1.Development of alpha-glucosidase inhibitor from medicinal herbs.
Fang JI ; Guochun XIAO ; Li DONG ; Zijiao MA ; Jingman NI
China Journal of Chinese Materia Medica 2010;35(12):1633-1640
Alpha-glucosidase inhibitor can reduce the postprandial hyperglycemia and have good effect on preventing and treating the diabetes and diabetic complication. Along with the application of acarbose which is a kind of alpha-glucosidase inhibitor, many research groups pay attention to the crude alpha-glucosidase inhibitor screened from the medicinal herbs in order to find new, safe, and effective medicine. The development of alpha-glucosidase inhibitor screened from the medicinal herbs and its evaluation in vivo and vitro as well as the varieties of the medicinal herbs that contain alpha-glucosidase inhibitor in recent 30 years were summarized in this paper.
Cell Line
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Drug Evaluation, Preclinical
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Enzyme Inhibitors
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isolation & purification
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pharmacology
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Glycoside Hydrolase Inhibitors
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Humans
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Plant Extracts
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isolation & purification
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pharmacology
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Plants, Medicinal
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chemistry