Objective To explore the effect of specific nursing on quality of life of the parents of children with mental retardation (MR). Methods 160 parents of children with MR and 160 parents of normal children were evaluated with WHO Quality Of Life-BREF (WHO-QOL-BREF). The children with MR were divided into observation group (n=80) and control group (n=80). The control group received the traditional nursing care, and the observation group accepted specific nursing care. The scores of WHOQOLBREF were compared. Results The score of WHOQOL-BREF was lower in the MR group than in the normal group (P<0.01). The score decreased with the aggravation of MR (P<0.001). The score of WHOQOL-BREF was higher in the observation group than in the control group (P<0.01). Conclusion Specific nursing should be given to the parents of children with MR, which can promote their quality of life.

Objective To apply the Comprehensive Function Assessment for Disabled Children in family care for children with cerebral palsy. Methods From May, 2014 to May, 2015, 120 cerebral palsy children were equally divided into control group and observation group. The control group accepted routine rehabilitation, and the observation group accepted targeted family rehabilitation program based on the evaluation of Comprehensive Function Assessment for Disabled Children. They were assessed with Comprehensive Function Assessment for Disabled Children before and three months after rehabilitation. Results The scores of cognitive function, language function, exercise abil-ity, self-care movement and social adaptation ability improved in both groups after rehabilitation (t>2.498, P<0.05), and improved more in the observation group than in the control group (t>2.062, P<0.05). Conclusion The application of Comprehensive Function Assessment for Disabled Children may help to plan a targeted rehabilitation nursing program for the nurses and the parents, that benefits the rehabilitation for children with cerebral palsy.

Circular RNA(circRNA)is a new type of non-coding RNA molecule with covalent closed-loop structure.CircRNA is involved in various processes of tumor development,such as tumor angiogenesis,epithe-lial-mesenchymal transformation(EMT),drug resistance,invasion,etc.CircRNA could enter the blood circu-lation in the form of exosomes and microvesicles,and is not easily degraded by nuclease,and could exist stably in the blood circulation.The progression of gastrointestinal tumors is closely related to the expression level of circRNA in peripheral blood,and peripheral blood circRNA may be a potential novel non-invasive diagnostic marker for gastrointestinal tumors.This article reviews the research progress of circRNA in the diagnosis of gastrointestinal tumors,focusing on the clinical application value of peripheral blood circRNA in the diagnosis of gastrointestinal tumors.