1.Predictive effect of age-adjusted Charlson comorbidity index on the risk of falls in elderly patients with femoral neck fractures
Ziruo ZHANG ; Jing HU ; Sitong YAN ; Peipei LI ; Hong ZHI ; Yuanyuan FENG ; Zhouqi JI
Chinese Journal of Modern Nursing 2024;30(11):1477-1482
Objective:To analyze the predictive value of age-adjusted Charlson comorbidity index (ACCI) on the risk of falls in elderly patients with femoral neck fractures.Methods:This study was a retrospective cohort study. From June 2021 to June 2022, cluster sampling was used to select 1 050 patients with femoral neck fractures at the Honghui Hospital affiliated with Xi'an Jiaotong University as the study subject. This study calculated the total ACCI score based on patient comorbidities, and divided patients into a low-risk fall group ( n=282) and a high-risk fall group ( n=768) based on whether the fall risk factor assessment score was ≥4.This study compared the differences in age, gender, American Society of Anesthesiologists (ASA) grading, ACCI score, white blood cell count, red blood cell count, platelet count, lymphocyte count, serum albumin, hemoglobin, creatinine, and urea nitrogen between the two groups. Independent variables with P<0.05 were included in binary Logistic regression to analyze the factors affecting the risk of falls in patients, and a receiver operating characteristic (ROC) curve was plotted. Results:There were statistically significant differences in age, ASA grading, red blood cell count, lymphocyte count, ACCI score, serum albumin, hemoglobin, creatinine, and urea nitrogen between the two groups of patients ( P<0.05). Logistic regression analysis found that age, ASA score, and ACCI score were independent risk factors for fall risk ( P<0.05), while serum albumin was an independent protective factor for fall risk ( P<0.05). The area under the ROC curve of ACCI for predicting fall risk was 0.892, and a score of 4 in ACCI was the cutoff value for predicting fall risk. Conclusions:ACCI can serve as an auxiliary tool for evaluating and predicting the risk of falls in elderly patients with femoral neck fractures, and can provide reference for clinical screening of high-risk individuals for falls.
2.Challenges and considerations in implementing enhanced recovery after surgery nursing for patients with hip fractures
Sitong YAN ; Ziruo ZHANG ; Peipei LI ; Cuicui LI ; Jing HU ; Wei HUANG
Chinese Journal of Modern Nursing 2024;30(6):701-706
This paper reviews the current status, problems, challenges, and considerations of enhanced recovery after surgery (ERAS) nursing for hip fracture patients in China, and systematically elaborates on the ERAS nursing programs, nursing pathways, and quality evaluation standards for hip fracture patients in China. In response to the challenges of differentiated starting, difficult clinical practice, and incomplete quality evaluation system in implementing ERAS nursing for hip fracture patients in China, suggestions are proposed to focus on national policies, standardize basic service content, optimize perioperative treatment and nursing processes for elderly hip fracture patients, strengthen the construction of ERAS nursing teams, and implement full cycle process management.
3.Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice.
Jinliang WANG ; Lei SHUAI ; Chong WANG ; Renqiang LIU ; Xijun HE ; Xianfeng ZHANG ; Ziruo SUN ; Dan SHAN ; Jinying GE ; Xijun WANG ; Ronghong HUA ; Gongxun ZHONG ; Zhiyuan WEN ; Zhigao BU
Protein & Cell 2020;11(10):776-782
Adaptation, Physiological
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Adenosine Monophosphate
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administration & dosage
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analogs & derivatives
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pharmacology
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therapeutic use
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Administration, Intranasal
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Alanine
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administration & dosage
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analogs & derivatives
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pharmacology
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therapeutic use
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Animals
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Betacoronavirus
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genetics
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physiology
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Chlorocebus aethiops
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Coronavirus Infections
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drug therapy
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virology
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Disease Models, Animal
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Female
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Host Specificity
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genetics
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Lung
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pathology
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virology
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mutation, Missense
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Nasal Mucosa
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virology
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Pandemics
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Pneumonia, Viral
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drug therapy
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virology
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RNA, Viral
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administration & dosage
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genetics
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Turbinates
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virology
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Vero Cells
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Viral Load
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Virus Replication