Stress,as an adaptive response of the organism to internal and external environmental stimuli,may have detrimental effects on health when excessively or continuously activated,particularly on contributing the occurrence and progression of cardiovascular diseases.Therefore,this paper comprehensively reviews the relationship between stress and cardiovascular diseases from four aspects:epidemiology,pathophysiological mechanisms,stress-related cardiovascular diseases and advances in the treatment,aiming to provide references for prevention,early diagnosis and effective intervention of cardiovascular diseases in clinical practice.