Objective To investigate the effects of combination of tandospirone,mosapride and Bella ray on the levels of oxygen free radicals and inflammatory cytokines in patients with reflux esophagitis.Methods From March 2016 to March 2017,ninety cases with reflux esophagitis treated in Nanchong Central Hospital were involved in this study.The patients were divided into the observation group and the control group according to different treatment methods,45 cases in each group.Patients in the observation group were treated with tandospirone and mosapride combined with ray Bella with treatment,patients in the control group were treated with Mosapride combined with Bella ray,the therapeutic effect of two groups were observed and compared,oxygen free radical and inflammatory cytokines before and after treatment of the two groups were compared.Results After treatment,MDA and AOPP of the patients in the observation group were(16.51±2.6)U/L and(36.5 ±4.5)μmol/L,significantly lower than those in the control group(MDA:(20.8±2.9)U/L,AOPP:(59.9 ±4.8)mol/L).Glutathione peroxidase(GSH-PX)and superoxide dismutase(SOD)in the observation group were significantly higher than those in the control group((249.4 ± 32.3)mg/L vs.(228.6 ± 17.2)mg/L, (27.3± 3.4)mg/L vs.(18.8 ± 2.7)mg/L),the differences were statistically significant(t=33.5,32.3, 31.4.32.7,P<0.05).After treatment,the levels of TNF-a,IL-6,IL-8 were significantly lower than those in the control group(17.7±2.8)μg/L vs.(26.3±1.5)μg/L,(4.9±0.3)ng/L vs.(6.5±1.8)ng/L,(5.4±0.7) μg/L vs.(6.6±0.8)μg/L),the differences were statistically significant(t=36.3,31.5,32.4,P<0.05).In the observation group,22 cases were significantly effective,19 cases were effective and 4 cases were ineffective, the effective rate was 91.1%,which was significantly higher than that of the control group(86.7%),(χ2=29.5,P=0.02).Conclusion Tandospirone combined with Bella ray can reduce the levels of oxygen free radicals and inflammatory cytokines in patients with reflux esophagitis.