OBJECTIVETo investigate the enhancing effect of crystal sugar-vinegar solution on the tolerance of alcohol consumption in mice and rabbits.

METHODCrystal sugar-vinegar solution was given to mice or rabbits 30 min before feeding a dose of alcohol. The toxic behavior and percentage of animal death in 24 hours were observed. Meanwhile, blood alcohol levels in the rabbits were measured.

RESULTCrystal sugar-vinegar solution could prolong the latent period of righting reflex disappearing of the drunk mice(P < 0.01) and decrease death percentage of drunk mice in 24 hours(P < 0.01). Crystal sugar-vinegar could also decrease blood alcohol levels in the drunk rabbits, especially 30 min(P < 0.01) and 180 min(P < 0.05) after administration of alcohol.

CONCLUSIONCrystal sugar-vinegar solution has an evident sober-up effect on drunk model animal.

Acetic Acid ; therapeutic use ; Alcoholic Intoxication ; blood ; drug therapy ; Alcoholism ; blood ; drug therapy ; Alcohols ; blood ; Animals ; Carbohydrates ; chemistry ; therapeutic use ; Crystallization ; Drug Combinations ; Female ; Male ; Mice ; Rabbits