Spontaneous intracerebral hemorrhage is the most deadly type of stroke.Its 30-day mortality rate is nearly 40％.More than 30％ of patients with spontaneous intracerebral hemorrhage will have hematoma growth,which lead to poor outcomes.In addition to the classic predictors,some inaging signs also have important implications for identifying hematoma growth,such as swirl sign,blend sign,and black hole sign on nonenhanced CT scans,extravasation sign on contrast-enhanced CT scans,spot sign on CT angiography,leak sign revealed by the modified imaging method,as well as the spot sign on CT peffusion imaging.

Objective:To conduct a Meta-analysis to estimate the national incidence rate of fall injuries among primary and middle school students in China in recent five years and to provide evidence for reducing fall injuries among primary and secondary school students.Methods:Publications between 2016 and 2021 were extracted from CNKI, VIP, Wanfang Databases, and PubMed. Observational studies consisting on the incidence rate of fall injuries were included. Stata 17.0 software was used for Meta-analysis. Subgroup analyses were undertaken by gender, type of school, urban/rural areas, and case definition. Sensitivity analysis and publication bias were performed.Results:Thirty papers were included for Meta-analysis, with a total sample size of 431 054. The combined incidence rate of fall injuries was 8.03% for injured persons and 9.61% for times of injuries. For injured persons, the incidence of fall injury was higher in boys (7.50%) than in girls (6.20%) and rural areas (8.12%) than in urban areas (3.94%). The incidence rate from studies using the injury definition of 1996 (9.42%) was higher than that of 2004 (7.56%), while there was no significant difference in rates between students from different types of schools. For times of injuries, the incidence of fall injury in boys (10.89%) was higher than that in girls (9.26%), in primary school students (10.06%) was higher than that in middle school students (6.53%), in rural areas (15.06%) was higher than that in urban areas (12.52%). The incidence rate from studies using the injury definition of 1996 (8.86%) was higher than that using the definition of 2004 (7.59%). The Meta-analysis results were slightly changed after the literature with the lowest score in literature quality evaluation, and monitoring data analysis were deleted through sensitivity analysis.Conclusion:There are differences in the incidence of fall injuries among Chinese primary and secondary school students of different genders and between urban/rural areas.

To examine the association between serum copper concentration and the prevalence of hypertension in patients with knee osteoarthritis (OA).
 Methods: A total of 935 patients who were aged ≥40 years and underwent routine checkups from October 2013 to November 2014 at the Health Management Center of Xiangya Hospital, Central South University were included. They were diagnosed as knee OA by weight-bearing bilateral anteroposterior radiography. Serum copper concentration was measured using the chemiluminescence method. Blood pressure was measured by an electronic sphygmomanometer. The association between serum copper concentration and hypertension was evaluated by conducting multivariable adjusted logistic regression.
 Results: Compared with the lowest quintile, the multivariable-adjusted odds ratio (OR) and related 95% confidence interval (95% CI) of hypertension were 1.46 (95% CI 1.02 to 2.09, P for trend=0.035) and 1.47 (95% CI 0.77 to 2.78, P for trend=0.032) in the total population and female subgroup of the highestest quintile, respectively. There was no significant association between serum copper and hypertension in male subgroup among OA patients (OR=1.21, 95% CI 0.76 to 1.93, P for trend=0.354).
 Conclusion: The serum copper concentration was significantly associated with the prevalence of hypertension in total population and female subgroup, but may not in male subgroup among patients with knee OA.
Adult ; Copper ; Cross-Sectional Studies ; Female ; Humans ; Hypertension ; complications ; Male ; Odds Ratio ; Osteoarthritis, Knee ; complications ; Risk Factors

l-cysteine is an important sulfur-containing α-amino acid. It exhibits multiple physiological functions with diverse applications in pharmaceutical cosmetics and food industry. Here, a strategy of coordinated gene expression between carbon and sulfur modules in Escherichia coli was proposed and conducted for the production of l-cysteine. Initially, the titer of l-cysteine was improved to (0.38±0.02) g/L from zero by enhancing the biosynthesis of l-serine module (serA^f, serB and serC^Cg) and overexpression of CysB. Then, promotion of l-cysteine transporter, increased assimilation of sulfur, reduction or deletion of l-cysteine and l-serine degradation pathway and enhanced expression of cysE^f (encoding serine acetyltransferase) and cysB^St (encoding transcriptional dual regulator CysB) were achieved, resulting in an improved l-cysteine titer (3.82±0.01) g/L. Subsequently, expressions of cysM, nrdH, cysK and cysIJ genes that were involved in sulfur module were regulated synergistically with carbon module combined with utilization of sulfate and thiosulfate, resulting in a strain producing (4.17±0.07) g/L l-cysteine in flask shake and (11.94±0.1) g/L l-cysteine in 2 L bioreactor. Our results indicated that efficient biosynthesis of l-cysteine could be achieved by a proportional supply of sulfur and carbon in vivo. This study would facilitate the commercial bioproduction of l-cysteine.
Escherichia coli/metabolism* ; Cysteine/metabolism* ; Bioreactors ; Sulfur/metabolism* ; Serine/metabolism*