Objective To investigate the risk factors with placental abruption in patients with preeclampsia.Methods Retrospective analysis on medical documents of 219 patients treated in Peking University Third Hospital from Jan.1994 to Dec.2008.Patients were divided into 3 groups, including 52 cases with severe preeclampsia terminated following placental abruption, 130 cases only with severe preeclampsia and 37 cases with unexplained placental abruption without preeclampsia.One hundred and multivariate regression analysis were used to identify the risk factors for placental abruption in patients with preeclampsia.Results (1) When compared with those in control group, univariate analysis showed that gravidity, parity, history of preeclampsia, second and third trimester pregnancy loss, history of autoimmune disease, chronic hypertension disease, lack of regular antenatal care, fetal growth restriction (FGR) and raises of umbilical artery Doppler resistance were risk factors associated with placental abruption.Logistic regression analysis showed that lack of a regular antenatal care ( OR = 45.348, 95% CI: 17.096 - 120.288,P = 0.000 ), FGR ( OR = 27.087, 95% CI: 5.585 - 131.363, P = 0.000 ) and second/third trimester pregnancy loss( OR = 16.068, 95% CI: 1.698 - 152.029, P = 0.015 ) were independent risk factors with placental abruption.(2) When compared with those in preeclampsia patients without placental abruption,the history of preeclampsia ( OR = 3.715,95% CI: 1.096 - 12.596, P = 0.035 ) and lack of a regular antenatal care( OR = 2.509,95% CI:1.173 -5.370,P =0.018) were risk factors for placental abruption in preeclampsia.Conclusion Lack of regular antenatal care, FGR, history of preeclampsia and second/third trimester pregnancy loss were risk factors associated with placental abruption in patients with preeclampsia.

Objective: To understand the cognition status for risk factors and early symptoms of stroke via face to face questionnaire survey in 336 in-hospital patients with atrial ifbrillation (AF).
Methods: A face to face questionnaire survey was conducted by uniformly trained investigators in 336 AF patients who were admitted in our hospital more than 3 days from 2014-04-01 to 2014-10-01.
Results: There were 300/336 AF patients ifnished the questionnaire and among them 131 (43.7%) patients know that AF may increase the risk of stroke and 169 (56.3%) patients unknown or uncertain. There were 41.3%-79.3% patients having cognition for early symptoms of stroke and only 25.3% (76/300) patients may identify all 5 early signs of stroke.
Conclusion: In our research, AF patients had poor cognition for the risk and early signs of stroke. Medical professional should intensify the propaganda and education for stroke prevention.

Objective To investigate the sanitary status of rural drinking water in Hunyuan county, evaluate the effect of water improvement project to reduce fluoride in high fluoride areas, and to provide the basis for rural drinking water safety. Methods Between 2008 and 2010, in accordance with the "Rural water supply project implementation plan entral grant special funds for public health in Shanxi province", in Hunyuan county, 54 monitoring sites were selected, collected water samples. Water sample sensory properties, chemical, microbiological and other 19 indicators were tested. Forty project villages from 17 townships in Hunyuan county were selected to test water fluoride. June 2009 in Hunyuan county 3 high fluoride villages were chosen, all children aged 8 to 12 in the villages were examined of dental fluorosis (Dean method), and children's urine samples were collected to measured urinary fluoride. Water fluoride of the 3 villages was determined. Water and urinary fluoride were measured by fluoride ion-selective electrode method. Results In three years, a total of 188 samples were detected,with a pass rate of 35.1%(66/188), the main indicators that exceeded the standard were colony count(109 items), total coliforms (47 items), heat-resistant coliform bacteria(39 items) and fluoride(21 items). A total of 160 water samples in the 40 villages from the 17 townships were tested, the water fluoride excessive rate was 12.50%(20/160). A total of 522 children aged 8 to 12 were examined dental fluorosis, dental fluorosis rate was 7.66%(40/522), dental fluorosis index was 0.16; a total of 74 urinary fluoride of children aged 8 to 12 were measured, geometric mean was 1.17 mg/L, urinary fluoride range was 0.31 - 3.92 mg/L. Conclusions The drinking water improvement project in Hunyuan county rural areas has been successful, but sanitary conditions is poor. Water quality monitoring should be strengthened to ensure safe drinking water in the areas.

Objective To investigate any effects of carbamylated erythropoietin (CEPO) on the expression of LINGO-1,growth-associated protein-43 (GAP-43) and the infarcted volume after cerebral ischemia,so as to explore the effect of CEPO on neural regeneration after cerebral ischemia.Methods Forty-eight Sprague-Dawley rats were randomly divided into a sham operation group,an ischemia control group and a CEPO treatment group,each of 16.Middle cerebral artery occlusion (MCAO) was used to simulate focal cerebral ischemia in all except the rats in the sham operation group.Then the CEPO group was injected with 0.5 ml of CEPO,while the other two groups were given a 0.5 ml injection of normal saline daily for 7 days before they were sacrificed to prepare slices of brain tissue.Western blotting was used to detect the expression of LINGO-1 and activated caspase-3.Immunohistochemical staining was applied to observe the expression of GAP-43.The slices of brain tissue were stained with cresyl violet and the volume of infarction and edema were quantified with the Image J software.Results The average expression of LINGO1 in the sham operation group,the ischemia control group and the CEPO treatment group were (0.25±0.02),(1.22±0.06) and (0.66±0.05) respectively,with significant differences among the 3 groups.There was no expression of activated caspase-3 in the sham operation group.However,the expression of activated caspase-3 increased significantly (to 86.6±10.2)％ in the ischemia control group and increased significantly less (to 40.3±8.7)％ in the CEPO treatment group.The average positive expression of GAP-43 in the sham operation group,the ischemia control group and the CEPO treatment group were 0,(55.02± 1.62) and (72.11±3.23)/HP,respectively,with significant differences among them.Moreover,the average volumes of cerebral infarction and brain edema in the CEPO treatment group were significantly lower than those in the ischemia control group.Conclusions CEPO can inhibit the expression of LINGO-1 and activated caspase-3,promote the expression of GAP-43,reduce infarct volume and limit cerebral edema so as to promote neural regeneration after cerebral ischemia,at least in rats.

Estrogen has widespread biological actions. Besides sexual organs, estrogen plays an important role in cardiovascular system, central nervous sy s tem and bone tissue. However, the mechanisms of estrogen action are very complex and not fully understood. The actions of estrogen are not identical and even co mpletely different in some organs system. In this review, we will focus on the n ew development of molecular mechanisms of estrogen action.

Objective To study the effect of Tongfu Qingxia Decoction on the barrier function and inflammatory reaction regulation of intestinal mucosa in acute pancreatitis patients.Methods Patients selected were randomly divided into two groups.Routine treatment was conducted in control group,while Tongfu Qingxia Decoction was added in treatment group.Plasmic endotoxin,tumor necrosis factor-?(TNF-?)and interleukin-6(IL-6)were observed before and after treatment.Results After treatment,plasmic endotoxin,TNF-? and IL-6 decreased and interleukin-2 increased significantly in both groups(P

Acupuncture Therapy ; Aged, 80 and over ; Glossopharyngeal Nerve Diseases ; therapy ; Humans ; Male

Adolescent ; Child ; Electroencephalography ; Female ; Fructose ; analogs & derivatives ; therapeutic use ; Humans ; Male ; Migraine Disorders ; diagnostic imaging ; drug therapy ; physiopathology ; Ultrasonography, Doppler, Transcranial

Acupuncture Therapy ; Adult ; Humans ; Male ; Ossification, Heterotopic ; therapy ; Temporal Bone ; abnormalities

0.05).Compared with abnormality of rCBF in spastic left hemiplegia,there was significant difference between right and left lobes of cerebrum(P