Objective To evaluate the efficacy and safety of contrast-enhanced ultrasound-guided radio-frequency ablation in the treatment of liver cancer by meta-analysis.Methods The clinical controlled trial studys on the application of contrast-enhanced ultrasound guided radiofrequency ablation(the experimental group)and conventional ultrasound and enhanced CT guided radiofrequency ablation(the control group)for liver cancer published in the databases of Pubmed Embase,Web of Science,Cochrane Library,China National Knowledge Infrastructure(CNKI),VIP,and Wanfang were retrieved.The search period was from database establishment to July 20,2023.meta-analysis on the included datas were performed.Results A total of eight studies involving 879 patients were included.Meta-analysis showed that there were significant differences in the complete ablation rate(OR=2.96,95％CI:2.13-4.11,P＜0.01),recurrence rate(OR=0.35,95％CI:0.22-0.55,P＜0.01)and postoperative complications(OR=0.49,95％CI:0.32-0.76,P＜0.01)between the two groups.Conclusion Contrast-enhanced ultrasound guided radiofrequency ablation is more effective than conventional ultrasound or enhanced CT in the treatment of liver cancer.