1.Pharmacodynamics Studies of Yinyanjing Gel in the Treatement of Bacterial Vaginitis in Rats
Zishan LI ; Rongrong WANG ; Ruilian LI ; Yali WU
China Pharmacist 2015;(8):1389-1391
To study the bacteriostat, anti-inflammatory and relieving itching effects of Yinyanjing gel. Methods: A double dilution method was used to detect the in vitro bacteriostat effect of Yinyanjing gel. The therapeutic effects of Yinyanjing gel on bacterial vaginitis were observed in rats. The antipruritic effect of Yinyanjing gel was observed in guinea pigs. Results:MIC for Staphy-lococcus aureus was 47. 39 mg·ml-1 , and that for Escherichia coli was 189. 59 mg·ml-1 . The therapeutic effects of Yinyanjing gel on bacterial vaginitis were significant. Yinyanjing gel showed notable antipruritic effect on the itching induced by histamine phosphate in guinea pigs. Conclusion:Yinyanjing gel exhibits significant effects of bactriostasis,anti-inflammation and relieving itching.
2.Intervention of BCG Polysaccharide and Nucleic Acid in Hypersusceptibility in Guinea Pigs
He TANG ; Ruilian LI ; Zishan LI ; Jiehu OUYANG ; Rongrong WANG
China Pharmacist 2015;(3):394-396,397
Objective:To study the effect and underlying mechanism of BCG polysaccharide and nucleic acid ( BCG-PSN) in hy-persusceptibility in guinea pigs to explore the improvement method for the quality control model of BCG-PSN. Methods:The ovalbumin induced hypersusceptibility animal model was established, the effect of BCG-PSN on hypersusceptibility in guinea pigs was observed. According to the guideline for immunity toxicity study on Chinese traditional medicine and natural medicine, the hypersusceptibility tests were carried out. Serum IgE and histamine were determined by ELISA. Results:The guinea pigs in the model group and the low dosage BCG-PSN group showed strong anaphylactic symptoms, while the middle and high dosage BCG-PNS groups showed fewer symp-toms. The level of IgE in the model group was (1. 673 0 ± 0. 158 6) μg·ml-1 and (1. 683 1 ± 0. 228 1)μg·ml-1 before and after the attacking, respectively, which was higher than that in the control group(P<0. 01). The levels of IgE in the middle and high dos-age BCG-PNS groups were decreased compared with those in the model group before and after the attacking(P<0. 01). The same re-sults were observed in the levels of histamine. Before and after the attacking, the levels of histamine in the model group was (1. 499 7 ± 0. 133 1) ng·ml-1 and (1. 512 1 ± 0. 050 6) ng·ml-1 , respectively, while the levels of histamine in low, middle and high dos-age BCG-PNS groups were decreased compared with those in the model group before and after the attacking(P<0. 01). Conclusion:BCG-PSN can dose-dependently inhibit the anaphylactic reaction induced by ovalbumin.
3.Effect of Motor Imagery on Balance Ability in Hemiplegics after Stroke
Yanning YAN ; Yaping HUAI ; Cuiluo LIU ; Zishan JIA ; Guifang YAN ; Zhongli WANG ; Zengxin SUN
Chinese Journal of Rehabilitation Theory and Practice 2008;14(1):55-56
Objective To study the effect of motor imagery on balance rehabilitation in hemiplegics after stroke.Methods 20 hemiplegic patients who were in chronic stage(above 6 months)were randomly divided into two groups.Normal rehabilitation was performed in the whole stage and motor imagery was added in group A in stage Ⅰ and group B in stage Ⅱ.All patients were assessed with Berg Balance Scale(BBS),blance subscale of the Fugl-Meyer Assessment(FM-B),max affected limb-loading per weight and Functional Independence Measure(FIM)at the beginning and the ending of the every stage,respectively.Results The deference scores of BBS and FIM,as well as max affected limb-loading per weight between in the stage with motor imagery was better than those in the stage without motor imagery(P<0.01),as well as that of FM-B score(P<0.05).Conclusion Motor imagery can improve balance rehabilitation and activity of daily living in chronic hemiplegics.
4.Effect of Ankle-Foot Retractor on Ankle Joint Motion and Equilibrium Function of Stroke Hemiplegic Patients
Guifang YAN ; Zhongli WANG ; Yu YIN ; Yanning YAN ; Zishan JIA ; Zengxin SUN ; Lanxin SONG ; Mingwei HUANG
Chinese Journal of Rehabilitation Theory and Practice 2011;17(8):737-738
Objective To study the effects of ankle-foot retractor on ankle joint motion and equilibrium function of stroke hemiplegic patients.Methods 74 patients were divided into two groups: observation group (n=36) and control group (n=38). The control group was trainedby routine rehabilitation training program and electro-uprise bed, the observation group was trained by ankle-foot retractor based on routinerehabilitation training program. The effect was evaluated after 8 weeks. Results After training, either the observation group or the controlgroup showed significant improvement at motion of ankle joint, activity of daily living (ADL), and equilibrium function, but the observationgroup was better than the control group (P<0.001). Conclusion Ankle-foot retractor plays a positive role on motion of ankle joint, ADL andequilibrium function in stroke patients.
5.Test Scale of Boston Diagnostic Aphasia Examination - Chinese Version.A Preliminary Summary of 105 Aphasics’ test result
Jie WANG ; Qingli ZHANG ; Yanling LV ; Zishan JIA ; Dahai TIAN ; Ping ZHANG ; Huijie XIE ; Haiqin KONG
Chinese Journal of Rehabilitation Theory and Practice 1996;2(3):111-116
cases of aphasics were tested by using Test Scale of Boston Diagnostic Aphasia Exami-nation- Chinese Version. The result shows.This scale has a good role in diagnosing various aphasia syn-drome and can be used to observe the changes of various language functions.
6.Application of diffusion tensor imaging in tracking visual pathway fiber bundles in postoperative intensity-modulated radiotherapy for cerebral gliomas
Chaoyun ZHAO ; Minglei WANG ; Xinshe XIA ; Yanhong GUO ; Zishan LIU ; Shengyu SUN ; Jianguo ZHAO ; Hui MA ; Xiaodong WANG ; Hechun XIA
Chinese Journal of Radiation Oncology 2016;25(4):315-319
Objective To analyze the feasibility of incorporation of tracking visual pathway fiber bundles by diffusion tensor imaging ( DTI) in computed tomography ( CT) simulation to develop a protective radiotherapy regimen for cerebral gliomas.Methods A total of 31 patients with cerebral gliomas who were admitted to our hospital from 2013 to 2015 and planed to receive postoperative radiotherapy were enrolled as subjects.All patients underwent CT simulation, conventional or contrast-enhanced magnetic resonance imaging, and DTI.The obtained DTI images of visual pathway fiber bundles were fused with 3DT1 anatomical scans and then imported into the treatment planning system.A protective treatment plan ( setting the entire visual pathway fiber bundles as organs at risk (OARs)) and a conventional treatment plan were made for intensity-modulated radiotherapy ( IMRT) .Comparison of treatment outcomes was made by paired t test.Results There were no significant differences in the conformity index and heterogeneity index of the planning target volume between the two treatment plans ( P=0.875,0.597), both of which had sufficient radiation doses to the target volume and conventional OARs protected.For the patients undergoing the protective treatment plan, the Dmax and Dmean values were reduced to 9.01%and 9.05%, respectively, in the ipsilateral optic tract and to 17.96%and 15.52%, respectively, in the contralateral optic tract;the Dmax and Dmean values were reduced to 5.37%and 5.48%(P=0.000), respectively, in the ipsilateral optic radiation tract and to 12.89%and 11.21%( P=0.000) , respectively, in the contralateral optic radiation tract.Conclusions The protective treatment plan based on CT simulation combined with the display of visual pathway fiber bundles by DTI can reduce the radiation dose to the entire visual pathway fiber bundles, which keeps the risk of visual dysfunction after radiotherapy as low as possible.
7.Study on the aging change of postural control reaction time and movement time during adaptive balance
Yusheng WANG ; Zishan JIA ; Gongzi ZHANG
Chinese Journal of Rehabilitation Medicine 2024;39(5):675-680,686
Objective:To observe the aging-related trends and age-sensitive changes in postural control reaction time(RT)and movement time(MT)during the adaptive balance after instability. Method:A total of 97 healthy adult subjects aged 20-79 were tested for posture control time using the DE-A somatosensory balance detection system.The test included postural adjustment RT and MT during the adaptive balance(e.g.forward,backward,left and right)tilts of the support surface under static and dynamic balance states.The subjects were sequentially divided into six age groups based on 10-year age intervals,with 16 in Group 1(20-29 years),10 in Group 2(30-39 years),17 in Group 3(40-49 years),18 in Group 4(50-59 years),31 in Group 5(60-69 years)and 5 in Group 6(70-79 years).The age-related trends and age-sensitive changes in postural control RT and MT were observed and analyzed. Result:The postural control RT and MT increased with age.In static balance,all RT and MT indicators were longer in group 6 than in groups 1 to 5,with significant differences compared with groups 1 to 4(P<0.05)but no significant differences compared to group 5(P>0.05).All RT and MT indicators were longer in group 5 than in groups 1 to 4,and there were significant differences(P<0.05).All RT and MT indicators were lon-ger in group 4 than in groups 1 to 3,with a significant difference compared with group 1 in RT when the support surface was tilted to the right(P<0.05),but no significant differences between groups for the remain-ing indicators(P>0.05).All RT and MT indicators were longer in group 3 than in groups 1 to 2,with a sig-nificant difference compared with group 1 in MT when the support surface was tilted to the left(P<0.05),but no significant differences between groups for the remaining indicators(P>0.05).There was no significant difference(P>0.05)between group 2 in all RT and in MT compared with group 1.In dynamic balance,all RT and MT indicators were longer in group 6 than in groups 1 to 5,with significant differences compared with groups 1 to 4(P<0.05)but no significant differences compared with group 5(P>0.05).All RT and MT indicators were longer in group 5 than in groups 1 to 4,but there were no significant differences(P>0.05).All RT indicators were longer in group 4 than in groups 1 to 3,with no significant differences compared with group 1 in RT when the support surface was tilted to the left(P>0.05),while there were significant dif-ferences between groups for the remaining RT indicators(P<0.05).All MT indicators were longer in group 4 than in groups 1 to 3,with significant differences compared with group 2 in MT when the support surface was tilted to the back and left(P<0.05),while there were no significant differences between groups for the remaining RT indicators(P>0.05).All RT indicators were longer in group 3 than in groups 1 to 2,with no significant differences compared with group 1(P>0.05).All MT indicators were longer in group 3 than in groups 1 to 2,with significant differences compared with group 1(P<0.05).There was no significant differ-ence between group 2 in all RT and in MT compared with group 1(P>0.05). Conclusion:The postural control RT and MT during the adaptive balance after instability gradually increase with aging.The deterioration of postural control response time and motion time in static balance may start to become evident around the age of 60,while in dynamic balance,these deteriorations may begin to appear around the ages of 50 and 40,respectively.