Objective:The methods of hormone therapy prompt us to renewedly handle the perimenopausal dysfunctional uterine bleeding (DUB) and postmenopausal vaginal bleeding,search dangerous factors and optimize therapeutic schemes in order to reduce non-essential diagnostic curettage. Methods:45 perimenopausal women and 182 menopausal ones were choosed in our research and the following each index including the age of onset,body mass index,the course of diseases,excessive mentses,hypertension,diabetes, hormone replacement therapy,postoperative application of breast cancer,hypothyroidism,polycystic ovary syndrome or endometrial thickness was set as a variable to sdtudy the relationship between each variable and endometrial abnormity using Logistic regression analysis. Results:According to the Logistic regression analysis,there was a relevance between endometrial thickness and endometrial abnormity(endometrial hyperplasia & endometrial cancer)when the endometrial thickness was equal to or more than 7 mm during the perimenopause period (P=0.02),and so it was with the menopausal period when the endometrial thickness was equal to or more than 9 mm (P