Objective In this study we reported our experiences for patients with unresectable advanced hilar cholangiocarcinoma by intracavitary irradiation therapy and discussed some problemsin practice.Method 15 cases with unresectable advanced hilar cholangiocarcinoma were treated with laparotomy and operative dilatation of malignant stenosis and cathetenizing and then followed by intracavitary irradiation therapy.Result 15 cases treated by intracavitary irradiation therapy diedfrom liver function failure with biliary cirrhosis 3～18 months (average 8 months) later. None of the case died from cancer dissemination. Conclusion The patients with advanced holar cholangiocarcinoma could well tolerant of the intracavitary irradiation therapy, but they deteriolated from biliary cirrhosis about 8 months later,not from tumor dissemination.