Statins may not only lower cholesterol concentration,reduce the incidence of heart diseases and relieve kidney damage,but also stimulate bone formation obviously,as suggested by a number of observation studies and animal researches.However,the exact mechanism of promoting bone formation has not been very clearly yet.Moreover,their adverse effects and their interaction with other drugs still need further clinical trials.In this review,on the basis of clinical data about the effects of hydroxymethylglutaryl-CoA(HMG-CoA)reductase inhibitors,we summarize current hypotheses on their mechanism and safety,in order to provide reference for the domestic bone reconstruction research.

MTA is rarely applied in the repair of root fractured section. A case of maxillary second premolar which fractured ten years ago had been connected with MTA in this article and the cone beam CT was used to evaluate the treatment effect.
Bicuspid ; Cone-Beam Computed Tomography ; Glutamates ; Guanine ; analogs & derivatives ; Humans ; Pemetrexed ; Tooth Root