This study aims at trying to establish a novel method of sterility test for injections based on biothermodynamics, in order to overcome the deficiencies of routine sterility tests such as long detecting cycle, low sensitivity and prone to misjudgments. A biothermodynamics method was adopted to rapidly detect the microorganism contamination of injections by monitoring the heat metabolism during the growth of microbe. The growth rate equal to or greater than zero and the heat power difference of P(i) and P(0) with three folds higher than the noise of baseline were chosen as indexes to study the heat change rule of microbe. In this way, the effectiveness of the new method to detect strains required by conventional sterility test or in injection samples was also investigated. Results showed that the Gram-positive bacteria, Gram-negative bacteria and fungi demanded by sterility testing methodology could be detected by biothermodynamics method within 10 hours, with the sensitivity lower than 100 CFU x mL(-1). Meanwhile, this method was successfully applied to the sterility test of Compound Yinchen injection (FFYC), Shuanghuanglian powder injection (SHL) and Compound Triamcinolone injection (TAND) which were sterilized with different degrees. Therefore, the biothermodynamics method, with advantages of fast detection and high sensitivity, could be a complementary solution for conventional sterility tests.

Objective? To discuss the application effects of Satir model team intervention model among patients after radicalcolorectal cancer surgery. Methods? From November 2017 to May 2018, 70 patients with colorectal cancer in Nanyang Hospital Affiliated to Zhengzhou University were selected by convenience sampling. All the research subjects were divided into intervention group and control group by random number table method, with 35 cases in each. The control group received routine nursing after operation, while the observation group received Satia model team nursing intervention on the basis of the control group. The Family Adaptability and Cohesion Evaluation Scale Ⅱ (FACES Ⅱ), the Social Avoidance and Distress Scale (SADS) and the Self-esteem Scale (SES) were selected to compare the effects. Results? The intimacy and adaptability scores of FACESⅡ in the observation group on the day after the intervention and one month after the intervention were significantly higher than those of the postoperative day and the control group, with statistical significances (P＜ 0.01). The SADS score of the observation group on the day after the intervention and one month after the intervention were significantly lower than those of the control group, with statistical significance (P ＜ 0.01). The SES score of the observation group on the day after the intervention and one month after the intervention were significantly higher than those of the control group, with statistical significance (P＜ 0.01). Conclusions? The Satia model team intervention is helpful to improve family relationship, self-esteem and social reintegration of patients with colorectal cancer after radical operation.