Objective To observe the changes of potassium ion (K+), lactic acid (Lac) and glucose (Glu) in swine with traumatic hemorrhagic shock (THS) inside the dry-heat environment and to explore its possible mechanism. Methods A total of 40 local Landrace piglets were randomly(random number) divided equally into 4 groups: the normal temperature sham operation group (NS), the normal temperature traumatic hemorrhagic shock group (NTHS), the dry-heat sham operation group (DS group) and the dry-heat traumatic hemorrhagic shock group (DTHS). The experiment was carried out in the artifi cia climate cabin simulated the special environment of northwest of China. After exposed to their respective environment[dry-heat environment: (40.5±0.5), plus(10±2)% humidity; normal temperature environment: (25±0.5), plus(35±5)% humidity] for 3 h. Laparotomy were performed in swine of all groups, and then splenectomy and partial hepatectomy were performed only in NTHS and DTHS. The process of exsanguination from the external iliac artery was established to make the MAP reaching to 40-50 mmHg, and thus the traumatic hemorrhagic shock model of swine was successfully made. Blood samples were collected from external iliac artery at different intervals including the time just after exposure for 3 h and the successful establishment of traumatic hemorrhagic shock model (0 h) and then every 30 min after 0 h, serum levels of K+, Lac and Glu were detected. The features of varied serum K+, Lac and Glu were observed in each group. All data were statistically analyzed using One-way ANOVA and Pearson correlation analysis. Results After exposed , the level of serum K+inside the dry-heat environment was higher than that of swine inside the normal temperature group ( P<0.01), however the Glu level was lower in the swine inside dry-heat environment than that of swine inside the normal temperature ( P<0.01).The level of serum K+and Lac of DTHS group were rapidly increased from the establishment of the model to the death in about 3 h, while those of NTHS group were increased slowly. The level of K+and Lac were positively correlated in the two groups amd the correlation coeffi cient were rDTHS=0.927 (P<0.01) and rNTHS=0.539 (P<0.01),respectively. The level of Glu was progressively decrease in DTHS group, while in NTHS group, it was not noticeable. The level of K+and Glu were negatively correlated in the two group, the correlation coeffi cient were rDTHS=-0.804 (P<0.01) and rNTHS=0.420 (P<0.01),respectively. Conclusions The changes of serum K+, Lac and Glu occurred sooner and more obvious in traumatic hemorrhagic shock models inside dry heat environment (DTHS) group than those in NTHS group. The level of serum K+positively correlated with Lac, however, negatively correlated with Glu, which suggested that hyperkalemia and acidosis should be paid more attention to the treatment of traumatic hemorrhagic shock inside the dry heat environment, and the hypoglycemia should be treated at the same time.

Objective To explore the influence of citalopram on early recovery of motor function in patients with acute cortical infarction.Methods A total of 276 patients with acute cerebral infarction were randomly divided into observation group and control group,138 cases in each group.Patients in control group were treated with anti-platelet,blood lipid,protective nerve and rehabilitation therapy.The observation group was given citalopram hydrobromide tablets on the basis of control group.Results The incidence rate of depression in the observation group was 18.1％,which was significantly lower than 42.7％ in the control group (P ＜ 0.05).After treatment,HDRS score and NIHSS score in the observation group were significantly lower than the control group (P ＜ 0.05).In the observation group,after treatment of 30 days and 90 days,the increasing scores of hand motor function of FMA were 4.1 ± 1.0 points and 6.5 ± 2.5 points,which were significantly higher than 1.4 ± 0.7 points and 2.5 ± 1.5 points (P ＜ 0.05).After treatment of 30 days,the BI score of observation group was significantly higher than control group (P ＜ 0.05).Conclusion Early application of citalopram can effectively reduce the incidence rate of post-stroke depression in patients with acute cerebral infarction,promote the recovery of motor function and improve the quality of prognosis.

Objective To explore the influence of citalopram on early recovery of motor function in patients with acute cortical infarction.Methods A total of 276 patients with acute cerebral infarction were randomly divided into observation group and control group,138 cases in each group.Patients in control group were treated with anti-platelet,blood lipid,protective nerve and rehabilitation therapy.The observation group was given citalopram hydrobromide tablets on the basis of control group.Results The incidence rate of depression in the observation group was 18.1％,which was significantly lower than 42.7％ in the control group (P ＜ 0.05).After treatment,HDRS score and NIHSS score in the observation group were significantly lower than the control group (P ＜ 0.05).In the observation group,after treatment of 30 days and 90 days,the increasing scores of hand motor function of FMA were 4.1 ± 1.0 points and 6.5 ± 2.5 points,which were significantly higher than 1.4 ± 0.7 points and 2.5 ± 1.5 points (P ＜ 0.05).After treatment of 30 days,the BI score of observation group was significantly higher than control group (P ＜ 0.05).Conclusion Early application of citalopram can effectively reduce the incidence rate of post-stroke depression in patients with acute cerebral infarction,promote the recovery of motor function and improve the quality of prognosis.