This paper summarized the recent progress of traditional Chinese medical treatments of cardiac neurosis,including acupuncture,Chinese traditional manipulation,massage,music therapy,psychic therapy,and herbal therapy.By conforming the curative effects of these treatments,we made discusses on the bright future of treating cardiac neurosis with traditional Chinese medical treatments.

With the deployment of electronic medical records systems, more and more routine clinical data are recorded electronically, which become a potential data source for new drug clinical trials. In this paper, we summarized the opportunities, challenges, obstacles and the latest development in this field.

Objective To explore the effect of fetal-type posterior cerebral artery (tPCA) on short-term outcomes and degrees of severity of acute large artery atherosclerosis (LAA) stroke.Methods A total of 689 patients with LAA stroke were consecutively collected from Nanjing Stroke Registry Program (August 2013 to December 2016) and stroke database of Yijishan Hospital of Wannan Medical College (January 2017 to December 2017) according to the strict inclusion criteria.Patients were divided into fPCA group (n=185) and non-fPCA group (n=504) according to the results of 3D-time of flight-MR angiography and maximum intensity projection.National Institutes of Health Stroke Scale (NIHSS) was used to assess the degrees of severity of stroke and mild stroke was defined as NIHSS scores ≤ 7.There-month modified Rankin scale (mRS) was used to evaluate the short-term stroke outcomes,and favorable functional outcome was defined as MRS score ≤ 1.The correlation between fPCA and LAA stroke was analyzed and the independent risk factors of LAA stroke were identified.Results There were no significant differences in gender,age,hypertension,diabetes,and hyperlipidemia between fPCA group and non-fPCA group (P＞0.05).Multivariable Logistic regression analysis showed that there was no significant association of fPCA with severity and short-term outcomes in patients with acute LAA stroke in either anterior or posterior circulation (P＞0.05);however,age was an independent risk factor for severe stroke and unfavorable stroke outcome (P＜0.05).Conclusion fPCA is a common variant of cerebral circulation,but has no significant influence in severity and short-term outcome of LAA stroke.

【Objective】 To evaluate the clinical characteristics and survival of patients with rare clear cell papillary renal cell carcinoma (ccpRCC). 【Methods】 Clinical data of ccpRCC cases treated during 2016 and 2019 were analyzed, clinical characteristics were described, and survival was analyzed using the Kaplan-Meier method. 【Results】 In the SEER database, 191 ccpRCC cases with complete clinical data and positive histology were retrieved, including 112 males (58.7%) and 79 females (41.3%), 136 Grade 1-2 (71.2%) cases and 19 Grade 3-4 (10.0%) cases, 174 stage T1 (91.1%) cases and 17 stage T2-3 (8.9%) cases. Distant metastasis (lung metastasis combined with lymph node involvement and major vein involvement) occurred in one case, and vein tumor thrombosis occurred in two patients. Surgery especially radical nephrectomy and partial nephrectomy was performed in 181 patients (94.8%). One patient died due to recurrence, and 4 due to other causes. The 12-month and 24-month survival were 98.5% and 97.4%, respectively. 【Conclusion】 Patients with ccpRCC have low clinical stage and histological grade, minimal tumor progression and distant metastasis, good prognosis and extremely low disease-specific mortality. Radical nephrectomy and partial nephrectomy have significant therapeutic effects.

AIM: To investigate the effect of low-dose aspirin on primary prevention of non-fatal myocardial and cerebral infarction in patients with type 2 diabetes mellitus. METHODS: From January 2015 to December 2016,40-90 years old patients with type 2 diabetes were treated in the Department of Endocrinology of Yijishan Hospital of Wannan Medical College for more than 2 times (the interval of hospitalization was more than 3 months) , we use the hospital's his system to search out-patient and in-patient files, patients were divided into aspirin group and non-aspirin group according to the use of low-dose aspirin within 1 year after the first visit, the basic data of the first visit were collected: name, sex, age, course of diabetes, systolic and diastolic blood pressure, patients were recorded for laboratory markers including fasting blood glucose, glycated hemoglobin, triglyceride, total cholesterol, Low-density lipoprotein, high-density lipoprotein, creatinine, and platelets, complications such as hypertension, coronary heart disease, atrial fibrillation, hyperlipidemia, diabetic nephropathy and arteriosclerosis were recorded. A Chi square test and a Cox proportional hazard model were used to compare baseline data and cerebrovascular disease after the first use of aspirin. RESULTS: Of the 4 176 patients, 2 137 were type 2 diabetes, 417 were eligible for admission, including 198 males, 219 females, 224 aspirin users and 193 non-users. There was no significant difference in the incidence of cerebral infarction between the aspirin group and the non-aspirin group (χ2=0.820, P=0.365). The incidence of non-fatal myocardial infarction was lower than that of the aspirin non-aspirin group (χ2=10.099, P=0.01) , the incidence of massive hemorrhage was significantly higher than that of aspirin-free group χ2=5.425, P=0.020) . In a subgroup analysis of aspirin use, patients younger than 60 years of age had a lower incidence of ischemic stroke (cerebral infarction) and a risk ratio of 0.428 (95%CI: 0.255-0.719, P=0.001) compared with patients older than 60 years of age, the incidence of cerebral infarction was higher in female patients with a risk ratio of 1.574 (95%CI: 1.018-2.434, P=0.041). CONCLUSION: In this study of patients with type 2 diabetes, low-dose aspirin reduced the incidence of nonfatal myocardial infarction but had no significant effect on the incidence of nonfatal ischemic stroke, and significantly increase the incidence of major bleeding events, we should reconsider the use of low-dose aspirin as a potential benefit of nonfatal cerebral infarction in patients with type 2 diabetes.