Acute leukemia is one of the most common cancers among children.The biological mechanisms leading to leukemia have not been fully clarified until now.Experiments were improved that most patients developing acute leukemia had abnormal chromosomes,including TEL/AML-l,BCR/ABL,PML/RAR-α fusion genes,which would be potential clinical biomarkers.Many genetic polymorphisms have effect on acute lymphoblastic leukemia susceptibility,which were containing genes involved in folate metabolism pathways,cytochrome P450,glutathione-S-transferase enzymes and quinone oxidoreductase-1.As the results of the studies,alcohol,tobacco,TNF-α and IFN-γ might be risk factors to the disease.Furthermore infection and IRF-3 were reported to reduce the occurrence of acute leukemia.Finally,as more is learned about the molecular pathology,it may be possible to develop new therapeutic agents which are specifically targeted to treat childhood acute leukemia.

The medical image registration between preoperative three-dimensional (3D) scan data and intraoperative two-dimensional (2D) image is a key technology in the surgical navigation. Most previous methods need to generate 2D digitally reconstructed radiographs (DRR) images from the 3D scan volume data, then use conventional image similarity function for comparison. This procedure includes a large amount of calculation and is difficult to archive real-time processing. In this paper, with using geometric feature and image density mixed characteristics, we proposed a new similarity measure function for fast 2D-3D registration of preoperative CT and intraoperative X-ray images. This algorithm is easy to implement, and the calculation process is very short, while the resulting registration accuracy can meet the clinical use. In addition, the entire calculation process is very suitable for highly parallel numerical calculation by using the algorithm based on CUDA hardware acceleration to satisfy the requirement of real-time application in surgery.
Algorithms ; Humans ; Imaging, Three-Dimensional ; Tomography, X-Ray Computed ; X-Rays

STAT3 can be activated by various cytokines and participate in the process of tumor cells proliferation,angiogenesis,invasion and chemotherapy resistance.Epithelial-mesenchymal transition (EMT)also plays an important role in the process of tumor invasion and metastasis and chemotherapy resistance.Studies have shown that STAT3 can regulate the process of EMT so as to change the invasion and metastasis abilities of tumor cells,and to enhance their ability of chemotherapy resistance.Discussion of the role and relation of STAT3 and EMT in tumor cells will be helpful to provide reliable theory for tumor molecular targeted therapy.

Objective To analyze the quality of life(QOL)of patients with acute stroke,and to explore the effects of early specialized rehabilitation on their QOL.Methods Seventy patients with acute stroke were randomly divided into a rehabilitation group(n =35)and a control group(n =35).The rehabilitation group received specialized rehabilitation treatment while the control group received self-rehabilitation.QOL we evaluated with the short form-36(SF-36)instrument before and after.Results Before treatment,QOL scores in the both groups were much lower than the norms for healthy people.The differences on each dimension of the SF-36 were not statistically significant between the two groups.The SF-36 scores of both groups improved during the experiment,but after 1 month and 6 months the improvement on each SF-36 dimension was significantly better in the rehabilitation group than in the control group.Conclusions The QOL of patients with acute stroke is significantly impaired,but specialized rehabilitation treatment is effective in improving it.

Objective　To study the prognostic factors in cholangocarcinoma(CC). Methods　Retrospective analysis of the reported clinical data of CC in lectures. Results and Conclusions　The prognosis of CC in lower portion of bile duct(BD) is much better, CC in meddle portion of BD take the second place of prognosis, CC in upper portion of BD has the worst prognosis. If CC with following cases, which would have much better prognosis: higher differentiation without metastasis, diploid, higher PCNA; if CC with negative expression of epithelial membrane antigen or keratine, which would have worse prognosis. The activate of type IV collegen is related linearly to the metastasis capacity of the tumor, and the expression of nm23 of tumor is related to invation, lymphatic metastasis and prognosis of the tumor. Radical resection of the tumor has the best effect, palliative resection take the second place of prognosis, internal or external drainage operation has the worst effect. The effect of local radiotherapy is limited, and chemotherapy showes no effect. Early diagnosis, radical or extending resection and combined therapy can improve the prognosis of CC.

Objective To make a research on the expression of perlecan in the formation of epidural scar after posterior lumbar laminectomy in the rat.Methods Sixty Wistar rats were randomly and evenly divided into five groups:the experimental groups including A(the first week after surgery),B(the second week),C(the fourth week),D(the sixth week)and the control group.Laminectomy was performed on lumbar vertebra in each experimental group.The hematoxylin-eosin(HE)staining was used to observe the formation of epidural scar.Immunohistochemistry was performed to detect the perlecan located in the epidural scar.Western blot and RT-PCR were made to quantify the expression of the perlecan after surgery.Results According to HE,with prolonged,the scar tissue gradually formed.Immunohistochemistry demonstrated that the perlecan was expressed in the fibroblast.Western blot and RT-PCR showed the high level expression of perlecan in the experimental groups compared to the control group(P＜0.01).Furthermore,the expression of perlecan gradually increased with the prolongation of exposure time and had significantly statistical significance (P＜0.01)between the first three experimental groups.However,compared to the fourth week group,the expression of perlecan in the sixth week decreased obviously(P＜0.01).Conclusion Perlecan was expressed in the fibroblast of the epidural scar,and which plays an important role in the formation of epidural scar.

TCM boosts plenty theories and practice on delaying aging.Many TCM recognitions on the mechanism of female aging are still useful.The female has menstration,pregnancy,and lactation physiologically,which are different from the male,so the mechanism of the female aging is obviously different from the male.Many factors leads to female aging,such as the growth of age,interaction between deficiency,qi stagnation,blood stasis,and turbid phlegm,and results in functional retrogradation of the whole body.A deep discussion on the mechanism and law of female aging will bring about positive significance in the prevention and treatment of this disease.

Objective To study the regulative effect of angelica sinensis on cellular immune function in perioperative patients with obstructive jaundice. Methods Fourteen patients with obstructive jaundice were injected with angelica before and after operation for 14 days. The activity of IL-2 and the expression of IL-2R in lymphocytes in peripheral blood were measured, respectively. Results The activity of IL-2 and the expression of IL-2R decreased significantly in patients with obstructive jaundice (P

Role of chronic inflammation in type 2 diabetes and obesity has been recognized in the past few years. Examples of potent inflammatory cytokines are C-reactive protein (CRP),tumor necrosis factor-?(TNF-?) ,plasminogen activator inhibitor-1 (PAI-1) and interleukin-6 (IL-6). Inflammatory processes may have important roles in the development of type 2 diabetes,obesity and insulin resistance. This article reviewed the relationship between some inflammatory cytokines and diabetes, providing references for clinical diagnosis and treatment.