Objective:To explore the effect of Wagner grade home follow-up management of diabetic foot led by specialist nurses.Methods:From January 2017 to December 2018, convenience sampling was used to select 241 patients with type 2 diabetes and Wagner grade 0 diabetic foot in the Endocrinology Department of the First Affiliated Hospital of Xinxiang Medical University. According to the enrollment time, 113 patients with Wagner grade 0 diabetic foot enrolled from January to December 2017 were set as the control group, and 128 patients with Wagner grade 0 diabetic foot enrolled from January to December 2018 were set as the observation group. The control group implemented routine home care management, and the observation group carried out the Wagner grade home follow-up management of diabetic foot led by specialist nurses. Both groups were followed up for 18 months. The blood glucose index, Scale of the Diabetes Self-care Activities (SDSCA) score and foot prognosis were compared between the two groups.Results:After the intervention, the fasting blood glucose and glycosylated hemoglobin of the observation group were lower than those of the control group, and lower than those before the intervention, and the SDSCA score was higher than that of the control group, and higher than that before the intervention, the differences were statistically significant ( P<0.05) . At the end of the sixth month, the observation group had no patients in grade 4 and grade 5, had more people in grade 0 to 1 than in the control group, and fewer people in grade 2 to 3 than in the control group, and the difference was statistically significant ( P<0.05) . At the end of the twelfth and eighteenth months, the observation group had more people in grades 0 to 1 than in the control group, and fewer in grades 2 to 3 and 4 to 5 than in the control group, and the difference was statistically significant ( P<0.05) . At the end of the eighteenth month, there were no deaths in the two groups, and 6 patients with surgery, and 1 patient with amputation in the control group, and 1 patient with surgery and without amputation in the observation group. Conclusions:The Wagner grade home follow-up management of diabetic foot led by specialist nurses can effectively improve the patient's blood glucose control level, self-management ability, and delay the progress of diabetic foot.