1.Treatment of Postoperative Recurrence and Metastasis of Gastric Cancer Based on the Theory of "Controlling Channels and Collaterals"
Ziyu KUANG ; Jiaxi WANG ; Jie LI
Journal of Traditional Chinese Medicine 2024;65(15):1611-1616
Based on the theory of "controlling channels and collaterals", this paper expounds the role of channels and collaterals system in the recurrence and metastasis of gastric cancer after surgery, and puts forward the prevention and treatment idea of warming the yang qi of channels and collaterals to consolidate the essence, and removing the stasis and blockage of channels and collaterals to clear the source. In the process of pattern differentiation and treatment, attention should be paid to the influence of surgery and cold medicinals on the yang qi of middle jiao. The yang qi of middle jiao should be supplemented to warm yang and strengthen vessels to prevent chuanshe (metastasis); the channels and collaterals with pathogens should be opened to remove its stasis and blockage, and the cancer toxin should be attacked to clear the source and flow, and also the cancer toxin should be given a way out to prevent its accumulation and carcinogenesis; At the same time, envoy medicinals should be given to guide the effects of other herbs to specific channels, so as to induce the medicinals to reach the internal organs through the meridians; to achieve the organic combination of macroscopic differentiation and microscopic differentiation, and the organic combination of zang-fu pattern differentiation and channel pattern differentiation, and it is also a further extension of the treatment method of consolidating the root and clearing up the source, in the hope that it can provide reference for the pattern differentiation and treatment of recurrence and metastasis of gastric cancer after surgery.
2.Ideas for Prevention and Treatment of Postoperative Recurrence and Metastasis of Gastric Cancer Based on the Theory of “Chuan-she”(传舍) and “Yang Deficiency and Toxic Knot”
Ziyu KUANG ; Jiaxi WANG ; Luchang CAO ; Jie LI
Journal of Traditional Chinese Medicine 2023;64(22):2300-2304
Based on the theory of “chuanshe”, this paper expounded the role of yang deficiency and toxic knot as the core pathogenesis in various aspects of gastric cancer recurrence and metastasis after surgery, and put forward the prevention and treatment ideas of recurrence and metastasis of gastric cancer by conjugating yang to curb the trend of “transmission (chuan)”, protecting the yang to prevent metastasis by settling its “residence (she)”, preventing immersion by warming the yang to block the way of “chuan-she”, and attacking and cutting to clear the pathogen of cancer and poison and eliminate the root of the disease. In the process of preventing and treating recurrence and metastasis after gastric cancer surgery, the three methods of conjugating yang, protecting yang and warming yang should be flexibly used based on the principle of treating yang; combined with attacking and removing cancer poison, differentiating syndromes and diseases ; meanwhile, the changes of cold and heat in the body should be identified in detail and treated by the syndromes, in order to provide reference for the clinical differentiation and treatment of recurrence and metastasis after gastric cancer accurately.
3.Analysis of Traditional Chinese Medicine Syndrome Characteristics and Related Factors of Yang Deficiency Syndrome in Postoperative Gastric Cancer Patients: A Multicenter Cross-Sectional Study
Yuansha GE ; Ruike GAO ; Jie LI ; Bowen XU ; Jingyuan WU ; Luchang CAO ; Ziyu KUANG
Journal of Traditional Chinese Medicine 2024;65(24):2565-2571
ObjectiveTo explore the distribution characteristics of traditional Chinese medicine (TCM) syndromes in postoperative gastric cancer patients, and to analyse the factors associated with yang deficiency syndrome and its severity. MethodsTotally, 173 patients who underwent postoperative gastric cancer surgery and were treated in four centers nationwide from February 22, 2022 to March 21, 2023, were enrolled. General information and TCM syndromes were collected, and Diagnostic Scale for Yang Deficiency Syndrome in Gastric Malignancies was filled in. The frequency of TCM syndromes after gastric cancer surgery was analyzed, and univariate analysis and multivariate logistic regression analysis were performed on the related factors of yang deficiency syndrome versus non-yang deficiency syndrome and between different severity of yang deficiency syndrome. ResultsThe most common syndrome after gastric cancer surgery was qi deficiency (95 cases, 54.91%), followed by yang deficiency (87 cases, 50.29%). Patients with yang deficiency syndrome were often suffered from qi deficiency, qi stagnation, and phlegm dampness syndrome. Comparing yang deficiency syndrome with non-yang deficiency syndrome, univariate analysis showed that history of alcohol consumption, pathological stage, degree of differentiation, Lauren grade, signet ring cell carcinoma, vascular cancer thrombus, and nerve invasion were statistically significant (P<0.05); and multivariate logistic regression analysis showed that history of alcohol consumption, signet ring cell carcinoma, pathological stage Ⅲ, Ⅳ, and vascular cancer thrombus may be correlated with yang deficiency syndrome in postoperative gastric cancer patients (P<0.05). The univariate analysis showed that age, pathological stage, precancerous lesions, and body mass index grade were significantly different when compared between mild and severe yang deficiency syndrome (P<0.05); multivariate logistic regression analysis showed that age, low body weight, and pathological stage Ⅲ and Ⅳ might be correlated with severe yang deficiency syndrome after gastric cancer surgery (P<0.05). ConclusionQi deficiency and yang deficiency are common TCM syndromes in postoperative patients with gastric cancer. Alcohol consumption history, pathological staging (stage Ⅲ and Ⅳ), signet ring cell carcinoma, and the presence of vascular cancer thrombus may be correlated with the occurrence of yang deficiency syndrome, and higher age, low body weight, and pathological staging (stage Ⅲ and Ⅳ) may be the correlates of severe yang deficiency syndrome.
4.Clinical analysis of 1 057 patients with critical illnesses in a dermatological ward
Hai LONG ; Li JIANG ; Yueqi QIU ; Nan YAO ; Licong LIU ; Yuming XIE ; Feng XIONG ; Siqi TAN ; Qiqi KUANG ; Ruixuan YOU ; Ke CHAI ; Xin LUO ; Haojun LONG ; Yue XIN ; Ziyu GUO ; Jiaqi WANG ; Yixin TAN ; Qing ZHANG ; Guiying ZHANG ; Yaping LI ; Yuwen SU ; Rong XIAO ; Qianjin LU
Chinese Journal of Dermatology 2021;54(9):790-797
Objective:To summarize clinical characteristics of and treatment experience with patients with critical illnesses in a dermatological ward.Methods:All patients with serious or life-threatening conditions, who were hospitalized at the dermatological ward of the Second Xiangya Hospital of Central South University from July 9, 2011 to December 31, 2020, were collected, and their clinical data were retrospectively analyzed. Demographic characteristics, disease types and proportions, main complications, causes of serious or life-threatening conditions, important treatment measures and outcomes were summarized, and causes of death were also analyzed and discussed.Results:A total of 1 057 patients with critical illnesses were collected, with a male-to-female ratio of 1∶1.11, and 64.81% of them aged 18 to 65 years. The types of diseases mainly included drug eruptions (332 cases) , connective tissue diseases (226 cases) , bullous skin diseases (104 cases) , psoriasis (57 cases) , erythroderma (45 cases) , infectious skin diseases (67 cases) , etc. Among them, psoriasis (39 cases) and erythroderma (32 cases) mostly occurred in males, and connective tissue diseases (168 cases) mostly occurred in females. Common complications mainly involved infections, important organ damage or dysfunction, hypoalbuminemia, and fluid, electrolyte and acid-base imbalances. A total of 94 patients were diagnosed with life-threatening conditions, which were found to be mainly caused by primary skin diseases, hematologic abnormalities, respiratory failure, nervous system abnormalities, renal failure, sepsis, fluid, electrolyte and acid-base imbalances, etc. During the management of critical illnesses, 43 patients were treated with high-dose glucocorticoid pulse therapy, 264 were treated with gamma-globulin pulse therapy, 355 were transfused with other blood products, and 34 received special therapies such as hemoperfusion/immunoadsorption therapy, plasma exchange, dialysis, artificial liver support therapy; 42 patients were transferred to the intensive care unit (ICU) , 12 were transferred to the department of surgery for operations, and 12 were transferred to the department of obstetrics and gynecology for delivery or induction of labor. After treatment, 989 patients (93.57%) achieved improvement and were discharged. A total of 14 patients (1.32%) died, of whom 7 died of secondary sepsis, 2 died of severe pulmonary infections, 2 died of asphyxia caused by respiratory mucosa shedding-induced airway obstruction, the other 3 died of gastrointestinal hemorrhage, cerebral hemorrhage and neuropsychiatric systemic lupus erythematosus, respectively.Conclusions:Critical cases in the dermatological ward mainly suffered from serious skin diseases such as severe drug eruptions, connective tissue diseases and bullous skin diseases, as well as complications such as severe underlying diseases, severe organ dysfunction, sepsis or severe fluid, electrolyte and acid-base imbalances. In terms of treatment, it is of critical significance to make a clear diagnosis and assess the severity of disease as early as possible, monitor and prevent possible complications, and to consult with specialists in relevant disciplines in time.