1.Study result on anti-radical actvity and membrane endurance of otgontenger resorts
Oldokh S ; Ambaga M ; Myagmarbaatar G ; Zorigtbaatar D
Mongolian Medical Sciences 2011;172(2):129-133
Introduction: Although the physic-chemical nature and compounds of Otgontenger spring have been relatively studied over the last years, no any substantial scientific work was done in regard to its therapeutic action and significance.It is known that during gastritis, chronic hepatitis and rheumatism macro and micro elements and biologically active compounds dramatically decrease within cells of each related organ and the processes of cell’s bioenergy, bio-synthesis, and re-synthesis [1.2] are imbalanced that leads to loss of cell’s divisibility and its rejuvenescence. Consequently, disbalance in blood coagulation, micro-circulation, ischemia, hypothermia, reperfusion substantial decrease of endurance to anti-oxidant deficiency and anti-radical activity weakness are observed. So, our study has been done basing on our hypothesis that macro and micro elements as well as biologically active compounds in Otgontenger resorts as sulphate ion (SO42-), azotes (N2), hydrosulfuric acid (H2S), oxygen (О2), carbonate ion (СO32-), chloral ion (CL-), hydrogen (Н2), carbonic acid (СО2,) could replace the biologically regulative agents which are cardinally shortened and becoming the main factor of pathologies [3. 4].Goal: The goal of this study is to investigate treatment activity “Otgontenger” resorts treatment experimental conditions. It is purposed to define the redoxy-potentiality and anti-radical activities of Otgontenger resorts.Materials and Methods: The study was conducted at the Central Scientific Laboratory of Monos Medical University between 2009-2011. Otgontenger mineral water was transported in a package accordingly to the Mongolian Standard “The Technical requirements to mineral water of treatment and drinking intent” (MNS 3651: 2005). In order to determine the anti-radical activity of the mineral water each portion of the studying water is dissolved in ethanol. After that 0.1 and 0.2 mlg are taken from these solutions and are added to 1.5 mlg of alfa, alfa-demetilpicril-gydralice suspension. The solution is shaken well and once color deeply changed it was defined at 517 HM through spectrophotometer by B.Yu. Kulikov’s method (1995, 1996). In regard to Osmos’s endurance property, 16 white experimental rabbits are taken by mouth 1.0 mlg/200 grams each from the mineral water number 1 of the 1st group, number 18th of the 4th group and number 47th of the 7th group respectively two times a day for the consecutive five days. The blood is taken and centrifuged in a way that serum is segregated and 0.5 mlg of 10 percent erythrocytes is separated. Consequently, 5.0 mlg of distilled water is added and hymolize is carried out. Once gymolize is fully done, supernatant is separated after centrifuge and absorption is measured at 420hm by spectrophotometer. In regard to defining hydropereoxide endurance, the white rabbit is taken by mouth 1.0 mlg/200 grams each from the mineral water number 1 of the 1st group, number 18th of the 4th group and number 47th of the 7th group respectively two times a day for the consecutive five days. The blood is centrifuged and serum is segregated. The blood is taken and centrifuged in a way that serum is segregated and 0.5 mlg of 10 percent erythrocyte is separated. Consequently, 3.0 mlg of Н202 is added and hymolize is carried out. Once gymolize is fully done, supernatant is separated after centrifuge and absorption is measured at 420hm by spectrophotometer.Results: It has been defined that antiradical activity in the erythrocytes’ 4th compartment of the white rabbits taken mineral water number 18th of the 4th group and number 1st of the 1st group increased by 1.11-1.12 times compared to the group not taken, whereas, decreased by 1.1 times by the impacts of the mineral water under 47th number of the 7th group (Table 1). It is shown that the mineral water has effects to increase proton flows at mitochondria membranes and donators’ oxidation, because antiradical activity of the second compartment of the rabbit’s erythrocytes has gone down by 1.13-1.16 times compared to the group not taken because of the mineral water under number 18 of the 4th group and number 1 of the 1st group and number 47 of the 7th group. If we see table 2 and picture 2, it is proved that mineral water has effects to accelerate oxygen flow to erythrocytes or acceptors’ diffusion and as well energy supply because membrane’s peroxide endurance of erythrocytes’ fourth compartment of the white rabbit decreased by 1.11-1.12 times under the influence of Otgontenger resorts number 18 and 1 of the 4th and 1st groups respectively and as well osmos’s endurance property of membrane of the erythrocytes’ 4th compartment decreased by 1.2-1.22 times compared to those not taken it. If we see picture 3, it is proved that mineral water has effects to accelerate oxygen flow to erythrocytes or acceptors’ diffusion and energy supply because membrane’s peroxide endurance of erythrocytes fourth compartment of the white rabbit decreased by 1.11-1.12 times under the influence of Otgontenger resorts with numbers 18 and 1 of the 4th and 1st groups respectively and as well osmos’s endurance property of membrane of the erythrocytes’ 4th compartment decreased by 1.2-1.22 times compared to those not taken it.From picture 4 it can be seen that under the influence of some types of Otgontenger mineral water as 18th number of the 4th group and the first number of the 1st group MDA contained in the second compartment of the white rabbit decreases by 1.11-1.12 times compared to the control group not taken and as well osmoses’ endurance of the erythrocytes’ 4th compartment membrane declines by 1.2-1.22 times which means they have effects to accelerate oxygen flow to erythrocytes or acceptors’ diffusion and consequently energy supply. We can see from picture 5 that under influence of mineral water with number 47 of the 7th group, the oxidise-ferment activity of erythrocytes’ second compartment serum has decreased two times for the control group compared to the ones not taken the mineral water. Moreover, the oxidise-ferment activity of erythrocytes’ first compartment declined by 1.2 times as a result of the mineral water with number 47 of the 7th group. That means that the mineral water suppresses the ferment activity of lipoproteidlipaza but makes the flow of redoxy-line protons accelerated.Conclusion: It has been defined that Otgontenger mineral water has high antitoxic effects to reduce free radicals like DPHH.
2.Identification of heat risk days in Ulaanbaatar city population’s health
Zorigtbaatar G ; Ariunbold S ; Gomboluudev P ; Burmaajav B
Mongolian Medical Sciences 2016;175(1):58-62
IntroductionAround for the last 70 years, an annual average temperature in Mongolian territory has been increasedby 2.14°Ñ which is 3 times more rapid than the global average warming rate. Also, the number of heatwave days have been increased [1, 2].Heat wave day’s leads to heat related morbidity and mortality. Espesially, stroke [3-5], cardiovascular [3-13] and respiratory [3, 5, 10, 12] mortalities are prevelant. Cardiovascular mortality has been determinedas a leading cause of mortality in our population while it takes the 3rd place [14] as a cardiovascularmorbidity.As the city of Ulaanbaatar houses 46% of Mongolian population, heat effects on health in the area andits trend need to be assessed, analyzed and identifi ed.PurposeTo identify heat risk days to health of the population of Ulaanbaatar city between the years of 1985through 2015Materials and MethodUnder the requirements set to sample, heat risk days with temperatures above 21.10C or 700F refl ectedon weather forecasts broadcasted from 1985 through 2015 by the Information And Research InstituteOf Meteorology, Hydrology And Environment, Mongolia have been selected. The afore mentioneddata have been translated into the heat index of National Weather Service of USA and processed andconcluded [15] according to the special formula and tables.ResultsIt is shown that heat risk days for the health of population of the Ulaanbaatar city had been 201 from1985 through 1995, 385 from 1996 through 2005 and 373 from 2006 through 2015. The average heatrisk days per given year varied in numbers from 4 through 56 and trended to increase. The largest heatwave days in number happened in the year of 2010 which is 56.According to health impacts of heat risk days, we had 0-47 Cautions, 0-17 Extreme Cautions and 2Dangers in the each of 1999 and 2005 and 1 in 2007 whilst no Extreme Danger has not been recordedyet.Conclusions:1. The number of heat risk days in the area of Ulaanbaatar tends to increase2. The number of Caution and Extreme caution days of Ulaanbaatar is observed to increase. Increaseof “Danger” tagged days, happening of “Extreme” tagged days and heat intense will depend onclimate change.
3.Climate change induced heat impact on human health
Zorigtbaatar G ; Ariunbold S ; Gomboluudev P ; Burmaajav B
Mongolian Medical Sciences 2016;175(1):83-95
This abstract is a brief summary of results of studies on climate change related potential health risks.Climate change is a phenomenon, which is resulted by a direct and indirect human-induced change inthe earth’s atmospheric composition during its natural course of variation.The main source of climate change is greenhouse gas emission in the atmosphere which is associatedwith human-related activities.One of the climate change’s effect is elevated atmospheric temperature or global warming which directlyaffects human health. There has been a direct link between a raise in the ambient temperature andcardiovascular morbidity cases sought medical assistances and increased cardiovascular mortality ratedetected. It is found to be that elderly; children and outdoor workers are susceptible to heat-stress duringhigh heats and heat waves. Also, media that, in terms of locations, tropical and sub-tropical countries arefound to be vulnerable to heat effects has pointed it out.Cardiovascular, respiratory and cerebrovascular diseases are commonly reported as the underlyingcause of death, because persons with these preexisting diseases are more susceptible to death duringheat waves and high temperature.Hypertensive, ischemic heart disease and stroke are prevalent contributors to cardiovascular mortality.Cardiovascular morbidity lines up in the 3rd place among the most common causes of the world humanmortality.Identifi cation of vulnerable groups during climate change is the most effective public health action whichis equally being critical in prevention. Therefore, initiate a public alert procedure on extreme heat eventssuch as high ambient temperature and consecutive heat wave days, as well as preventive measurestargeted on vulnerable groups are considered to be effective.
4. RESULT OF KASAI OPERATION, CHILDREN LIVER TRANSPLANTATION IN MONGOLIA
Chuluunkhuu D ; Zorigtbaatar M ; Nurjanar R ; Ganbayr L ; Otgonsuren G ; Dashaa M ; Enkhzul P ; Khandmaa B ; Sergelen O ; Bat-Ireedui B ; Ganzorig B ; Pagaldulam M ; Saruul G ; Tsendjav A
Journal of Surgery 2016;20(2):56-61
Introduction: Biliary Atresia is a fibroobliterativedisorder of the intra andextrahepatic bile ducts in infancy, which isgoing progressively cholestatic liver disease.The failed Kasaiportoenterostomy requiresliver transplantation. The goal of this studyis to show the outcome of Kasai operation,recent improvement and correlation the datato overseas.Methods and Materials: This study wasconducted in the department of generalsurgery of National Center for Maternal andChild Health of Mongolia between 2010 and2016 on a total of 66 infancies with biliaryatresia.Results: Patient diagnosed with biliaryatresia, which performed Kasai operationwithin first 2 months the outcome is verygood early and late post-operation period.There were 3 patients with 10 year survival, 4patients with 5-10 year and 28 patients with5 year survival after Kasai operation. The mostcomport age for liver transplantation is 1 yearlater after Kasai operation in Mongolia. Livertransplantation programme is necessary forMongolian pediatric surgery, and we thoughtour team was assembled.Conclusion: The children with biliary atresiaperform the Kasai operation within 2 monthsthe outcome is very good. Children with biliaryatresia often experience long wait times fortransplant unless exception points are grantedto reflect severity of disease.In Mongolia livertransplantation done in 2 child.