Objective To investigate the impact of Coronavirus Disease 2019(COVID-19)on long-term renal function in patients with chronic kidney disease(CKD)who received no renal re-placement therapy.Methods Thirty-nine CKD patients with an estimated glomerular filtration rate(eGFR)＜60 mL/(min·1.73 m2)at the time of COVID-19 diagnosis,admitted to Guizhou Aero-space Hospital from December 2022 to March 2023,were enrolled in the COVID-19 group.Addition-ally,40 CKD patients without COVID-19 from September to December 2021,were included in control group.Changes in eGFR were compared between the two groups,and the temporal trend of eGFR in the COVID-19 group was analyzed using a mixed-effects linear model.Results No statistically sig-nificant differences were observed in eGFR levels at baseline,1-and 3-month of follow-up between the COVID-19 and control groups(P＞0.05).However,at 1 year of follow-up,the eGFR level in the COVID-19 group was significantly lower than that in the control group(P＜0.05).The mixed-effects linear model analysis revealed a decrease in eGFR by 1.84 mL/(min·1.73 m2)within 1 year of COVID-19 onset in the COVID-19 group,which inclined 4.62％from baseline,with the most significant decline(7.45％)observed among diabetic patients.Conclusion Patients with CKD who have not undergone renal replacement therapy experience a substantial decline in eGFR and worsened renal function within 1 year of COVID-19,necessitating close long-term renal function mo-nitoring and timely interventions.

Objective To investigate the impact of Coronavirus Disease 2019(COVID-19)on long-term renal function in patients with chronic kidney disease(CKD)who received no renal re-placement therapy.Methods Thirty-nine CKD patients with an estimated glomerular filtration rate(eGFR)＜60 mL/(min·1.73 m2)at the time of COVID-19 diagnosis,admitted to Guizhou Aero-space Hospital from December 2022 to March 2023,were enrolled in the COVID-19 group.Addition-ally,40 CKD patients without COVID-19 from September to December 2021,were included in control group.Changes in eGFR were compared between the two groups,and the temporal trend of eGFR in the COVID-19 group was analyzed using a mixed-effects linear model.Results No statistically sig-nificant differences were observed in eGFR levels at baseline,1-and 3-month of follow-up between the COVID-19 and control groups(P＞0.05).However,at 1 year of follow-up,the eGFR level in the COVID-19 group was significantly lower than that in the control group(P＜0.05).The mixed-effects linear model analysis revealed a decrease in eGFR by 1.84 mL/(min·1.73 m2)within 1 year of COVID-19 onset in the COVID-19 group,which inclined 4.62％from baseline,with the most significant decline(7.45％)observed among diabetic patients.Conclusion Patients with CKD who have not undergone renal replacement therapy experience a substantial decline in eGFR and worsened renal function within 1 year of COVID-19,necessitating close long-term renal function mo-nitoring and timely interventions.

To evaluate the advantages of using PBL case library in teaching circulatory system diseases to clinical medicine undergraduate students, a PBL case library was established and applied in teaching practice in the reform of circulatory system teaching. The PBL case library achieved the characteristics of combining theories with cases, morphology with functions, and basic knowledge with clinical knowledge. The PBL case library also realized the informatization, query, and update of cases. Preliminary application showed that the median practical score of students in the case library group was 94.00 points, which was significantly higher than the 92.00 points in the control group ( P=0.005). The average lesson preparation time for teachers in the case library group was (5.00±1.00) hours, which was significantly shorter than the (6.89±0.42) hours in the control group ( P<0.001). The difficulty score for lesson preparation among teachers in the case library group was significantly lower than that of the control group [(1.89±1.05) vs. (3.22±0.44), P<0.001]. However, there were no significant difference in theoretical scores and student satisfaction with teachers and courses. These results suggest that the construction of case library can improve practical teaching effectiveness and enhance the efficiency of lesson preparation for teachers.