OBJECTIVE:To discuss clinical pharmacists' role in clinical drug treatment. METHODS: Case study was performed retrospectively on clinical pharmacists' involving in clinical drug treatment. RESULTS & CONCLUSION: Hospital pharmacists' participating in drug treatment had achieved remarkable outcome. Clinical pharmacists have to cooperate with medical staff in clinical drug treatment so as to bring their due role into full play.

China ; epidemiology ; Hepatitis, Viral, Human ; epidemiology ; Humans

Objective To establish an equation of oxygen consumption in obese children and adolescents by multilevel linear model analytical method. Methods Sixty obese children and adolescents aged 11-16 years were randomly divided into the formula group(n=40) and back substitution verification group(n=20), with equal male and female. Subjects in formula group started exercise in the speed of 2km/h, increased lKm/h every 2.5 minutes till 8km/h, without gradient in treadmill and 80% HRmax was set as standard of exercise termination. Gaseous metabolism parameter and heart rate were measured for the set up of multiple linear regression equation of oxygen consumption. Back substitution verification was also made. Results Males' R~2 was 0.795 and females' R~2 was 0.75 in regression equation; oxygen consumption had a linear relationship (P0.001) with HR and LBM; The significance of variation coefficient and constants were obvious. The regression equation were set up as male:oxygen consumption(ml/min)=20.098xheart rate(bmp)+25.160×LBM(kg)-2935.835 and female: oxygen consumption(ml/min)=19.863xheart rate(bmp)+26.551×LBM(kg)-2675.676. The predictive value of oxygen consumption of the average relative error was 6.84%～8.72% in male, and 6.53%～8.23% in female. Conclusion The multiple regression equation of oxygen consumption with heart rate and body weight as independent variables might be applied in the calculation of the oxygen consumption of physical activity in obese children and adolescents.

BACKGROUND:The current studies concerning the effect of obesity on children are limited to metabolic physiology, and there is little evidence available on skeletal muscle and motor ability.
OBJECTIVE:To compare isokinetic knee muscle strength between obese children and normal children, and analyze the causes of physical performance decline in obese children.
METHODS:A total of 56 children were recruited in this study, including 28 obese children and 28 normal children. The isokinetic muscle strength was tested by CON-TREX. The gaits were tested by VICON. The statistical analysis of al the differences between obese children and normal children were measured using SPSS 19.0 software.
RESULTS AND CONCLUSION:At the same gait speed, obese children had higher absolute peak torque and average power than normal children (P<0.05), but relative peak torque and relative average power showed no significant difference compared with normal children (P>0.05) except extensor group at 60(°)/s was significantly lower than normal children. At the same gait speed, the torque and power of extensor group were significantly higher than that of flexor group in the two groups (P<0.05);he obese children showed significant differences in the absolute peak torque and absolute average power compared with relative peak torque and relative average power of flexor group at 120(°)/s (P<0.05). In the two groups, the extensor exhibited higher torque in high speed, while the high flexor torque was found in low speed. Normal children had faster cadence and walking speed, significantly smal er step width and shorter stride time than obese children (P<0.05). Obese children have smal er relative strength and higher absolute strength than normal children;in addition, the low cadence and walking speed are found in obese children. These factors contribute to weak limb strength and insufficient motor ability.

AIM: To improve the quality standard of Compound Xilingjiedu Tablets(Flos Lonicerae, Fructus Forsythiae, etc.). METHODS: Fructus Forsythiae、Fructus Arctii and Radix Glycyrrhizae were identified by TLC. The chlorogenic acid content of Flos Lonicerae was determined by HPLC. RESULTS: TLC spot developed were fairly clear. The method of content determination of chlorogenic acid by HPLC was practicable. CONCLUSION: The method is able to control the quality of products effectively.

BACKGROUND:SenseWear Pro Armband (SWA) is a monitoring device of physical activity energy consumption which consists of many kinds of motion sensors, and it has been widely used in the study of physical activity energy consumption in recent years. OBJECTIVE:To summarize the SWA accuracy, software version, time of wear as wel as its application in different populations and at different physical activity levels, for the purpose of providing some practical reference in the future usage of SWA. METHODS:A computer-based search of CNKI (ful-text database), PubMed and Web of Science databases was done for relevant articles published before January 2015 using the keywords of “physical activity, sensewear pro armband, energy expenditure, review” in Chinese and English, respectively. Articles published in core journals or SCI database were preferred. RESULTS AND CONCLUSION:Double labeled water method and indirect measurement method serve as standard criteria, and the relevant study shows that SWA has higher accuracy and can effectively evaluate the daily physical activity energy consumption. But under the special circumstances, there are some differences, such as different people and different exercise intensities. Meanwhile, to determine the appropriate wearing time and software version for data statistics are also one of the factors influencing the accuracy of the final result. SWA can accurately predict physical activity energy consumption, but for different populations and exercise intensities, it is necessary to improve the further calculation formula of SWA.

OBJECTIVE: To study the situation and the related factors of ADR occurred in our hospital and to provide references for rational use of drug. METHODS: A total of 246 ADR case reports collected in our hospital from Nov. 2007 to Oct. 2008 were analyzed statistically. RESULTS: Of the 246 ADR cases, 120 kinds of drugs were involved. 64.63% of ADR were induced by intravenous drip infusion; 42.28% were antimicrobial,13.01% were drugs for central nervous system, 10.57% were for circulation system, 7.32% were TCM preparation; ADR-inducing TCM injection accounted for 50.00% in TCM preparations. The main clinical manifestation represented as lesion of skin and its appendants (51.63%). 11 severe cases accounted for 4.47% and 1 new cases only 0.41%. CONCLUSION: ADR may be caused by many factors. The most attention should be paid to monitoring ADR in the clinic so as reduce or avoid occurrence of ADR.

OBJECTIVE:To prepare Qingyang tea bag and establish the standard of quality control.METHODS:The Flos Lonicera and Radix Glycyrrhize were identified by TLC.The content of chlorogenic acid,the main active component in the tea derived from Flos Lonicera,was determined by TLCs.RESULTS:Linearity was found in the range from1.2?g～4.8?g of chlorogenic acid,r=0.9993;the average recovery was99.50%and RSD=2.39%.CONCLUSION:The method was found to be simple,precise and may be used for the quality control of the preparation.

OBJECTIVE:To promote the computerized management of drug database.METHODS:The function of drug database software development system(SDS)developed by the co-efforts of pharmacy department and information center in our hospital was introduced.RESULTS:With hospital information system,the software can conduct statistics and queries of patients’drug database information at any time.CONCLUSION:The computerized management of drug database can provide prompt and efficient data support for rational drug administration and which is in the benefit of the development of clinical pharmacy work.

Objective To expolore the changes of coagulation index in newborns of different age and its clinical significance. Methods We studied 129 newborn infants without complication admitted to the neonatal department in an all-around hospital in Gnangzhou from January to December in 2005. These neonates were divided into two groups, including 63 cases of full-term infants and 66 cases of premature infants. Prothrombin time (PT), activated partial prothrombin time (APTT), Fibrinogen (Fg), thrombin time (TT), D-dimer (D-D) of these newborn infants were assayed on the first day, the third day and the tenth day. Results In the postnatal three periods of time, there was no difference in PT and D-dimer between two groups(P >0.05), but APTT and TT in premature infants were higher than that in full-term infants( P < 0.05), and Fg in premature infants were lower than that of full-term irfants(P<0.05). PT,APTT, TT,Ddimer were in decrease tendency and Fg increased as age increased( P < 0.05 ). Conclusion Geststional age and age had effect on coagulation index in newborn infants, and both can provide clinical references to clinical diagnosis and therapy.