OBJECTIVE To identify the risk factors,distribution and kinds of pathogens and control measures for the patients with autoimmune disease(AD) complicated with fungal infections.METHODS Statistical analysis was carried out on the clinical data of 38 patients with AD complicated with fungal infaction.RESULTS The fungal infection in AD mainly occurred in the respiratory tract,urinary tract,digestive tract and on the skin.The main factors of these patients more likely were disturbed immunity,and unreasonable usage of corticosteroids,immunosuppressive agents and antibiotics.CONCLUSIONS It should as early as possible onset the clinical antifungal therapy,reasonable using of corticosteroids,immunosuppressive agents and antibiotics for fungal infaction,and supportive treatment according to the result of antifungal susceptibility test.