Objective To understand the level of posttraumatic growth among people living with HIV/AIDS and analyze the influencing factors. Methods Totally 175 people living with HIV/AIDS were randomly selected via convenience sampling and investigated using patients′ general information, Post-Traumatic Growth Inventory(PTGI), HIV stigma scale and Social Support Rating Scale. Results The average score of PTGI among people living with HIV/AIDS was (60.76 ± 27.03) points. Single factor analysis showed that there was a difference among people living with HIV/AIDS who had different education status, health insurance and whether to tell others HIV positive (Z=21.534, t=2.607, 3.958, P<0.01). There was a difference between the level of social support and perceived discrimination among people living with HIV/AIDS (r=0.245-0.275, P<0.01). Multiple linear regression analysis showed that the level of social support, perceived discrimination and whether to tell others HIV positive could affect the total score of PTGI. All the variables could explain 24.0％variance of posttraumatic growth. Conclusions People living with HIV/AIDS havemoderate posttraumatic growth. The level of social support, perceived discrimination and whether to tell others HIV positive are related to the posttraumatic growth among people living with HIV/AIDS.

Objective To describe the status of serf-disclosure among youth students living with HIV/AIDS and explore its influencing factors.Methods Totally 110 youth students living with HIV/AIDS in the outpatient clinic were randomly selected from three hospitals in Beijing via convenience sampling and investigated using patients' general information questionnaire,self-disclosure questionnaire,simplified coping style scale,medical and social support scale,self-esteem scale and HIV/AIDS knowledge questionnaire.Logistic regressions were used to determine the influencing factors of self-disclosure.Results Sixty-four youth students living with HIV/AIDS conducted serf-disclosure,accounting for 58.2％.Logistic regression results showed that the influencing factors of self-disclosure were marriage,test results of latest CD4 cell count,perceived discrimination.Conclusion The level of self-disclosure among youth students living with HIV/AIDS is relatively high in this study.Medical staff should know the status and influencing factors of self-disclosure among youth students living with HIV/AIDS,and make effective assessments and take targeted interventions in order to promote self-disclosure.

Objective:To investigate the optimal gestational weight gain (GWG) in dichorionic twin pregnancies.Methods:We conducted a retrospective analysis on 755 uncomplicated dichorionic twin pregnancies delivered at Peking University Third Hospital from August 2011 to December 2019. All participants were classified into three groups according to their pre-pregnancy body mass index (BMI), including underweight (BMI<18.5 kg/m 2, n=40), normal weight (BMI=18.5-24 kg/m 2, n=509), and overweight/obese (BMI≥24 kg/m 2, n=206) groups. Gestational BMI, rate of assisted reproduction, and the velocity of GWG were compared between the three groups using analysis of variance, Chi-square test and Kruskal-Wallis test. Regression model of GWG with the increase of gestational weeks was established using random effects model combined with restricted cubic spline to evaluate the percentiles of maternal weight gain during 4-39 gestational weeks. Results:The median of total GWG in the underweight, normal weight, and overweight/obese groups were noted for 17.0 (15.0-20.5) kg, 17.0 (14.0-21.0) kg, and 15.0 (12.0-20.0) kg, respectively, which decreased with the increase of pre-pregnancy BMI ( χ 2=11.974, P=0.002). The regression model fit well with the weight gain during different gestational weeks, which revealed that the weight gain was slow before 13 weeks of gestation, and kept at a steady speed thereafter, regardless of the pre-pregnancy BMI. The median and quartile ( P25- P75) of weight gain were 17.6 (15.2-20.3) kg, 17.3 (14.7-20.2) kg, and 15.7 (12.9-18.8) kg at 37 weeks in the underweight, normal weight, and overweight/obese groups, respectively. Conclusions:GWG of twin pregnancy changes slowly in the first trimester, and increases at a constant rate after the second trimester regardless of pre-pregnant BMI. Overweight/obese pregnancies have lower GWG.

Objective:To constructe an evaluation index system for clinical research innovation in medical institutions, for references for enhancing the research and innovation capabilities of medical institutions and formulating policies related to clinical research innovation.Methods:From March 2022 to May 2023, relevant literature and policies on the evaluation system of scientific and technological innovation at home and abroad were analyzed to establish the preliminary screening clinical research innovation indicators. Two rounds of Delphi method were used to construct a clinical research innovation index evaluation system, analytic hierarchy process was used to calculate the weights of each indicator.Results:The effective response rates of the two rounds of consultation questionnaires were both 100.00%, with expert authority coefficients of 0.95 and Kendall coordination coefficients of 0.85 and 0.87, respectively. The clinical research innovation index evaluation system ultimately established 4 primary indicators, 13 secondary indicators, and 42 tertiary indicators. The first level indicators included infrastructure construction, innovation support environment, clinical research activity, and innovation effectiveness, with weight coefficients of 18.00%, 21.00%, 30.00%, and 31.00%, respectively.Conclusions:The clinical research innovation evaluation index system constructed in this study covered the investment, environment, and output aspects of research innovation, and could comprehensively and objectively reflect the clinical research innovation ability of medical institutions.

ObjectiveWe examined the principal respiratory pathogens in patients with acute respiratory tract infection in Taizhou， Zhejiang Province during 2020‒2021 to provide evidence for prevention， diagnosis and treatment of acute respiratory tract infection. MethodsFrom September 2020 to August 2021， a total of 2 831 cases with acute respiratory tract infection were collected from two influenza sentinel surveillance hospitals in Taizhou， which had then received the examination of 22 respiratory pathogens by multiple fluorescence quantitative PCR. ResultsThe total positive rate of respiratory pathogens in 2 831 samples was 14.13%， among which enterovirus （7.77%） and respiratory syncytial virus （1.59%） were the principal pathogens. Except enterovirus， there was no significant difference in the positive rate of pathogens detected by gender（P>0.05）. Moreover， there was significant difference in pathogens by age （P<0.05）， with the highest positive rate in 0‒4 years（35.21%）. There was also significant difference in pathogens by seasons （P<0.05）， with the highest positive rate in summer（20.54%）. ConclusionThe positive rate of acute respiratory tract infection decreases significantly， compared with that before the COVID-19 epidemic. The differences in the positive rate differ significantly by age and seasons. Comprehensive consideration of diverse factors before diagnosis and the utilization of multiple fluorescent quantitative PCR can quickly and effectively determine the pathogens in the early stage of infection. Our findings may provide certain support for the diagnosis and treatment of acute respiratory infections in the context of COVID-19 in Taizhou.