Objective:To determine the incident tendency and constituent ratio of thyroid tumors, patient age, and histology, as well as present scientific data for the prevention and treatment of thyroid tumors in Nanchong. Methods:Data were collected in the Affili-ated Hospital of North Sichuan Medical College from 2001 to 2015. Microsoft Excel and SPSS 17.0 were used to analyze the data statis-tically. Results:A total of 3299 cases of thyroid tumors were observed for a span of 15 years. The cases of benign tumors were 2503, while those of malignant tumors were 796. Most cases of benign (33.0%) and malignant (27.3%) tumors occurred in the 40-49 age group. At 35 years old and below, the proportion of patients with thyroid malignant tumors was 23.5%. The number of male patients was 566, while that of female patients was 2733, resulting in a male-to-female ratio of 1:4.8. Conclusion:As the incidence of thyroid tumors increase every year, so does the constituent ratios of thyroid malignant tumors. The onset of tumors in men and women were significantly different. These findings should attract more clinicians' and preventive researchers' attention. Targeted detection, preven-tion, and control need to be carried out immediately.

Objective To examine the tegmental structure of Schistosoma nanjingi using scanning electron microscopy. Methods Adult schistosomes were obtained from infected rabbits with cercariae shedding from Oncomelania snails, which were infected with miracidia of Schistosoma nanjingi. The adult schistosomes were fixed with 4% glutaradehyde, and then, the samples were prepared with the conventional procedures and the schistosomes were examined with a scanning electron microscope (SX-40). Results There were two types of male and female adult worms. For the big male worm, there were big spines and deep cavity on the surface of middle back and some small spines on the surface of middle abdomen; for the small male worm, there were many small spines on the surface of whole back and abdomen. As the big female worm, there were some small spines on the whole tegumental surface. As the small female worm, there were some small spines on the surface of back and abdomen, but the shape of spines was different between the spines of back and abdomen. On the tail surface of the small female worm, there were two types of spines. The spoke-like acetabulum was found. The sensory organelle papillae with or without cilia were found on the tegmental surface of both male and female woems. Conclusion The tegmental structure of Schistosoma nanjingi is much different from that of Schistosoma japonicum.

The traditional experimental teaching of pathology has defect in training the students' operating ability and mobilizing the initiative of students to observe.Pathology Department of North Sichuan Medical College has developed pathology specimens-making competition for undergraduate students.The students observed,chose and made specimens by themselves after sufficient review of the relevant pathology knowledge.The competition has mobilized the enthusiasm of students effectively and developed their operating ability.This form of teaching should become beneficial supplement to the experimental teaching of pathology.

OBJECTIVE: The aim of this study is to investigate the effects of inhibitor HNP1 transfection on proliferation and tumor growth of human nasopharyngeal carcinoma cell line HNE1. METHOD: HNE1 cells were transfected with HNP1 by liposome, and the cytotoxic effect was detected by MTT, In vivo tumor growth test was performed in nude mice inoculated with transfected HNE1 cells. The therapeutic effect of HNP1 was evaluated in the inoculated tumors, alpha-defensin 1 expression was detected in implanted tumor tissues by immunohistochemical stain. RESULT: HNP1 transfection significantly inhibited the proliferation of HNE1 cells. MTT assay confirmed cytotoxic effect. In vivo study showed tumor volume was significantly smaller in HNP1 transfection group than that in control group (P < 0.01). Immunohistochemical stain showed alpha-defensin expression was increased in HNP1 transfection group. CONCLUSION HNP1 transfection can inhibit the proliferation of HNE1 cells, as well as tumor growth.
Animals ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; drug effects ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nasopharyngeal Neoplasms ; genetics ; pathology ; Transfection ; Tumor Burden ; alpha-Defensins ; genetics