Objective:We conducted a meta-analysis of related studies to compare the prognostic effects of the Lobectomy and segmental resection procedures for stage ⅠA non-small cell lung cancer ≤2 cm.Methods:Relevant literatures were obtained from Pubmed, Web of Science, EMBASE, The Cochrane Library, CNKI, CBM, VIP and Wanfang databases. Inclusion and exclusion criteria were identified to screen articles for further systematic review and meta-analysis. Data related to segmentectomy group and lobectomy group were directly extracted or indirectly calculated from the included studies.Results:The current meta-analysis included 30 studies involving 12 227 patients published from the establishment of the database to 2022. Compared with lobectomy, segmentectomy had a significant benefit on 3-year OS in patients with NSCLC whose preoperative CT image was ≤2 cm ( OR=0.86, 95% CI: 0.75 - 1.00, P=0.05), there was no significant difference in 5-year OS ( OR=0.91, 95% CI: 0.76-1.09, P=0.30) 10-year OS ( OR=1.22, 95% CI: 0.67-2.21, P=0.51) among these patients. In the study of progression-free survival, patients had 3-year PFS ( OR=0.87, 95% CI: 0.67-1.13, P=0.30), 5-year PFS ( OR=0.87, 95% CI: 0.69-1.10, P=0.26), had no significant difference in PFS. In the subgroup analysis, there was no significant difference between the 3-and 5-year LCSS. Conclusion:Our findings suggest that lobectomy is not superior to segmentectomy for stage ⅠA NSCLC ≤2cm in terms of both long-term survival and progression-free survival, and may be the recommended surgical option. However, further randomized controlled studies and longer period of retrospective analysis are still needed for 10-year long-term survival and solid component analysis.

At present, the cats play a more and more important role in medical experiments as an experimental animal,especially for the studies of neurology,physiology and toxicology. Compared with rodent animals,the physiological characteristics, anatomical features, pathological and biochemical reactions of cats are closer to human beings, and compared with the primate animals,they have advantages of economy,abundant resources and so on. Therefore,cat has an extensive application prospect in animal models of human diseases. This article mainly reviews and summarizes the establishing method and research status of cats as an animal model of human diseases in ophthalmology, nervous system, tumor and other fields in recent years.

Objective To investigate the serum levels of angiopoietin-like protein-3(ANGPTL3)and nuclear factor of active T cells cytoplasmic 1(NFATc1)in patients with cerebral infarction,and their relationship with the severity and prognosis of the disease.Methods A total of 180 patients with cerebral infarction set as cere-bral infarction group who underwent treatment in our hospital from January 2021 to January 2023 were collected as research subjects.According to the NIHSS score,the patients were divided into mild group(n = 68),moderate group(n = 76),and severe group(n = 36),respectively.According to the mRS Score,they were divided into a good prognosis group(n = 117)and a poor prognosis group(n = 63).Another 180 healthy people were enrolled as the control group.The levels of serum ANGPTL3 and NFATc1 were compared among the groups.Multivariate logistic regression was adopted to analyze the influencing factors of prognosis in the patients with cerebral infarction.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum ANGPTL3 and NFATc1 on the prognosis of the patients with cerebral infarction.Results The serum levels of ANGPTL3 and NFATc1 in the cerebral infarction group were significantly higher than those in the control group(P<0.05).The levels of serum ANGPTL3 and NFATc1 were significantly increased in an ascending order across the mild,moder-ate,and severe groups(P<0.05).The volume of cerebral infarction,white blood cell count,ANGPTL3,and NFATc1 levels in the patients with poor prognosis were significantly higher than those in the patients with good prognosis(P<0.05).Regression analysis showed that cerebral infarction volume,white blood cell count,ANG-PTL3,and NFATc1 were the influencing factors of the prognosis of cerebral infarction patients(P<0.05).The levels of ANGPTL3 and NFATc1 together were more effective than they were alone in predicting the prognosis of the patients with cerebral infarction(Z combined detection-ANGPTL3 = 3.345,Z combined detection-NFATc1 = 2.898;P = 0.001,0.004).Conclusion The serum levels of ANGPTL3 and NFATc1 in patients with cerebral infarction are significantly increased,with the increase amplitude depending on the severity of the condition.ANGPTL3 and NFATc1,when combined,are more effective and valuable for predicting the prognosis of cerebral infarction patients.