Objective To compare the effect of nasotracheal intubation between Airtraq video laryngoscope and Macintosh laryngoscope in patients with obstructive sleep apnea and hyperpnoea syndrome(OSAHS). Methods A total of 60 patients with OSAHS receiving nasotracheal intubation were randomly divided into two groups: the group M was intubated with Macintosh laryngoscope and the group A was intubated with Airtraq video laryngoscope.The blood pressure and heart rate were recorded before induction(T0),before intubation(T1),immediately after intubation(T2),first minute(T3)and fifth minute(T4)after intubation. The intubation time,Cormach-Lehane scale,external laryngeal press,use of magil forceps and the incidence of blood on laryngoscope were recorded. Results The systolic pressure and heart rate at T 2,T3and T4were significantly higher than T1in the group M(P<0.05),but no significant changes were found among T 2,T3and T4in the group A(P>0.05).The systolic pressure was significantly different between the two groups at T 2and T3(P<0.05).The heart rate was significantly different between the two groups at T 2,T3 and T4(P<0.05).The diastolic pressure was not significantly different between the two groups(P >0.05).The laryngoscope exposure scale in the group A was significantly superior to the group M(Z=-4.935,P=0.000).The intubation time in the group A(30.4 ±9.0)s was significantly less than that in the group M[(42.3 ±16.5)s, t =-3.468, P =0.000]. Conclusion Nasotracheal intubation with Airtraq video laryngoscope has less influence on hemodynamics,shorter intubation time and easier performance as compared with Macintosh laryngoscope in patients with OSAHS.