BACKGROUND:Animal experimental studies have confirmed that cell transplantation,neurotrophic factor infusion or transplantation as well as other methods can alter the local environment of injured spinal cord and promote its partial function recovery. OBJECTIVE:This study aimed to assess the clinical efficacy of olfactory ensheathing cell transplantation for the treatment of the sequel of myelitis,and to explore whether it would promote the recovery of the spinal cord function. DESIGN:A non-randomized self-control study. SETTING:Ward of Second Department of Surgery of Taian Disabled Soldiers Hospital of Shandong Province. PARTICIPANTS:Thirty-two patients with obsolete myelitis,who come from all over China and suffered from disease for 0.5 to 7 years,admitted to our hospital between June 2004 and July 2007 were recruited in this study.The involved patients,including 21 males and 11 females,were aged 5-48 years.Their neurological functions were not obviously improved after various conventional treatments and limb function exercise.Meanwhile,various sensorimotors and autonomic nerve functional impairments were left.Among the patients,18 suffered from acute viral myelitis,8 from acute purulent myelitis and 6 from tuberculous myelitis.After onset,they were all given large doses of radiosonde, dexamethasone,anti-inflammatory and immunomodulatory drugs and various neurotrophic drugs.Twenty-six patients presented complete injury and six patients incomplete injury.Informed consent of treatment was obtained from each patient.The therapeutic protocol was approved by the Ethics Committee of the hospital.Embryonic olfactory bulbs were harvested from aborted embryo,which was donated voluntarily by the patients or their relatives. METHODS:Cells were isolated from embryonic olfactory bulbs,cultured and purified for 7 to 14 days,and finally they were digested into single-cell suspension.Under the surgical miscroscope,the cells were transplanted onto the regions which were above or below the spinal cord injury site.Two weeks to 2 months postoperatively,neurological function of spinal cord was assessed by using the American Spinal Injury Association(ASIA)Scoring Standard formulated in 2000,and was compared to pre-operation function. MAIN OUTCOME MEASURES:①Sensory function change.②Motor function change. RESULTS:Half a year to 2 years after olfactory ensheathing cell transplantation,the sensory and motor functions of 32 patients were all obviously improved(motor function:55.72?10.50 vs.51.53?13.41;light touch:69.53?11.68 vs. 63.06?15.98;pain sense:69.50?12.20 vs.64.03?15.0,all P

Objective To reveal the biomechanical mechanism of suspension exercise therapy (SET) for treating cervical spondylosis.Methods From August 2015 to December 2016,72 patients with cervical spondylosis were divided into experimental group (SET treatment group) and control group (traction treatment group) based on simple random sampling methods.For experimental group:9 males and 27 females,the average age (45.19 ±10.09) years old,the average disease course (24.94 ± 18.07) months.For control group:11 males and 25 females,the average age (44.08 ± 8.88) years old,the average disease course (22.17 ± 14.96) months.The mechanical properties of neck muscles before treatment and at the end of disease course were tested by Biodex Ⅲ Isokinetic Testing System.Results Before treatment,there were no signficant differences in the peak torque (PT),average power (AP),peak torque of flexor/extensor peak torque ratio (F/E) for both groups;after treatment,PT,AP,F/E in experimental group was improved compared with those in control group (P ＜ 0.05).Significant differences in PT,AP,F/E were found for experimental group before and after SET treatment (P ＜ 0.05).There were no significant differences in visual analogue scale (VAS) of neck pain for both groups before treatment (P ＞ 0.05),while the VAS of experimental group was better than that of control group (P ＜0.05).Significant differences in the VAS were found for experimental group before and after SET treatment (P ＜0.05).Conclusions SET can improve the contraction forces and work efficiency of neck muscles for patients with cervical spondylosis,as well as the coordination ability of flexors and extensors muscles,which will contribute to restoring biomechanical properties of the patients with cervical spodylosis.

Objective:To observe the effect of pelvic band fixation with three-dimensional adjustment of suspended pelvis on patients with pubic symphysis diastasis under the holistic pelvic ring concept. Methods:From February, 2018 to February, 2020, 30 parturients with pubic symphysis diastasis were evaluated pelvic ring. They accepted three-dimensional adjustment of pelvis with suspension to restore the anatomical reduction of sacroiliac joint and the symphysis pubis according to the evaluation, and were fixed with pelvic band for six to eight weeks. The pubic symphysis union was monitored with color ultrasonography. They were reviewed with pelvic X-ray two weeks after removal of pelvic band, and assessed with Visual Analogue Scale (VAS) for pain and modified Barthel Index (MBI) before treatment, immediately after removal of the pelvic band and two weeks after removal of the pelvic band, while the pelvic ring structure was measured. Results:The scores of VAS and MBI improved two weeks after pelvic band removal compared with those before treatment, as well as distance of pubic symphysis separation, upper margin difference of pubic symphysis, width difference of iliac wings, transverse and longitudinal diameter difference of obturator foramens (t > 2.509, P < 0.05). However, the scores of VAS and MBI improved two weeks after pelvic band removal compared with those immediately after removal of the pelvic band (|t| > 2.854, P < 0.05), while the distance of pubic symphysis separation increased (t = 2.319, P < 0.05), still in the normal reference value. Conclusion:Correcting the post-partum pubic symphysis diastasis under the holistic pelvic ring concept can restore the anatomical structure of the pelvis, avoid the compensatory movement pattern, and improve the daily living in the later time.

Objective To reveal the biomechanical mechanism of suspension exercise therapy (SET) for treating cervical spondylosis. Methods From August 2015 to December 2016, 72 patients with cervical spondylosis were divided into experimental group (SET treatment group) and control group (traction treatment group) based on simple random sampling methods. For experimental group: 9 males and 27 females, the average age (45.19±10.09) years old, the average disease course (24.94±18.07) months. For control group: 11 males and 25 females, the average age (44.08±8.88) years old, the average disease course (22.17±14.96) months. The mechanical properties of neck muscles before treatment and at the end of disease course were tested by Biodex Ⅲ Isokinetic Testing System. Results Before treatment, there were no significant differences in the peak torque (PT), average power (AP), peak torque of flexor/extensor peak torque ratio (F/E) for both groups; after treatment, PT, AP, F/E in experimental group was improved compared with those in control group (P<0.05). Significant differences in PT, AP, F/E were found for experimental group before and after SET treatment(P<0.05). There were no significant differences in visual analogue scale (VAS) of neck pain for both groups before treatment (P＞0.05)，while the VAS of experimental group was better than that of control group(P<0.05). Significant differences in the VAS were found for experimental group before and after SET treatment(P<0.05). Conclusion sSET can improve the contraction forces and work efficiency of neck muscles for patients with cervical spondylosis, as well as the coordination ability of flexors and extensors muscles, which will contribute to restoring biomechanical properties of the patients with cervical spodylosis.

Traumatic brain injury (TBI) would result in structural injury and/or physiological disruption of brain. Mild traumatic brain injury (mTBI) can result in vestibular dysfunctions, such as dizziness, vertigo and imbalance. Vestibular rehabilitation is effective on vestibular dysfunction after mTBI. This paper reviewed the possible mechanisms of vestibular dysfunction caused by mTBI, the common assessments of vestibular function and the new progress in vestibular rehabilitation.