Small molecule inhibitors of Bcl-2 are a novel class of anticancer drugs that target anti-apoptotic proteins. In recent years,small molecule inhibitors such as ABT-737 ,ABT-263, gossypol, apogossypol,TW-37,obatoclax, HAl4-1 have attracted much reseach attention. Preclinical trials have shown that the inhibitors have cancer killing effect on some tumors when used alone and exhibit striking synergistic effect when combined with radiotherapy and/or chemotherapy.

This paper introduces the principle,basic structure,tansmitting route of excimer laser,and the influence on cornea by performing frequency and power of laser,as well as the development of excimer laser.

Objective To discuss how to improve the management and using efficiency of first-aid equipment.Methods The scientific management of hospital first-aid equipment was discussed in such aspects as administrator,duty,equipment,metrology and personnel.Results The management level and using efficiency of hospital first-aid equipment were greatly improved.Conclusion The method improves the first-aid and synthesis capability.

Autophagy is an evolutionarily conserved lysosomal pathway for the degradation of cytoplasmic proteins,macromolecules,and organelles.Now,autophagic cell death is considered as programmed cell death type Ⅱ.In multiple studies,inhibition of autophagy will result in contrasting outcomes-survival or death.Thus,whether autophagy in cancer cells causes death or protects cells is controversial.Taken together,the manipulation of autophagy may lead to development of new cancer therapies.This article focuses on recent progresses of autophagy research related to human cancers therapy.

Apigenin is a plant flavonoid which has various biological activities and pharmacological effects including anti-tumor, antioxidant, anti-inflammatory, sedative and so on, particularly in the anti-tumor areas. It can inhibit proliferation, invasion, metastasis and angiogenesis of tumor cells. In addition, it can also induce apoptosis and enhance chemotherapy sensitivity.

Objective To provide precise data of encephalic pressure of the patients with higher encephalic pressure.Methods Through a hole bored in the proper position on the top of skull,a 1mm vessel,full of physiological saline,was inserted into the ventricle,whose outside was connected with the sensor through a 3-way stop cock.The sensor transformed the pressure into electrical signals and transmitted them to micro-computer C8051F020 for data processing.The value of pressure was then displayed on the LCD.Results Real-time and precise detection could be acquired by this intracranial pressure gage.Conclusion The digital intracranial pressure gage is easy-to-operate,simple and portable.

To make biomedical engineer comprehend deeply the cleaning and disinfection method of hemodialysis equipment,this paper discusses two factors determining cleaning and disinfection method,analyzes the impurities infecting dialysis' quality and treatment effect in hemodialysis system,and systematically introduces the daily cleaning and disinfection of hemodialysis equipment as well as its notice by citing Gambro AK95 series hemodialysis equipment.

In this paper,such information of argon-fluoride excimer laser is introduced as its principle,capacity,features and application to corneal refractive surgery.Its treatment effects and developing trend are also mentioned.

In this paper, the constitution and operation principle of an automatic ventilation system for excimer laser therapeutic instrument are introduced. With high accuracy, stability and reliability, the system benefits the performance and service life of the instrument.

Objective To develop a new optometer controlled by micro-computer.Methods With AT89C51 single-chip as hardware and programmed by C language,the instrument applied,the optometer adopted LCD and international standard optotype.The optotype had 14 lines of object-finders,and only one line of random characters was displayed on the screen every time.The optometry distance was 3m.All procedures were controlled by singlechip.Results The case of memorizing eye-chart was avoided and the optometry was every simple.Conclusion The instrument eliminates mirror used for optometry short distance,and the optometry results can be stored and printed.It also has the merits of small volume,precise manufacture,simple operation,low cost and AC/DC power supply.