OBJECTIVE:To investigate the application of antibiotics in 2009 so as to provide reference for rational use of antibiotics in our hospital. METHODS:3 500 cases were randomly collected from our hospital in 2009 for statistical analysis of antibacterials application. RESULTS:Of 3 500 cases,2 580 cases involve antibacterials,accounting for 73.7%. Prophylactic application of antibiotics accounted for 39.6% and therapeutic application accounted for 60.4%. CONCLUSION:The application of antibacterials was improved to some extent and bacteria examination rate was increased significantly. However,there were still many problems,such as the abuse of antibacterials,unreasonable combination of antibacterials,low rate of bacterial detection.

0.91,no significant different was found between BMM and golden standard;t2,3=19.150,P

3 months. Female gender, adenocarcinoma history, non-smoking history, good PS and the presence of multiple lung metastases are associated with improved responsiveness to Gefitinib. Reflecting the results of previous clinical trials, the reports indicate that Gefitinib is generally well tolerated by Asian patients. The incidence of interstitial lung disease appears to be higher in Japanese than non-Japanese patients, although the reason for this is not clear. Recent findings regarding Erlotinib and other targeted therapy among Asian patients are discussed.

For advanced lung cancer,multimodality treatment is the main stream.Patients with locally advanced disease may have long-term survival rate with radiation therapy combined with chemotherapy.Patients with advanced metastatic disease may achieve improved survival and palliation of symptoms with chemotherapy.Here we reviewed the recent development in treatment for advanced non-small cell lung cancer.

The effect of Alternariol Monomethyl Ether (AME), a suspected carcinogen in human being, on the lipid peroxidation in the epithelia of fetal esophagus and stomach was studied. The epithelia of esophagus and stomach of human fetus induced labor with water-bag were treated with AME. Lipid peroxides were measured by thiobarbituric acid test for malondialdehyde (MDA). There was a positive correlation between the values of MDA levels and AME dosaeges. It demonstrated that the lipid peroxdation could be initiated with AME. Lipid peroxidation levels were increased following treatment time elongating. The values of MDA levels in esophagus were higher than those in stomach, which were treated with the same dosaege of AME. It showed that AME had an organ selectivity. These results indicate that AME may be one of genetoxic etiological factors of esophageal carcinoma in Linxian county.

Recent progress in molecular biology has enabled us to better understand the molecular mechanism underlying pathogenesis of human malignancy including lung cancer, the advent of therapies based on mechanisms that target critical molecular pathways of tumors has evoked considerable interest. The therapeutic index is high, and optimally effective treatment can be achieved at a dose below the maximal tolerated dose,giving us a better understanding of the human lung cancer. This review focuses on the advance of targeted therapy for the first-line, second-line treatment or the maintenance treatment of non-small cell lung cancer.

Aim To study the inhibition of glutathione-S-transferase by dihydromyricetin and its kinetics analysis in liver of mice.Methods Mouse liver cytochyma enzyme was obtained by different velocity centrifugation,the mouse liver glutathione-S-transferase of michaelis constant(Km),maximum velocity(Vmax)and the inhibition of glutathione-S-transferase by dihydromyricetin of 50% inhibiting concentration(IC50),inhibition constant(Ki),the type of inhibition were calculated by Lineweaver-Burk and the low of semi-effect-probit.Results It was found that dihydromyricetin inhibited the glutathione-S-transferase activity with an IC50 of(121.14?13.66)?mol?L~-1.Kinetics analysis showed the Km was 0.1460 mmol?L~-1 and Vmax was 175.44 U?mg~-1 for reduced glutathione(GSH)substrate and 0.0937 mmol?L~-1(Km)and 212.77 U?mg~-1(Vmax)for 1-chloro-2,4,-dinitrobenzene(CDNB)substrate.Kinetics studies of dihydromyricetin on glutathione-S-transferase showed the inhibition was competitive with GSH and noncompetitive with CDNB,and the inhibition constant was 0.22 mmol?L~-1 with GSH and 0.54 mmol?L~1 with CDNB.Conclusion Dihydromyricetin can inhibit the glutathione-S-transferase activity in liver of mice.

Objective To explore the effect of aspirin combined with clopidogrel bisulfate in the treatment of patients with acute cerebral infarction.Methods 486 patients with acute cerebral infarction were selected and divided into the two groups in accordance with the random number table,243 cases in each group.The control group were given aspirin and conventional medical treatment.The observational group were given aspirin and clopidogrel bisulfate orally,system hemorrhage and TT,PT,APTT,FIB of both group were monitored.The efficacy was analyzed in accordance with the degree of neurological deficits score.Results The NIHSS of the observational group after treatment [(6.38 ± 1.19) points] was significantly lower than that of before [(15.04 ± 2.53) points] (P ＜ 0.05);The NIHSS of the control group after treatment [(9.45 ± 3.27) points] was significantly lower than before [(16.26 ± 2.71) points] (P ＜ 0.05);The NIHSS after treatment in the observational group [(6.38 ± 1.19) points] was significantly lower than that of the control group [(9.45 ± 3.27) points] (t =8.264,P ＜ 0.05).The total effective rate of the observational group was 94.24％,which was significantly higher than 81.48％ of the control group(x2 =11.485,P ＜ 0.05).No system hemorrhage was found in both groups.The coagulation index after treatment was higher than before but still in relatively safe range.There was no significant difference of coagulation index between observational group and control group (all P ＞ 0.05).Conclusion Using aspirin combined with clopidogrel bisulfate in acute cerebral infarction patients is safe and effective.

Objective To study the effects of Xinkeshu capsule (mainly com po sed of Radix Salviae Miltiorrhizae, Radix Puerariae, Fructus Crataegi, Radix Not oginseng, Radix Auklandiae,etc.) on hemorheology of experimental atherosclerosis rabbits. Methods FASCO- 300 viscosity meter was used to detect whole blood v iscosity and plasma viscosity, hematocrit (Wen's tube) and erythrocyte sedimen tation (Wintrobe tube) were tested, and other items of hemorheology were exami ned. Results Xinkeshu capsule significantly inhibited the abnormal rise of who le blood viscosity, plasma viscosity, whole blood reduced viscosity, erythr ocyte aggregation index, erythrocyte sedimentation (ES), ES rate K, erythro cyte rigid index and Tk in the rabbits with atherosclerosis induced by high fat foodd( P

There are very close associations between traumatic and orthopedic teaching and medical imaging.Medical Imaging includes noumenal photograph,conceptual diagram,radiological imaging,operation photographic recording and computer-aided instruction courseware,etc.It is important to collect the medical imaging through various means and set up medical imaging resources library for traumatic and orthopedic teaching.