Phytochemical studies of the the herb Sarcopyramis bodinieri var. delicate (Melastomataceae) have been carried out. The compounds were separated by repeated D101 macroporous adsorption resin column combined with Sephadex LH-20, ODS, and silica gel chromatgrophy. The structures were identified on the basis of extensive spectroscopic data analysis, and by comparison of their spectral data with those reported. Eight flavonoid compounds isolated from the ethyl acetate extract was identified as isorhamnetin (1), quercetin (2), isorhamnetin-3-O-beta-D-glucopyranoside (3), quercetin-3-O-beta-D-glucopyranoside (4), isorhamnetin-3-O-(6"-acetyl)-beta-D-glucopyranoside (5), isorhamnetin-3-O-(2"-acetyl)-beta-D-glucopyranoside (6), quercetin-3-O-(6"-acetyl)-beta-D-glucopyranoside (7), and quercetin- 3-O-(6"-O-E-p-coumaroyl)-beta-D-glucopyranoside (8). All of the compounds were separated from the genus of Sarcopyramis for the first time.
Flavonoids ; analysis ; isolation & purification ; Magnetic Resonance Spectroscopy ; Melastomataceae ; chemistry ; Spectrometry, Mass, Electrospray Ionization

Objective To assess the efficacy and safety of mifepristone combined with oral or vaginal misoprostol for termination of pregnancy between 8 and 16 weeks of gestation. Methods This was a randomized, multi-center, open clinical trial. A total of 625 women at 8-16 weeks of gestation were randomized to receive 200 mg oral mifepristone followed by either oral misoprostol 400 μg every 3 hours or vaginal misoprostol 400μg every 6 hours for a maximum of 4 doses 36-48 hours later. There were 417 women in oral group with 198 at 8-9 weeks and 219 at 10-16 weeks, while 208 women in vaginal group with 99 at 8-9 weeks and 109 at 10-16 weeks. The outcome measures were the success abortion rate, induction to abortion interval, the amount of bleeding, reoccurrence of menstruation and adverse events. Results Abortion rate was significantly higher in vaginal group [98.1% (202/206)] than that in oral group [94.0%(390/415), P=0.023]; concerning termination of pregnancy at 8-9 weeks and 10-16 weeks respectively, there were no significant differences between oral and vaginal groups (P=0.156, P=0.073). The induction to abortion interval was no significant difference in oral and vaginal group in different gestational weeks ( P=0.238, P=0.273). The average induction to abortion interval was (4.1 ± 6.6) hours and (6.0 ± 4.5) hours respectively in terminating 8-9 weeks and 10-16 weeks of gestation. Concerning the amount of bleeding within 2 hours of placenta expulsion, there was significant difference between oral group [(63±46) ml] and vaginal group [(55 ± 45) ml] in terminating 8-9 weeks of gestation (P=0.047), while there was no significant difference between groups in terminating 10-16 weeks of gestation [oral group (76 ± 52) ml versus vaginal group (76 ± 61) ml, P=0.507]. The reoccurrence of menstruation was about 37 days in both oral and vaginal groups. Two cases of incomplete abortion were serious adverse events (SAE) relating to treatment. The common adverse events (AE) of nausea and vomiting were significantly higher in oral group [57.2% (239/417), 36.3% (151/417)] than those in vaginal group [45.4% (94/208), 26.1% (54/208); P=0.005, 0.011]. Conclusion Oral or vaginal misoprostol combined with mifepristone, is effective and safe for termination of pregnancy between 8 and 16 weeks of gestation.

Objective? To explore the status quo and influencing factors of self-care ability of patients after laryngectomy, and to provide evidence for the formulation of targeted interventions in clinical practice. Methods? Using convenience sampling method, 126 patients who underwent laryngectomy for the first time in ENT & HN Surgery Department, Beijing Tongren Hospital, from January to December 2018 were selected as the research objects. The Exercise of Self-Care Agency (ESCA) was used in the study. Results? The total ESCA score of 126 patients after laryngectomy was (110.37±16.05). Univariate analysis showed that there were significant differences in ESCA scores among patients with different educational background, living conditions, place of residence, income and knowledge of laryngectomy (t=105.971, 2.173, -3.937, 41.166, 10.499;P＜0.05). Multivariate linear regression analysis showed that education level and income were the influencing factors of the self-care ability of laryngeal cancer patients after laryngectomy. Conclusions? The self-care ability of laryngeal cancer patients after laryngectomy is at a high level. Nurses can explain and demonstrate according to the characteristics of different patients, and further improve the self-care ability of laryngeal cancer patients after laryngectomy.

Objective To explore the effects of WeChat-based continuing nursing on swallowing function in partial laryngectomy patients. Methods From August 2016 to August 2018, we selected 64 partial laryngectomy patients of Beijing Tongren Hospital as subjects by convenience sampling. Patients were divided into observation group (n=30) and control group (n=30) with the random number table. Control group adopted routine discharge instruction. Observation group carried out the intervention by WeChat platform. The intervention effects were evaluated with the swallowing rehabilitation training knowledge questionnaire for partial laryngectomy patients, swallowing function training compliance questionnaire, water swallow test (WST). Results Three months after discharge, the score of swallowing rehabilitation knowledge of patients in the observation group was higher than that in the control group; the swallowing training compliance in the observation group was better than that in the control group;the differences were statistically significant (P＜0.05). One and three months after discharge, the scores of WST of the observation group were lower than those of the control group with statistical differences (P＜0.05). Conclusions WeChat-based swallowing function continuing nursing for partial laryngectomy patients can enhance patients' swallowing rehabilitation training knowledge and compliance to improve patients' swallowing function which is worthy of clinical reference and application.

Objective:To explore the effects of health coaching technique on continuous nursing for patients with laryngopharyngeal reflux disease (LPRD) .Methods:Totally 114 LPRD patients from Beijing Tongren Hospital, Capital Medical University between July 2015 to December 2018 were selected by convenient sampling and randomized into the experimental group ( n=56) and the control group ( n=58) . Patients in the control group received routine care, while patients in the experimental group received continuous nursing with the health coaching technique on this basis. Reflux Symptom Index (RSI) , Reflux Finding Score (RFS) and the compliance behavior questionnaire for LPRD patients were used to evaluate the effects of intervention. Results:The compliance scores in the experimental group at 1 and 3 months after discharge were higher than those in the control group, and the differences were statistically significant ( P<0.01) . There was no statistically significant difference in the RFS and RSI scores between the two groups on admission ( P>0.05) ; the RFS and RSI scores in the experimental group were lower than those in the control group 3 months after discharge from the hospital, and the differences were statistically significant ( P<0.01) . Conclusions:The application of health coaching technique to continuous care of patients with LPRD after surgery can improve the patient's compliance behavior as well as their prognosis.

Objective To explore the differences between baduanjin and ninth set of broadcast gymnastics in their own pulse parameters before and after intervention for 12 weeks,and to provide objective indicators for the function of Baduanjin from the perspective of pulse diagnosis.Methods 60 healthy subjects were recruited,and 50 subjects were finally included according to the dropout criteria.The subjects were divided into the experimental group and the control group by the random number table method,and different interventions were adopted.Then,the pulse diagnosis of the two groups of subjects was collected,and the impact of the interventions on the viscera was judged by analyzing the Pulse Graph Parameters and contribution.Results The characteristic parameters of the experimental group include 8 time domain parameters(left Chi,left Guan,right Cun,etc.)and 9 frequency domain parameters(left Guan,left Chi,right Guan,etc.),which are mainly distributed in the left Cun,left Guan,left Chi,and right Guan;the characteristic parameters of the control group included 6 time domain parameters(left Cun,left Guan,right Chi,etc.)and 11 frequency parameters(left Guan,left Chi,right Guan,etc.),which were mainly distributed in left Chi,right Chi,and left Guan.Conclusion Practicing Baduanjin can significantly affect pulse diagram,and the accuracy and specificity after intervention are higher than those of the control group.Baduanjin has a certain influence on the circulation of qi and blood in the human meridians,and its mechanism of action may be related to affecting the overall circulation of qi and blood.In the experimental group,Baduanjin had a significant effect on the heart,liver,gallbladder,and kidneys,while the control group had the most obvious changes in the kidneys.For the overall intervention and coordination of the viscera,the Baduanjin group had better effects than the ninth broadcast gymnastics group.