Objective:To investigate the effect of early intervention on intelligent development of the premature infants. Method:62 premature infants were randomly assigned to the intervention group and the control group. The early intervention began from the birth of the infants to their 2 years old.Result:At the age of one and two, the mental development index (MDI) and psychomotor development index (PDI) were significantly higher in the intervention group than in the control.Conclusion:Early intervention can improve intelligent development of premature infants.