Objective:We had analyzed the attitude of science researchers in a university to promote the development of science cause in the university. Method:We had made a prevalence survey through a questionnaire. Results:Some researchers join in science cause to acquire some profits,they often change their research orientation and they aren’t willing to cooperate with each other. Conclusion:We must initiate a kind of spirit of which advantageous to collaborate,insisting,struggling and seeking the truth of science.

For the particularity of obstetrics and gynecology disease and conventional idea of the people,clinical education of obstetrics and gynecology is very difficult.How to increase the clinical education quality of obstetrics and gynecology and how to increase the clinical'ability of medical students have become an important problem in teaching obstetrics and gynecology.In this article,we have discussed the problems and countermeasures in the teaching of obstetrics and gynecology.

Objective:To find a good culture medium for embryo development in-vitro.Methods:D4 mouse embryo was cultured with carcinoma of kidney GRC-1 growth fluid and FD+20% fetal calf serum respectively in-vitro and the rate of zona-hatching,attachment and trophoblast outgrowth were compared respectively.Results:The rate of zona-hatching,attachment and trophoblast outgrowth with GRC-1 were 89.68%,86.51 %和84.92%,respectively.These were significantly higher than those of the control group ( P

Anticoagulants ; therapeutic use ; Atrial Fibrillation ; complications ; Humans ; Thromboembolism ; etiology ; prevention & control

BACKGROUND: Resistin decreases insulin's action. Therefore might be a key molecule in the pathogenesis of type 2 diabetes mellitus in obese subjects.OBJECTIVE: To investigate the correlation of resistin gone expression and insulin sensitivity index (ISI) in type 2 diabetic rat models, and to explore the effect of rosiglitazone on resistin gone expression in a rat diabetic model.DESIGN: Randomized controlled animal study.SETTING: Department of Geratology, the First Affiliated Hospital of Zbengzhou University.MATERIALS: Thirty 2-month-old healthy female Wistar rats were provided by Animal Center of Tongji Medical College,Huazhong University of Science and Technology. Common diets were provided by Animal Center of Tongji Medical College, Huazhong University of Science and Technology, and the gross calorific value was 14.88 J/g (mass fraction: 0.2protein, 0.61 carbohydrate, 0.17 fat); furthermore, high-fat diets were mixed with common diets, saccharobiose, rendered lard, egg, and mild powder, and the gross calorific value was 20.083 J/g (mass fraction: 0.09 protein, 0.51 carbohydrate, 0.38fat). Resistin and β -actin were synthesized in Beijing Salbaisheng Company.METHODS: This study was performed in the First Affiliated Hospital of Zhengzhou University from October 2006 to October 2007. The experimental for animal manipulation conforms to criteria of the university's ethnic committee. Two weeks after adaptability, rats were randomly divided into normal chew group (n=8) and high-fat diet group (n=22). Rats in the high-fat diet group underwent vena caudalis injection with streptozotoein (25 mg/kg), and two days later they were continued fed with high-fat diet. For normal chew group rats were injected with sodium citrate-citrate buffer solution (1 mL/kg) and continued normal chew. After 12 weeks, 15 rats in the high-fat diet group were hyperglycemic and were randomly divided into rosiglitazone (n=8) and high-fat diet diabetic group (n=7). Rats were lavaged with rosiglitazone (2 mg/kg/d) in the rosiglitazone group and with distilled water (8 mL/kg/d) in high-fat diet diabetic group; for normal chew group rats were lavaged with the same volume of distilled water. Rats were studied for four successive weeks.MAIN OUTCOME MEASURES: Fasting serum glucose was measured with glucose oxidase method; insulin by magnetic separation enzyme linked immunosorbent assay; triglyceride and total cholesterol levels by enzymic enzymatic method; ISI was calculated as [1/(fasting serum glucose × fasting insulin)]; resistin mRNA expression in greater omental adipose tissue was examined by RT-PCR; correlation between resistin gene and ISI analyzed by Spearman correlation and multivariate stepwise regression.RESULTS: Fifteen high-fat diet rats and eight normal chew rats were included in the final analysis. Resistin gene expression in the greater omental adipose tissue (A value) was 0.27±0.031 in the high-fat diet diabetic group (0.15±0.018) in the normal chew group, and (0.20±0.024) in rosiglitazone group (P < 0.01). Spearman correlation analysis and multiple stepwise regression analysis showed that resistin gene expression was positively correlated with fasting serum glucose (r=0.271, P < 0.01), fasting insulin (r=0.283, P < 0.01), and ISI (r =0.323, P < 0.01), apparent effects of resistin gene expression on ISI was 0.081.CONCLUSION: High-fat diet and diabetes increases resistin gene expression and rosiglitazone ameliorate its expression.The expression of resistin is correlated with ISI.

Objective To observe the clinical curative effect of treating reflux esophagitis of spleen qi deficiency syndrome byHezhong-Jianpi decoction.Methods 90 patients in October 2012 to March 2014 in the standard of traditional Chinese medicine hospital of Shanghal were randomly divided into a western medicine group (omeprazole), a Chinese medicine group (Hezhong-Jianpi decoction), and a Chinese and western medicine group (Hezhong-Jianpi decoction + omeprazole), 30 cases in each group. All groups were treated for successive 8 weeks and the changes of the symptoms of integral and esophageal mucosa under gastroscope change situation were observed, and the clinical efficacy was evaluated. Results After the treatment, the esophagus gastroscope integral of the western medicine group, the Chinese medicine group and the Chinese and western medicine group were all significantly improved than those before the treatment group (Z value was respectively -4.351, -4.300, -5.143,P<0.01). Total effective rate was 83.3% (25/30) in the western medicine group, 86.7% (26/30) in the Chinese medicine group, and 90.0% (27/30) in the Chinese and western medicine group, the difference among the three groups was statistically significant (χ2=6.800,P=0.030). The difference of symptoms integral of the western medicine, Chinese medicine, and Chinese and western medicine group was statistically significant (Z values are -5.482, -5.991, -6.120, respectively, P<0.01).Comparison between two groups after treatment showed only Chinese traditional medicine group and the Chinese and western medicine group was statistically significant (Z=-2.113,P=0.040). After the treatment, symptoms as heartburn (Z value -3.390, -3.882, -3.666, respectively), the acid regurgitation (Z value -4.850, -5.004, -5.722, respectively), the food regurgitation (Z value -2.791, -3.422, -2.854, respectively) in the three groups improved significantly than those before the treatment (P<0.01); The retrosternal paln improved significantly in the Chinese and western medicine group after the treatment (Z=-0.873,P=0.380). The pharyngeal foreign body sensation or paln symptoms (Z value were -2.382 and -2.724, respectively), belching symptoms (Z value were -5.074 and -5.061, respectively) in the Chinese traditional medicine group and the Chinese and western medicine group significantly improved after the treatment(P<0.05); The abdominal distension (Z value were 2.772 and -2.032, respectively), the abdominal paln (Z value were 2.26 and 2.02, respectively) in the western medicine group and the Chinese and western medicine group were significantly improved (P<0.05). Conclusion Hezhong-Jianpi decoction can significantly improve the clinical symptoms of reflux esophagitis of spleen qi deficiency, and the curative effect is similar to omeprazole. It has advantage for relieving belch and retrosternal paln. The combined therapy was more effective than eitherHezhong-Jianpi or omeprazole, but no difference was showed in the improvement of esophageal gastroscopy.

Invasive fungal infection is an important cause of mortality and morbidity in preterm infants.Extremely preterm and extremely low birth weight infants are at highest risk because of the intensive and invasive nature of the care that these infants receive.How to prevent and treat the invasive fungal infection in preterm infants has become a new hot spot in the neonatologists.This review focused the progress on treatment and prevention of invasive fungal infections in preterm infants.

Fetuin A is a kind of glycoprotein that is synthesized and secreted by the liver.It is a natural inhibitor of insulin receptor tyrosine kinase,which is involved in the formation of insulin resistance.It is closely related to the nonalcoholic fatty liver disease.This paper reviews the related research on effect of fetuin A in the occurrence and development of non-alcoholic fatty liver disease.

Mitochondrial fatty acids ?-oxidation is a repetitive process of four steps which provides the major source of energy for heart, liver and skeletal muscle. Several enzymes are involved in this spiral cycle. The medium-chain acyl-CoA dehydrogenase ( MCAD) , the short-chain acyl-CoA dehydrogenase (SCAD) , the long-chain 3-hydroxy acyl-CoA dehydrogenase (LCHAD) and the carnitine-palmitoyl-CoA transferase Ⅱ ( CPT Ⅱ ) deficiency have been recognized as the most common inborn errors of metabolism and frequently reported in their association with sudden infant death ( SID) . The prevalent mutations in these genes need further investigation in different populations.

Objective To compare the effects of Valsartan on blood ressure(BP)of patients with mild to moderate essential hypertension(EH).Method 64 patients with EH were randomly divided into 2 groups:Valsartan group(Enalapril 10 mg bid n=32).Treatment lasted for 8 weeks.Result Valsartan and Enalapril significantly reduce BP compared with that bdfore treatment(P< 0.05),effective rate and magnitude of decreasing BP were no significantly different between two groups(effective rate of Valsartan group was 78.1％ vs 70.0％ in Enalapril group(P>0.05).Conclusion Valsartan and enalapril have effect for decreasing the BP in EH patients.