7.Precision diagnosis and therapy of myelodysplastic syndrome based on disease nature and our facility
Zong-hong SHAO ; Hua-quan WANG
Tianjin Medical Journal 2018;46(8):785-788
The essence of myelodysplastic syndrome (MDS) is a malignant clonal bone marrow myeloid neoplasm. Both
basic researches and clinical studies should firmly grasp this essence of MDS and should not be interferenced by
confounding factors. Comprehensive diagnosis can improve the accuracy of MDS diagnosis by multiple indicators that reflect
the malignant nature, such as cell dysplasia, function abnormalities, cytogenetic changes and gene mutations. The therapy of
MDS should also eradicate the MDS clone, change the disease progression, stimulating normal hematopoiesis, prolong the
survival and improve the quality of life.
8.Research progress on the red cell diseases in China.
Chinese Medical Journal 2012;125(15):2746-2751
In recent years, there have been lots of progresses in the studies on red cell diseases in China, especially bone marrow failure diseases including immuno-related pancytopenia, aplastic anemia, myelodysplastic syndrome, and paroxymal nocturnal hemoglobinuria. Numerous laboratory experiments as well as clinical researches have been carried out by Chinese hematologists, which brought about much clearer pathogenesis, more rational diagnosis methods and more effective therapies for red cell diseases.
Anemia, Aplastic
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diagnosis
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epidemiology
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etiology
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metabolism
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China
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Hematologic Diseases
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diagnosis
;
epidemiology
;
etiology
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metabolism
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Hemoglobinuria, Paroxysmal
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diagnosis
;
epidemiology
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etiology
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metabolism
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Humans
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Myelodysplastic Syndromes
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diagnosis
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epidemiology
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etiology
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metabolism
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Pancytopenia
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diagnosis
;
epidemiology
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etiology
;
metabolism
9.Research about effect of spray drying conditions on hygroscopicity of spray dry powder of gubi compound's water extract and its mechanism.
Jie ZONG ; Qi SHAO ; Hong-Qing ZHANG ; Yong-Lan PAN ; Hua-Xu ZHU ; Li-Wei GUO
China Journal of Chinese Materia Medica 2014;39(4):663-668
OBJECTIVETo investigate moisture content and hygroscopicity of spray dry powder of Gubi compound's water extract obtained at different spray drying conditions and laying a foundation for spray drying process of Chinese herbal compound preparation.
METHODIn the paper, on the basis of single-factor experiments, the author choose inlet temperature, liquid density, feed rate, air flow rate as investigated factors.
RESULTThe experimental absorption rate-time curve and scanning electron microscopy results showed that under different spray drying conditions the spray-dried powders have different morphology and different adsorption process.
CONCLUSIONAt different spray-dried conditions, the morphology and water content of the powder is different, these differences lead to differences in the adsorption process, at the appropriate inlet temperature and feed rate with a higher sample density and lower air flow rate, in the experimental system the optimum conditions is inlet temperature of 150 degrees C, feed density of 1.05 g x mL(-1), feed rate of 20 mL x min(-1) air flow rate of 30 m3 x h(-1).
Desiccation ; methods ; Drugs, Chinese Herbal ; chemistry ; Hydrophobic and Hydrophilic Interactions ; Particle Size ; Powders ; chemistry ; Temperature ; Water ; analysis ; Wettability
10.Advances in the role of helper T cells in autoimmune diseases.
Xiao-Mei ZHANG ; Chun-Yan LIU ; Zong-Hong SHAO
Chinese Medical Journal 2020;133(8):968-974
Autoimmune diseases are primary immune diseases in which autoreactive antibodies or sensitized lymphocytes destroy and damage tissue and cellular components, resulting in tissue damage and organ dysfunction. Helper T cells may be involved in the pathogenesis of autoimmune diseases under certain conditions. This review summarizes recent research on the role of helper T cells in autoimmune diseases from two aspects, helper T cell-mediated production of autoantibodies by B cells and helper T cell-induced activation of abnormal lymphocytes, and provides ideas for the treatment of autoimmune diseases. The abnormal expression of helper T cells promotes the differentiation of B cells that produce autoantibodies, which leads to the development of different diseases. Among them, abnormal expression of Th2 cells and T follicular helper cells is more likely to cause antibody-mediated autoimmune diseases. In addition, abnormal activation of helper T cells also mediates autoimmune diseases through the production of abnormal cytokines and chemokines. Helper T cells play an essential role in the pathogenesis of autoimmune diseases, and a full understanding of their role in autoimmune diseases is helpful for providing ideas for the treatment of autoimmune diseases.