3.Study on the regulation of HPAT axis molecular network in patients with aging-physiologic shen-deficiency syndrome.
Chinese Journal of Integrated Traditional and Western Medicine 2004;24(9):841-843
Aging
;
genetics
;
physiology
;
Diagnosis, Differential
;
Humans
;
Hypothalamo-Hypophyseal System
;
physiology
;
Kidney
;
physiology
;
Medicine, Chinese Traditional
;
Neuroimmunomodulation
;
physiology
;
Pituitary-Adrenal System
;
physiology
;
Thymus Gland
;
physiology
;
Yang Deficiency
;
physiopathology
5.Longevity and cancer.
Chinese Journal of Integrated Traditional and Western Medicine 2003;23(4):302-303
Animals
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Apoptosis
;
genetics
;
Gene Expression Regulation
;
Humans
;
Longevity
;
genetics
;
Medicine, Chinese Traditional
;
Neoplasms
;
genetics
;
Rats
;
T-Lymphocytes
;
cytology
8.Correlation between level of TSH receptor antibody and activity of Graves ophthalmopathy after treatment with glucocorticoid
Hai-Bing JU ; Guang-Lin WANG ; Deng-Ming HU ; Zi-Zhen SHU ; Zi-Yin ZHU ; Fei-Fei SHEN ;
Chinese Journal of Endocrinology and Metabolism 2001;0(05):-
Fifty-six patients with Graves' ophthalmopathy(GO)were treated with antithyroid drug and oral prednisone for three months,TSH receptor antibody(TRAb)level was reduced,GO activity and severity of some patients were ameliorated but still positively associated with TRAb.It suggests that TRAb not only triggers off GO but also plays a possible role in the maintenance of the autoimmune process in GO.
9.Study on the regulative rule of reinforcing shen principle on sexual precocity and senescence at the molecular level.
Chinese Journal of Integrated Traditional and Western Medicine 2005;25(6):549-551
The imbalance of Shen-yin and Shen-yang is a common pathological basis of sexual precocity and senescence. Senescence can be regarded as physiological Shen-deficiency, which is mainly the deficiency of Shen-Yang, while the essence of sexual precocity is hyperactivity of Fire due to Yin-deficiency, and deficiency of Shen-Yin is the predominance in the imbalance. The process of growth, development, maturing and aging led by Shen-qi, is mainly involving the hypothalamus-pituitary-growth hormone axis and sexual gland axis. Early initiation of these two axes appears in sexual premature children, manifesting syndrome of Fire hyperactivity due to Yin-deficiency, while in senescence, the decline of the axes appears ahead of time and manifests syndrome of Yang qi consumption. It has been shown in experimental and clinical researches that significantly good effects could be obtained by applying Chinese recipe for warmly reinforcing Shen-Yang to postpone senescence and recipe for nourishing Yin and removing Fire to inhibit sexual precocity. It also been proved by determining syndrome and speculating the damaged site according to the effects of drug that the pathologic damage of sexual precocity and senescence is sited on the hypothalamus or higher center.
Aging
;
physiology
;
Diagnosis, Differential
;
Drugs, Chinese Herbal
;
therapeutic use
;
Female
;
Humans
;
Hypothalamo-Hypophyseal System
;
physiopathology
;
Hypothalamus
;
physiopathology
;
Kidney Diseases
;
drug therapy
;
physiopathology
;
Male
;
Medicine, Chinese Traditional
;
Phytotherapy
;
Puberty, Precocious
;
drug therapy
;
physiopathology
;
Yang Deficiency
;
drug therapy
;
Yin Deficiency
;
drug therapy
10.Regulatory effects of tuberculin on growth and apoptosis of liver cancer and lung cancer cell lines
zi-zhen, ZHANG ; yan-ying, SHEN ; xing-zhi, NI ; xiao-lu, YIN
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(08):-
Objective To investigate the regulatory effects of tuberculin on growth and apoptosis of liver cancer and lung cancer cell lines. Methods HePG2(liver cancer) and A549(lung cancer) cell lines were treated with TB supernatant(TB-SN) with different concentrations. Cell viability was detected by using LIVE/DEAD Viability/Cytotoxicity cell kits including specific fluorescence primer,and cell apoptosis was detected by Vybrant apoptosis assay. Results After treatment with 5% TB-SN for 5 d,cell apoptosis was significantly increased in HePG2 and A549 cell lines.Cell growth of HePG2 and A549 cell lines was inhibited after treatment with TB-SN. Conclusion Tuberculin can induce cell apoptosis and inhibit cell growth of liver cancer and lung cancer cell lines.