7.Research progress on the red cell diseases in China.
Chinese Medical Journal 2012;125(15):2746-2751
In recent years, there have been lots of progresses in the studies on red cell diseases in China, especially bone marrow failure diseases including immuno-related pancytopenia, aplastic anemia, myelodysplastic syndrome, and paroxymal nocturnal hemoglobinuria. Numerous laboratory experiments as well as clinical researches have been carried out by Chinese hematologists, which brought about much clearer pathogenesis, more rational diagnosis methods and more effective therapies for red cell diseases.
Anemia, Aplastic
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diagnosis
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epidemiology
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etiology
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metabolism
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China
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Hematologic Diseases
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diagnosis
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epidemiology
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etiology
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metabolism
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Hemoglobinuria, Paroxysmal
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diagnosis
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epidemiology
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etiology
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metabolism
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Humans
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Myelodysplastic Syndromes
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diagnosis
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epidemiology
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etiology
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metabolism
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Pancytopenia
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diagnosis
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epidemiology
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etiology
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metabolism
8.Research about effect of spray drying conditions on hygroscopicity of spray dry powder of gubi compound's water extract and its mechanism.
Jie ZONG ; Qi SHAO ; Hong-Qing ZHANG ; Yong-Lan PAN ; Hua-Xu ZHU ; Li-Wei GUO
China Journal of Chinese Materia Medica 2014;39(4):663-668
OBJECTIVETo investigate moisture content and hygroscopicity of spray dry powder of Gubi compound's water extract obtained at different spray drying conditions and laying a foundation for spray drying process of Chinese herbal compound preparation.
METHODIn the paper, on the basis of single-factor experiments, the author choose inlet temperature, liquid density, feed rate, air flow rate as investigated factors.
RESULTThe experimental absorption rate-time curve and scanning electron microscopy results showed that under different spray drying conditions the spray-dried powders have different morphology and different adsorption process.
CONCLUSIONAt different spray-dried conditions, the morphology and water content of the powder is different, these differences lead to differences in the adsorption process, at the appropriate inlet temperature and feed rate with a higher sample density and lower air flow rate, in the experimental system the optimum conditions is inlet temperature of 150 degrees C, feed density of 1.05 g x mL(-1), feed rate of 20 mL x min(-1) air flow rate of 30 m3 x h(-1).
Desiccation ; methods ; Drugs, Chinese Herbal ; chemistry ; Hydrophobic and Hydrophilic Interactions ; Particle Size ; Powders ; chemistry ; Temperature ; Water ; analysis ; Wettability
9.Precision diagnosis and therapy of myelodysplastic syndrome based on disease nature and our facility
Zong-hong SHAO ; Hua-quan WANG
Tianjin Medical Journal 2018;46(8):785-788
The essence of myelodysplastic syndrome (MDS) is a malignant clonal bone marrow myeloid neoplasm. Both
basic researches and clinical studies should firmly grasp this essence of MDS and should not be interferenced by
confounding factors. Comprehensive diagnosis can improve the accuracy of MDS diagnosis by multiple indicators that reflect
the malignant nature, such as cell dysplasia, function abnormalities, cytogenetic changes and gene mutations. The therapy of
MDS should also eradicate the MDS clone, change the disease progression, stimulating normal hematopoiesis, prolong the
survival and improve the quality of life.
10.Study on the pathogenesis of blood cytopenia in patients with systemic lupus erythematosus.
Rong FU ; Toukiko UEHARA ; Lu GONG ; Zong-Hong SHAO
Chinese Journal of Hematology 2008;29(1):48-51
OBJECTIVETo explore the pathogenetic mechanism of cytopenia in the patients with systemic lupus erythematosus (SLE).
METHODSTwenty-one patients with SLE and 10 healthy controls were enrolled in this study. Bone marrow mononuclear cells (BMMNC) Coombs test was used to determine the autoantibodies and in vitro CFU-E, BFU-E and CFU-GM yields were used to determine the proliferation function of hematopoietic stem/progenitor cell (HSC).
RESULTSPositive results of BMMNC-Coombs test were observed in 12 patients with SLE (57.1%), among them, 10 with (58.2%) and 2 without blood cytopenia. The yields of CFU-GM (49 +/- 40), and CFU-E (49 +/- 35) in SLE patients without cytopenia were higher than that in normal controls, but lower than that in cytopenia SLE patients. The BFU-E yield in SLE patients (3 +/- 4) was significantly lower than that in normal controls (36 +/- 12).
CONCLUSIONThere were auto-antibodies on BMMNC in patients with SLE. The blood cytopenia in SLE patients maybe resulted from the destructions of bone marrow hematopoietic cells by the autoantibodies. The capacities of bone marrow HSC in SLE patients for proliferation compensation of hematopoietic cell destruction were not damaged.
Adolescent ; Adult ; Autoantibodies ; blood ; Bone Marrow ; immunology ; pathology ; Bone Marrow Cells ; immunology ; pathology ; Case-Control Studies ; Female ; Humans ; Lupus Erythematosus, Systemic ; immunology ; pathology ; Male ; Middle Aged ; Young Adult