebral infarction.Methods Fifty-four hemiplegic stroke patients within 1 week of onset were randomly divided into three equal groups of 18:In the A group rehabilitation was begun 1 to 2 weeks after onset; in the B group it was started between 2 and 4 weeks; in the C group rehabilitation was begun after four weeks.The patients all received comprehensive hemiplegic limb training,electric standing bed training,functional electrical stimulation and medical gymnastics for hemiplegia.Motor function was assessed using the Fugl-Meyer balance function assessment and the modified Barthel index before treatment,in the course of the first week of treatment and 3 months later.Results A group and B group made similar progress,but the curative effect in group C was significantly weaker.Conclusion Rehabilitation should be started within 1 month after the onset of cerebral infarction.

Objective To study the quality of life(QOL) and its associated factors in patients with traumatic brain injury (TBI) . Methods The 148 TBI patients treated and discharged from department of neurosurgery Chongqing beibei district people′s hospital were selected out and involved in the investigation .the World Health Organization health-related QOL BREF (WHOQOL-BREF) was used to investigate the QOL .116 valid questionnaires were obtained .Results The scores of physiological ,psychological ,social relationship ,environment domains of QOL among the patients with TBI were (69 .37 ± 17 .46) ,(59 .16 ± 14 .47) ,(54 .17 ± 14 .64) , (49 .33 ± 18 .33)scores .Multiple stepwise regression analysis results showed that ,age ,place of residence ,brain injury parting were risk factors for brain injury patient's quality of life ,GOS scores ,degree ,discharge time interval were protect factors (P< 0 .05) . Conclusion The QOL of the patient with TBI discharged from the hospital was lower than the domestic general population .The patient′s age ,residence ,educational level ,the type of TBI ,GOS score ,the time to discharges were the main influencing factors .

Objective:To investigate the expression and clinical significance of glycosylated albumin(GA) and glycosylated hemoglobin(HbA1c) in patients with diabetic microangiopathy(MVCD).Methods:A total of 295 patients with type 2 diabetes admitted to Chaoyang Central Hospital of Liaoning Province from May 2017 to July 2019 were selected as case group, and they were divided into simple diabetes group (217) and microvascular disease group (78) according to whether the patients had microvascular lesions.Two hundred healthy people were selected as normal control group.The levels of GA and HbA1c were compared between the case group and the normal control group, and the levels of GA and HbA1c in the diabetic group and the microvascular disease group were compared.The risk factors of microangiopathy in patients with type 2 diabetes mellitus were analyzed by logistic regression analysis.Results:The levels of GA and HbA1c were (23.9±10.1)% and (8.6±2.3)% in the case group, which were (13.4±1.2)% and (5.0±0.6)% in the normal control group.The differences between the two groups were statistically significant( t=14.628, 21.636, all P<0.01). The levels of GA and HbA1c were (22.8±9.7)% and (8.4±2.0)% in the simple diabetes group and (25.4±10.3)% and (9.2±2.4)% in the microvascular disease group.The differences between the two groups were statistically significant( t=1.997, 2.869, P=0.047, 0.004). Logistic regression analysis showed that GA and HbAlc were risk factors for microangiopathy in patients with type 2 diabetes ( OR (95% CI) values were 1.088 (1.030-1.157) and 15.251 (1.756-131.157), P=0.003 and 0.014). Conclusion:The occurrence of MVCD is related to GA and HbA1c.Logistic regression analysis showed that GA and HbA1c levels were risk factors of MVCD, and could be used as predictive factors of MVCD.

Right ventricular failure(RVF)is a severe clinical syndrome that affects human health seriously.The establishment and application of experimental animal models are critical to research the pathogenesis, pathophysiology, prevention and treatment of RVF.Recently, numerous researchers have studied the modeling methods and testing indexes of RVF of animal models, which has improved the success rate and quality of the models.However, even if so many models, there is still no widely accepted experimental animal model of RVF because of the different and complex modeling methods, material selection and experimental conditions.This article reviews the methods and mechanism of multiple experimental animal models of RVF and compares them, so as to provide reference for choosing and applying experimental animal models of RVF in the study.

Adenosine is an important signaling molecule of the central nervous system (CNS). Adenosine typically released in the phosphorylated form(ATP), together with neurotransmitter, both of which are encapsulated in the synaptic vesicles. Once released into the synaptic space, adenosine molecules will bind to their three categories of receptors, namely A1 receptor (A1R), A2 receptor (A2R), A3 receptor (A3R), and therefore start G protein mediated signaling pathways, resulting in various and extensive biological effects. It has been discovered in recent years that adenosine has a certain level of anti-depression effect, although its mechanisms are yet to be elucidated. This review summarized the researches focusing on anti-depression roles of both adenosine and its receptors.

Abstract?AlM:To analyze the blindness causes of 1854 cases in our hospital hospitalized patients, and explore the strategy and direction of blindness prevention according to the different treatment efficacy.?METHODS: Cluster sampling was used to select from September 2010 to August 2013 in our hospital department of ophthalmology patients 5 473 cases, in which total of 1 854 cases of blind patients, accounting for 33. 88% of hospitalized patients. According to the WHO's criteria of blindness. The BCVA enacted <0. 05 or vision radius less than 10 degrees are for the blind, and the exclusion of less than 3 years old children don't cope with visual inspection of the inclusion criteria for age and cause of blindness blind patients were analyzed. To the blind to patient age and etiology were analyzed, the main cause of blindness and statistics of all ages, records of the blind patients after treatment eye sight;and calculating the blindness of the literacy rate, on the blindness through analysis of the causes of the risk treatment.?RESULTS:ln 1 854 cases of blind patients, including 728 people right-eye blinding, 767 people left-eyes blinding, 359 people total blinding, adding up to 2 213 eyes, aged from 60~80 years old were in the majority. The top three diseases resulting blindness were cataract, diabetic retinopathy and glaucoma. ln 2 213 blind eyes, the eyes treated were 2 172, of which 1 762 eyes ( 81. 12%) were succeeded, 410 eyes ( 18. 88%) failed. ln the failed cases, the first three diseases were diabetic retinopathy, glaucoma and retinal detachment.?CONCLUSlON: ln recent years, disease etiology of blinding eye has changed, but cataracts, diabetic retinopathy and glaucoma are still high incidence of blindness due, so the treatment of diabetic retinopathy, glaucoma and retinal detachment should be the emphasis for blindness prevention and treatment in the future.

Objective To investigate the abnormality of fluid distribution and its effect on blood pressure (BP) in hemodialysis patients. Methods One hundred and six healthy volunteers as normal controls were divided into two groups(male group and female group).ECV%?ICV%(% means a percentage of weight) and ECV/ICV were measured by bioelectrical impedance spectroscopy and calculated in 2 groups respectively.Sixty-seven stable HD patients who had been on HD for more than 2 months in our hospital were selected. Patients were divided into 4 groups (hypotension prone group, normotensive group, hypertensive group and refractory hypertensive group). ECV%, ICV% and ECV/ICV were measured and calculated as above immediately before and after HD session. The measurement was conducted by Xitron 4200 HYDRA ECF/ICF Bio-Impedance Spectrum Analyzer. Results In patients on HD, a significant decrease of ECV% and ECV/ICV, and a significant increase of ICV% were seen post-HD. The pre-HD ECV% and ECV/ICV were significantly higher than those of normal controls but dropped close to normal level after hemodialysis. Post-HD ECV% was still higher than that of normal controls[(31.6?1.0)% vs (25.3?1.6)%, P 0.05]and post-HD ECV% of these patients was significantly lower than that of normal controlsand post-HD ECV% of these patients was significantly lower than that of normal controls[(19.3?1.6)% vs (22.6?1.4)%,P