Sepsis is a common critical illness in pediatric intensive care unit,and its prognosis assessment has always been a challenge in pediatric critical care researches.In 2016,Sepsis 3.0 defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.The diagnostic criteria were revised to include a sequential organ failure assessment (SOFA) score increase ≥2 points from baseline in infected/suspected infected patients.However,aforementioned guidelines primarily focus on adults.Considering the unique physiological characteristics of children,the pediatric sequential organ failure assessment (pSOFA) was developed.Currently,the definition of pediatric sepsis has not been updated to include organ dysfunction,and the use of the pSOFA score is not widespread.This review introduced the background,content,and application of the pSOFA score,and compared it with other scoring systems to determine its advantages and application range in prognosis assessment.Finally,it summarized the value of pSOFA score in the prognosis assessment of pediatric sepsis,aiming to provide references for clinical applications.