Objective To evaluate the upper thoracic block on the consumed oxygen and ischemia dergoing lobectomy were randomized to receive either combined general-epidural anesthesia(GEA group,n=25)or general anesthesia(GA group,n=25).To observe systolic pressure(SBP),heart rate(HR),ST section and T wave before anesthesia(T1),after epidural infusion 20 minutes(T2),intubated the trachea(T3),at the end of operation(T4),drew the trachea(T5),after drew the trachea 30minutes(T6).Results SBP,HR,RPP were significantly increased in GA groupas compared with those in GEA group at L3,L5,T6(P＜0.05),The change of ST section and T wave were significantly improved in GEA group as compared with those in GA group at T2,B3,T4,T5,T6(P＜0.05).Conclusion The influence of the upper thoracic block can decrease the consumed oxygen and ischemia, improve the myocardial ischemia in the coronary disease patient undergoing lobectomy, to reduce the complication of the coronary disease patient in the perioperative.