Mucin antigen 4 (MUC4) is a molecular marker for some malignant tumors for early tumor diagnosis, prognosis and targeted therapy. It provides a new research direction in tumor diagnosis and treatment that will have a wide application prospect. In recent years, there has been a large number of research reports on the basic and clini-a wide application prospect. In recent years, there has been a large number of research reports on the basic and clinical studies about MUC4, but the molecular imaging study about MUC4 is seldom reported. In this paper the recentcal studies about MUC4, but the molecular imaging study about MUC4 is seldom reported. In this paper the recent research about MUC4 on basic and clinical studies is briefly reviewed, and it is expected to promote the development of tumor molecular imaging.
Biomarkers, Tumor ; metabolism ; Early Diagnosis ; Humans ; Mucin-4 ; metabolism ; Neoplasms ; metabolism ; Prognosis

Objective Analysis and assessment the level of psychological health of army talented medical people. Method Basing on tri-blindness paradigm, 71 talented medical people and controls from different military medical institutions or hospitals were tested with Psychological Health Inventory (PHI). Results There was significant differences between excellent workers and its controls in psychopathic deviate, anxiety, unrealistic, and excellent workers was lower than controls; there was, however, no significant difference in somatization, hypomania, hypochondria, depression. Conclusion Some certain psychological health facts play a important role in those medical talented people' career development and achievement.

Objective To investigate the involvement of estrogen receptor(ER)? in the proliferation of ovarian clear cell adenocarcinoma by restoring ER? expression in a cell line ES-2.Methods A plasmid with full length ER? cDNA,pRSV-ER? and its negative vector control pRSV were introduced into ES-2.The cells transfected were named according to the plasmids:ES-pRSV,ES-pRSV-ER?.RT-PCR and western blot were used to detect the expression of ER? in ES-2,ES-pRSV and ES-pRSV-ER? cells.The growth activities of cells in vitro were detected by methyl thiazolyl tetrazolium(MTT)assay,and in vivo growth in nude mice was also observed.Flow cytometry was performed to show the change of cell cycles. Results The ES-pRSV-ER? cells were identified with ER? mRNA and protein expression.The growth activities of ES-pRSV-ER? were inhibited in vitro.In MTT analysis,the values of ES-2,ES-pRSV,and ES- pRSV-ER? cells were 0.78?0.05,0.81?0.06,and 0.53?0.07(the third was lower compared with the former two,P

Objective To evaluate the clinical value of ulinastatin on the treatment of systemic inflammatory response syndrome in severe acute panereatitis. Method Eighty-four patients with severe a-cute pancreatitis were randomly divided into two groups. In the treatment group (42 cases),on the base of routine treatment, ulinastatin was administered intravenously for seven days after hospitalization, while in the control group only routine treatment was given (42 cases) to. Inflammatory factors in serum, the change of liver function and renal function were measured in two groups before and after the treatment, and the clinical efficacy were observed. Results There was significant difference, in the serum level of tumor necrosis factor-α, interleukin-1, interleukin-6, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen and creatinine on the 7th day between two groups (P < 0.05 or < 0.01 ) ,there were significant differences in the incidence of complications, hospitalization time, incidence of multi-organ failure between two groups [14.3%(6/42) vs 38.1%(16/42), (29.4 ± 1.5)d vs (34.4 ± 1.8)d, 28.6%(12/42) vs 47.6%(20/42), P<0.01 or <0.05 ]. Conclusions Ulinastatin can suppress the secretion and release of some inflammatory factors, protect the important viscera functions and reduce the incidence of complications, and it has favorable clinical efficacy.

Objective To examine the efficacy of applying clinical pathway (CP) teaching model in orthopedics clinical teaching.Methods Totally 64 medical undergraduates were randomized into 2 groups.The traditional teaching method and CP model were separately preformed on them.Their scores of theoretical,manipulation and case analysis exams at the end of internship were compared.Meanwhile the questionnaire of satisfaction degree also was conducted.Results Scores of exams and satisfaction degree were better in CP group than in classical group (P ＜ 0.05).Conclusions The novel CP model can promote the standardization and systematization of clinical teaching in orthopedics.It is conducive to evaluating teaching effect and performing teaching reform.Meanwhile,it is in accordance with the problem-based learning and can improve clinical teaching effect and satisfaction degree.

Objective To evaluate imaging diagnosis, differential diagnosis, surgery and interventional therapy of hepatic angiomyolipoma associated with tuberous sclerosis.Methods Clinical features, imaging appearances and interventional therapy for 2 cases of HAML in TS were retrospectrively analyzed. Results The features of HAML in TS are as following:(1) Two cases were female with no history of hepatitis and hepatocirrhosis, liver function test and alpha feto protein were normal. (2) the tumor was shown as a multiple hyperechoic mass with sharp margin on ultrasonography; well defined, fat density and intensity mass on computerized tomography (CT); hypervascular mass with early drainage of hepatic vein and tumor staining on angiography. (3) One case underwent interventional therapy. After 42 month follow up, the tumor was found to be diminished in size. Another case was under monitored with only the enucleating of left renal mass. The hepatic tumor showed no change after 10 months.Conclusions The imaging appearances of HAML in TS are relatively characteristic. Superselective arterial embolization is an effective treatment for HAML in TS.

Objective To explore the cytological mechanism of bi ological reaction of prosthetic loosening mediated by wear particles from joint prosthesis. Methods Three special particles of UHMWPE, Ti- 6Al-4V and Co-Cr-Mo with the same average size of 2.5 ?m were injected respe ctively into rabbit knee joint to induce synovitis, in which the changes of syno vial cells and its cytoplasm as well as ultrastructure were observed by transmis sion electron microscopy. Results Three kinds of particles mainly induced type A synovial cell reaction with proliferation of subsynovial h istocytes. Wear particles and lysosomes existed in the cytoplasms of the synovia l cells and histocytes. Co-Cr-Mo particles could also accelerate infiltrating reaction of regional cytoplasms. Conclusions The biological effect of wear particles inducing prosthetic loosening is mainly non-immunolog ic inflammatory reaction. Certain immunologic factors may involve in biological reaction induced by Co-Cr-Mo wear particles.

Objective To appraise the clinical therapeutic effects of lamivudine in patients with chronic hepatitis B, and the recurrence of the disease after withdrawal of the drug. Method 122 patients with chronic hepatitis B treated with lamivudine were followed-up for over half a year after withdrawal. Result It was shown that, among the 9 cases in immunological tolerance stage and received lamivudine treatment, 4 showed effective result and ineffective in 5. All the 4 patients with effective result recurred within 6 months after lamivudine withdrawal. Among the 113 patients in non-immunological tolerance, 13 showed notable effective result (11.50%), 90 effective (79.65%) and 10 showed ineffective result (8.85%), respectively. The disease in 11 patients showing effective result recurred during the treatment. The rate of recurrence was 53.85% and 87.34% respectively in patients with notable effective and effective results. The level of ALT before lamivudine treatment showed no significant difference between the patients with abrupt and gradual withdrawal of lamivudine treatment, but it was significantly different after lamivudine withdrawal. The rate of recurrence showed no significant difference between patients with abrupt and gradual withdrawal of the drug. Conclusion The therapeutic effect of lamivudine is poor in immunological tolerant patients. Patients with chronic hepatitis B are likely to recur after lamivudine withdrawal. Lamivudine should be given for a long-term to inhibit persistent HBVDNA replication.

According to the causes and pathogenesis of lung cancer in traditional medicine,the principle of syndrome differentiation and treatment,the research achievements of modern medicine,we discuss the idea and method of syndrome differentiation and treatment of lung cancer by integrated traditional and western medicine.We believe the treatment of lung cancer can be taken from several aspects:strengthening body essence and eliminating pathogen;individualized treatment according to the principle of syndrome differentiation and treatment;combining differential symptoms and diagnosis of diseases according to achievements of lung cancer treatment in traditional medicine;choosing suitable treatment by integrated traditional and western medicine considering the different stage of lung cancer.

Objective To explore the way of soft tissue balance in total knee arthroplasty for patient with flexion contracture. Methods A relevant protocol of soft tissue balance was designed and used in 33 TKA cases with knee flexion contracture of at least 20? (from 20? to 60? ). Tight medial collateral ligament or lateral collateral ligament was released firstly, followed by the release of posterior capsule. Osteotomy or a second osteotomy at tibial or femoral side were performed at final step. Results Twenty cases (60.6%) whose flexion deformities could be corrected solely by soft tissue release, the rest 13 (