1.Investigation of nosocomial infection of medical elderly inpatients in our hospital
Chinese Journal of Disease Control & Prevention 2001;5(1):34-35
Objective To find out nosocomial infection of elde rly patients in our nosocomial and to provide theoretical evidence for preventing nosocomial infection of elderly patients. Methods 601 elderly p ati ents of internal medicine in our hospital were investigated with prospective and retrospective methods from January 1996 to December 1998. Results Nosocomial infectious rate in this age was 8.32%, and it was higher than mean nosocomial infectious rate in our nosocomial during the last three years( 1.48%). Infectious sites was mostly the lower respiratory tract, and it's infe ctious r ate was 52%. Basic diseases such as endocrine system, circulatory system, dige stive system, genitourinary system, respiratory system diseases were higher in nosocomial infection. Opportunitive pathogens were the main cause of the nosocomial infectious pathogens, and fungi took 85% of the opportunitive pa thogens. Conclusions Nosocomial infectious factors are mainly that immune function is lower in the aged and antibiotic is used generally.
2.Influence of intraoperative use of saline and balanced salt solution on nerve function recovery in patients with brain trauma
Ziyun GUO ; Xiongxin ZHANG ; Yuxiong LI
Journal of Regional Anatomy and Operative Surgery 2016;25(10):765-768
Objective To study the influence of intraoperative use of saline and balanced salt solution on postoperative nerve function recovery in patients with brain trauma.Methods Totally 120 patients were randomly divided into the saline group and the balanced salt solu-tion group,and the postoperative nerve function recovery of the two groups were observed.Results The level of pH and HCO3 -24 hours af-ter operation in the saline group were lower than those in the balanced salt solution group (P <0.05),while the level of Cl - in the saline group was higer than that in the balanced salt solution group (P <0.05).The intracranial pressure and preoperative Glasgow coma score (GCS)of the two groups had no statistical significance (P =0.94).And the Glasgow coma score at 336 hours and 672 hours after opreation of the two groups were of statistical significance (P =0.00,P =0.03).The mortality of the saline group and the balanced solution group 28days after surgery were 15% and 10% respectively,and there was no significant difference between the two groups (P =0.58).Conclusion Saline resuscitation during surgery would lead to hyperchloremic acidosis as well as worse nerve function.However,the perfusion of balanced salt solution during the operation is more favorable to the recovery of neurological function.
3.Treatment of transported trauma patients in China Wenchuan earthquake
Dali FAN ; Xiaoming ZHONG ; Dun LIU ; Yu CHEN ; Jun YANG ; Ying ZHAO ; Xiaoyi BAO ; Ziyun ZHONG ; Bing GUO
Chinese Journal of Trauma 2008;24(10):858-860
Objective To investigate the clinical characteristics of the wounded in Wenchuan earthquake transported to our hospital and summarize therapeutic experiences. Methods Clinical data of 92 patients resulted from Wenchuan earthquake admitted into our hospital were reviewed and analyzed in aspects of general data,injury severity,therapeutic methods and clinical results. Results All pa-tients were free from infection,reamputation and fracture-related complication. Conclusion After the arrival of large number of the wounded in the station hospitals.efficient organization of station hospitals,comprehensive evaluation of the patients'condition,effective detailed therapeutic plans and careful man-agement of the medical complications can attain sound results.
4.Application of liquid chromatography-tandem mass spectrometry in the clinical diagnosis and treatment of adrenal incidentaloma
Chinese Journal of Laboratory Medicine 2021;44(8):669-673
With the development of diagnostic techniques, the diagnosis rate of adrenal incidental tumors is increasing. Disease related hormones can be detected to evaluate the endocrine function of tumors for diagnosis and treatment, especially by liquid chromatography-tandem mass spectrometry (LC-MS/MS). LC-MS/MS has the advantages of high sensitivity, specificity and multi-component, and has become the gold standard method for the detection of small molecule hormones.Mass spectrometry has advantages in the detection of glucocorticoids, halo corticoids, sex hormones and catecholamine metabolites.LC-MS/MS still has some limitations in clinical practice, which are manifested as low degree of automation and lack of standardization.After the improvement of the clinical application of LC-MS/MS and the establishment of reference scope, the clinical judgment on the endocrine function of AI will be more standardized.
5.Third investigation and analysis of quality control situation of intensive care unit in traditional Chinese medicine hospitals in Sichuan Province
Jun CHEN ; Xiaobin LI ; Xingmei ZHONG ; Kunlan LONG ; Lijia ZHI ; Xiangwen WENG ; Wenhui GUO ; Ziyun LUO ; Peiyang GAO
Chinese Critical Care Medicine 2019;31(7):896-899
Objective To evaluate the present development and status of quality control for intensive care unit (ICU) in Sichuan Provincial traditional Chinese medicine (TCM) hospitals including integrated traditional Chinese and western medicine hospitals and ethnic hospitals, and to provide practical references for improving the service quality of ICU. Methods Supervisory Group of Sichuan Provincial Critical Care Medicine Quality Control Center of TCM was established in September 2018. From September 8th to 17th, 2018, according to the Scoring Criteria of Quality Control and Supervision Project of TCM for Critical Care Medicine, a 10-day quality control professional guidance was hand out to TCM hospitals with independent ICU in Sichuan Province. The service level of different aspects of hospital quality control was evaluated and ranked from equipment and resource support, medical team, service capacity and level, ward quality, completion of critical care core indicators, completion of quality control of TCM, development of new technologies, diagnosis and treatment schemes for dominant diseases. Results There were 52 TCM hospitals across the province that had an ICU. Thirty-three hospitals were third-class (63.5%), while the rest 19 hospitals were second-class (36.5%). Province-level, city-level and county-level hospitals were accounted for 9.6% (5/52), 38.5% (20/52), and 51.9% (27/52), respectively. Average bed ratio of ICU was 1.8%. Doctor-bed and guard-bed ratios were 0.71∶1 and 2.0∶1, respectively. The average annual admission rate of patients and the average daily admission rate of beds were higher, which were basically 1%. Ward quality was high; the incidence of nosocomial infection was controlled below 10%. Compliance rate of septic shock bundle treatment was high. The incidences of ventilator-associated pneumonia (VAP), catheter-related bloodstream infection (CRBSI) and catheter-associated urinary tract infection (CAUTI) were 0.45%, 0.22%, and 0.30%, respectively. Participation rate of TCM was about 83.4%. Average number of new technologies was about 4.4. Average number of disease schemes was about 2.62. Conclusions ICU of Sichuan Provincial TCM hospitals reaches the standard level in service capacity and level, ward quality, critical medicine quality control, and participation rate of TCM treatment. Improvements are required for other prospects, including department scale, medical personnel allocation, new technical development, diagnosis and treatment schemes of dominant diseases.
6.Role of apical sodium-dependent bile acid transporter in hepatobiliary diseases
Xiaoxuan XIE ; Lina DU ; Ziyun GUO ; Yan YANG
Journal of Clinical Hepatology 2024;40(1):199-203
Apical sodium-dependent bile acid transporter (ASBT) is a key transporter responsible for intestinal reabsorption of bile acid and plays an important role in maintaining bile acid and cholesterol homeostasis, and its expression is regulated by various factors including transcription factors, nuclear receptors, and intestinal microflora. The abnormal expression and function of ASBT can lead to disorders in the metabolism of bile acid and cholesterol, causing a variety of hepatobiliary diseases. At present, ASBT has attracted wide attention as a therapeutic target. This article elaborates on the biological characteristics and expression regulation mechanism of ASBT and reviews the role of ASBT in hepatobiliary diseases, in order to provide a new direction for the treatment of related diseases.
7.Nutritional assessment and treatment management of infantile cholestatic liver disease
Lina DU ; Lulu XIA ; Jie YAN ; Ziyun GUO ; Yan YANG
Journal of Clinical Hepatology 2022;38(1):228-232
Children with infantile cholestatic liver disease are often accompanied by malnutrition, which in turn can affect its progression and prognosis. There are many factors causing malnutrition and various methods for malnutrition assessment, but there is still a lack of uniform standard for nutritional assessment in patients with liver diseases, and a variety of indicators and methods are required for comprehensive analysis and assessment. This article analyzes the common causes of malnutrition in children with cholestatic liver disease, introduces the different methods for nutritional assessment, including anthropometric measurements, laboratory examination, and nutritional assessment tools, and elaborates on nutritional intervention treatment, so as to improve the understanding of nutritional problems in children with cholestatic liver disease. Early identification and rational interventions can help to improve the quality of life and prognosis of children.
8.Recovery of proprioception after lateral ankle sprain
Renjie XU ; Zhou LI ; Yuting GUO ; Xiqin YU ; Jingming MA ; Xiangyang GE ; Ziyun ZHU ; Yuxin ZHANG ; Feng ZHOU
Chinese Journal of Rehabilitation Theory and Practice 2023;29(7):844-848
ObjectiveTo observe the recovery of proprioception of the affected ankle over time after lateral ankle sprain accepting routine rehabilitation. MethodsFrom June, 2020 to June, 2022, 18 patients with lateral ankle sprain in Kunshan Rehabilitation Hospital underwent routine rehabilitation for twelve weeks. They were measured active and passive position sense of bilateral ankles using an isokinetic dynamometer before treatment, and four, eight and twelve weeks after treatment, respectively. ResultsThe active presentation difference of affected ankle reduced after treatment (F = 22.533, P < 0.001), but it was more than that of the healthy ankle at the same time (t > 4.419, P < 0.001). No significant improvement was found in passive presentation difference of affected ankle after treatment (F = 1.175, P > 0.05), and it was not significantly different from those of the healthy ankle at the same time (|t| < 0.646, P > 0.05). ConclusionProprioception of affected ankle has been impaired after lateral ankle sprain, and it can be recovered after rehabilitation, but cannot achieve the healthy level even after three months of training. Passive position sense as an index of proprioception needs more researches.