Objective: To investigate the expressions of Fas, FasL in papillary adenocarcinoma of thyroid gland tissues and their tumor infiltrating lymphocytes(TIL), and its relationship with apoptosis and Fas, FasL in thyroid tumors.Methods: We detected the apoptotic rate and the expression of apoptotic related gene Fas in 43 cases of papliiary adenocarcinoma of thyroid gland with flow cytometry. The expression Fas and FasL were measured in 43 cases of papillary adenocarcinoma of thyroid gland, 28 cases of thyroid adenoma,43 paplillary adenocarcinoma of thyroid gland TIL,17 thyroid adenoma TIL using flow cytometry.Results: 19 cases in papillary adenocarcinoma showed low expression of Fas protein with an average apoptotic rate of 3.71% and 24 cases had high expression of Fas with an apoptotic rate of 7 26%(P

With the development of systemic therapy for the treatment of breast cancer, the incidence of brain metastases from breast cancer is gradually increasing. Treatment with surgery,stereotactic radiosurgery, and wholebrain radiotherapy (WBRT) are still the first-line therapies for the majority of patients with brain metastases. Recently, chemotherapy, hormone therapy and targeted therapy have been widely used for breast cancer. This review summarizes the efficiency of those strategies for the breast cancer patients with brain metastases.

Background and purpose:The prognosis of high grade gliomas remains poor, and multidisciplinary treatment strategy has been much investigated recently. This study was to explore the efficacy of Temozolomide as first-line treatment combined with radiotherapy and followed by adjuvant chemotherapy for the treatment of newly diagnosed high grade gliomas. Methods:18 patients who had been pathologically proven to be high grade gliomas were enrolled into the study. The patients received 40 Gy/20fractions for the whole brain and followed by 20Gy/10fractions as a boost to tumor bed. All of the patients were given daily oral temozolomide 75mg/ m2 during radiotherapy. 4 weeks after radiotherapy, all of the patients received 6 cycles of Temozolomide, each cycle lasted 5 days with 28 days interval between each cycles. 150 mg/m2 of temozolomide was given for the first cycle for five days,followd by 200 mg/m2 of drug for the rest of the cycles if no significant drug related toxicities were observed. Results:Median follow-up was 12.5 months, 11 cases had either recurrence or progression, 5 of them died from the disease. The median time for disease progression-free survival was 9.8 months (95% CI, 6.1~9.8months), the median time for overall survival was 14 months (95% CI, 8.5 ~ 19.5months), 1-year overall survival rate was 55.6% ,6-month progression-free survival rate was 81.8%. there were no severe temozolomide related toxicities. Conclusion: Concurrent temozolomide with radiotherapy and followed by 6 cycles of temozolomide in the treatment of high grade gliomas had better clinical efficacy, the patients tolerated the strategy well and no severe toxicities were observed.

Acupuncture ; history ; manpower ; organization & administration ; History, 20th Century ; History, 21st Century ; Humans ; Maryland ; Medicine, Chinese Traditional ; history ; United States

Objective:To investigate frequency of blood stasis syndrome(BSS) defined by traditional Chinese medicine in cerebral infarction and its correlations with carotid atherosclerotic plaque(CAP).Methods: All subjects comprised 151 patients aged 40 to 80 years(Mean ? SD age,65 ?11 years) with 67.9% for males and 32.1% for females.With the use of ACUSON7 color Doppler ultrasound,carotid atherosclerosis was evaluated by the plaque score,the left plaque score,the right plaque score,the numbers of the plaque respectively as defined by the sum of all plaque heights in bilateral carotid arteries.On the basis of neurological signs and symptoms,medical history,and brain MRI,we diagnosed stroke and its subtypes as follows: stroke(n=117),and vertebrobasilar insufficiency(VBI)(n=34) without the history of the stroke,which were based on Diagnostic Criteria for Cerebral Vascular Diseases in 2005.Diagnosis for syndromes defined by traditional Chinese medicine were made according to Diagnostic Criteria for Stroke in 1994.One-way ANOVA was used in comparison between groups,and multivariant Logistic Regression Analysis was conferred in correlations between several variables.Results: 47.0% of all cases with cerebral infarction presented the BSS,with as lower than syndrome of fire-heat(51.0%),as but significantly higher than syndrome of Qi deficiency(32.0%),liver-wind syndrome(27.0%),phlegm syndrome(23.0%) and syndrome of asthenic yin causing predominant yang(6.0%).There is a significant difference between groups for 44(79.0%) cases of 56 patients with cerebral infarction and the BSS have CAP,and only 35(57.0%) cases of 61 patients with cerebral infarction but without the BSS have CAP(P

Acupuncture ; history ; legislation & jurisprudence ; California ; History, 20th Century ; History, 21st Century ; Humans ; Medicine, Chinese Traditional

Objective To investigate the effect of breast conserving surgery on neurotensin (NTS) and its receptor 1(NTR1) in patients with breast cancer.Methods From May 2012 to May 2015,200 patients with breast cancer,aged 44.7 years(range,32-56 years),were treated at Tiantan Hospital,Capital Medical University.All patients were divided into control group (n =100) and observation group (n =100).The patients in the control group were treated with radical operation and the patients in the observation group were treated with breastconserving surgery.The positive rate of NTS and NTR1 before and 1 week after operation,WHOQOL-100 (It includes four aspects:physiological state,psychological state,environmental condition and social function) 1 d before surgery,3 months and 6 months after surgery,and the incidence of postoperative complications 1 week after surgery were compared between the two groups.Measurement data with normal distribution were described as mean± standard deviation (Mean ± SD) and analyzed by the t test.Count data were analyzed by chi-square test.Results The positive rate of NTS (17.00％) in the observation group was significantly lower than that in the control group (36.00％) (t =9.267,P =0.002),The positive rate of NTR1 (19.00％) was significantly lower than that in the control group (33.00％) (t =5.094,P =0.024).The physiological status,psychological state,environmental condition and social function of 3 months after surgery of the observation group were (62.57 ± 5.73),(63.48 ±5.91),(68.73 ±6.32),(64.06 ±5.94) scores,respectively,and the control group were (53.47 ±5.38),(55.62 ±5.54),(60.38 ±6.14),(55.86 ±5.66) scores,respectively,showing statistically significant differences between the two groups (P ＜ 0.05).The physiological status,psychological state,environmental condition and social function of 6 months after surgery were (73.74 ±t 6.19),(76.27 ± 6.32),(78.85 ±6.77),(73.53 ±6.58) scores in the observation group,and (64.18 ±5.67),(67.38 ±6.02),(69.64 ± 6.43),(63.28 ± 6.17) scores in the control group,showing statistically significant differences between the two groups (P ＜ 0.05).The incidence of postoperative complications in the observation group (6.00％) was significantly lower than that in the control group (18.00％) (P ＜ 0.05).Conclusion Breast conserving surgery can reduce the expression level of NTS and NTR1 in breast cancer patients,It is related to reducing the incidence of postoperative complications and improving the quality of life of patients.

Objective:To explore the effect of hip arthroscopy on improving the cross-sectional kinematics of the lower limbs in patients with femoral acetabular impingement (FAI).Methods:Eight FAI patients who underwent hip arthroscopy in the Department of Sports Medicine of Peking University Third Hospital from October 2021 to February 2022 were prospectively included, including 3 males and 5 females, with an age of 35.3±13.0 years (range 17-53 years), height of 168.0±12.8 cm (range 154-192 cm), weight of 61.1±8.5 kg (range 52-74 kg) and body mass index of 21.7±2.6 kg/m 2 (range 17.6-24.5 kg/m 2). There were 3 left hips and 5 right hips. FADIR (flexion, adduction and internal rotation test) was positive in all patients and FABER (flexion, abduction and external rotation test) was positive in 4 patients. Modified Harris hip score (mHHS) and visual analogue scale (VAS) of the affected hip joint were compared before the surgery and at the follow-up of 10 months. By using a markerless motion capture system, foot progression angles during normal gait, double-leg squat, forward lunge, single-leg standing and stepping in place were measured and compared before the surgery and at the follow-up of 10 months postoperative results. Results:All the 8 patients underwent the surgery successfully and were followed up for 11.0±1.2 months. The mHHS scores before the surgery and at the follow-up of 10 months were 60.9±20.5 vs. 82.9±7.3 with significant difference ( t=-3.07, P=0.018). The iHOT-12 scores before the surgery and at the follow-up of 10 months for the affected hips were 51.4±23.7 vs. 79.2±14.6 with significant difference ( t=-3.76, P=0.007). The VAS scores before the surgery and at the follow-up of 10 months were 4.6±2.3 vs. 1.5±0.9 with significant difference ( t=3.16, P=0.016). There was no significant difference in foot progression angle between the healthy side and the affected side for all movement trials before the surgery and at the follow-up of 10 months ( P>0.05). During normal gait, the postoperative and preoperative foot progression angles for the healthy side and the affected side were 26.52°±5.97 vs. 34.4°±7.20° and 24.41°±3.70° vs. 30.80°±6.43°with significant reduction ( t=2.83, P=0.013; t=3.05, P=0.041). While there was no significant difference in foot progression angles for double-leg squat, forward lunge, single-leg standing and stepping in place before the surgery and at the follow-up of 10 months ( P>0.05). Conclusion:Hip arthroscopy can change the cross-sectional kinematic characteristics of the lower limbs, potentially improving the progression angle in FAI patients.