The coronary collateral circulation is an alternative source of blood supply to the myocardium jeopardized by failure of the original vessel to provide adequate flow. Angiogenesis growth factors induce angiogenesis to promote collateral circulation, been demonstrated in a number of different animal test and phase Ⅰ clinical experience to induce collateralization in the ischemic area and improve cardiac function. Although there are several unsolved questions, the pharmacologic use of angiogenesis growth factors will represent a viable therapeutic alternative for the patients with ischemic heart disease.

OBJECTIVE:To research the correlation between per capita disposable income,investment of pharmaceutical advertisement,people’s healthy level,pharmaceutical price and the demand of drugs in China METHODS:Based on the economical theory,the methods of the econometrics and the Eviews were adopted to establish the model of demand function RESULTS & CONCLUSION:Under the background of the non-full competition,the improvement of people’s living conditions can lead to the demand of drugs The changes of drug price have little influence on the demand of drugs

By generalizing the integrity crisis of college students,the article analyzes the causes of this phenomenon,and proposes a series of measures aiming at strengthening integrity education,establishing the favorable environment,completing the mechanism of rewards and punishments and building the credit system,in the hope of securing the deepening and full completion of good-faith education at college,both ideologically and systematically.

Aged ; Calcinosis ; complications ; Heart Aneurysm ; complications ; Heart Ventricles ; Humans ; Male ; Thrombosis ; complications

To explore the serum hepatocyte growth factor (HGF) lesion severity level and diabetic nephropathy (DN).A total of 207 patients with type 2 diabetes mellitus (T2DM) were recruited from Second Municipal Hospital.According to the level of urinary albumin excretion rate (UAER), they were divided into non-DN group (group A, n =56) : UAER ＜ 20 μg/min;early DN (group B, n =55) : UAER: 20-200 μg/min;clinical stage DN with normal renal function (group C, n =52):UAER ＞ 200 μg/min;DN in clinical renal dysfunction (group D, n =44) : UAER ＞ 200 μmol/min, decompensated chronic renal failure (serum creatinine: 133-177 μmol/L).And 55 healthy subjects were selected as controls.The serum levels of HGF, fasting plasma glucose , plasma glucose at 2 hour , blood urea nitrogen, creatinine and glycosylated hemoglobin were determined.HGF value : control group : (256.4 ± 30.4) ng/L,group A: (400.1 ±39.3)ng/L, group B: (689.4 ±55.6) ng/L, group C:(967.3 ±68.5) ng/L and group D: (150.7 ±23.2) ng/L.There are differences of serum HGF in different degree of DN.

Acupressure ; Acupuncture Points ; Child ; Child, Preschool ; Enuresis ; physiopathology ; therapy ; Female ; Humans ; Male ; Treatment Outcome ; Urination

AlM:To determine the relations between the changes of vascular endothelial growth factor ( VEGF ) concentration in plasma, aqueous humor and vitreous of patients with diabetic retinopathy ( DR ) and proliferative diabetic retinopathy ( PDR) , as well as to find if the condition of metabolism control of patients with DR may affect the VEGF level.
METHODS: Double antibody sandwich enzyme-linked immunosorbent assay was used to measure the levels of VEGF concentration in plasma of non-diabetic retinopathy ( NDR ) patients group, background diabetic retinopathy ( BDR ) patients group, and proliferative diabetic retinopathy ( PDR) patients group. The levels of HbAlc in plasma of patients in above three groups were measured at the same time. The VEGF concentration in aqueous humor, vitreous of PDR patients group and normal group was also measured for further comprehensive analysis. Human VEGF immunoassay Quantikine with high sensibility and quality was imported from R&D Co. LTD. , USA.
RESULTS: There was an increasing tendency in the VEGF concentration in aqueous humor of PDR patients group. There was no statistically significant difference as it was compared with normal group (P>0. 05). The VEGF concentration in vitreous of PDR patients group was obviously increased, there was significant difference as it was compared with normal group (P<0. 01). lt showed an increasing tendency of VEGF concentration in turn in plasma, aqueous humor and vitreous of the 3 PDR patients selves. lt showed that there was significant difference among VEGF concentration in plasma, aqueous humor and vitreous of all the PDR patients (P<0. 01). ln normal group there was no significant difference among VEGF concentration in plasma, aqueous humor and vitreous ( P > 0. 05 ). ln normal group the VEGF concentration in plasma was the highest, but in PDR patients group the VEGF concentration in vitreous was the highest.
CONCLUSlON: The significantly increased VEGF concentration in eyes, especially in vitreous of PDR patients may play an important role in development and deterioration of DR. lt was clear that VEGF played its normal biological functions mainly in plasma in normal human. ln severe DR patients, abnormal high may come from ischemic and VEGF concentration in vitreous suggested that it hypoxic retina and there was a tendency to diffuse towards the front of eyes.

Objective To investigate the characteristics of P3a and P3b which are the subcomponents of P300 event-related potential in patients with vascular cognitive impairment (VCI) ,and to investigate the relations between P3a,P3b and the changes of cognitive function and cerebral blood flow. Methods Thirty patients with VCI and twenty two normal subjects were tested for P3a and P3b cognitive function ischemic focus and cerebral blood flow and then analyzed for correlation. Results (1) The latency of P3a ((446 ± 71) ms, (429 ± 67) ms, (446±61)ms,(428±66)ms)and P3b((496 ±73)ms,(478 ±75)ms,(498 ±77)ms,(483 ±77)ms) was significantly prolonged in patients with VCI compared with that in normal subjects in all recorded regions(P<0.01) . The amplitude of P3a in patients with VCI ((3.3 ±2.6)μV,(3.3 ± 1.8)μV) was significantly lower than that in normal subjects in Fz and Pz (P<0.01) ,and the amplitude of P3b in patients with VCI((4.5 ±2.5)μV,(6.4 ± 3.8)μV,(5.3 ±3.8)μV,(5. 3 ±3.0)μV) was significantly lower than that in normal subjects in all recorded regions (P < 0.01 or P<0.05) . (2) The latency of P3a and P3b in patients with VCI was negatively related to the scores of sub items of attention and MMSE total scores (P < 0.05 or P < 0.01), the amplitude of P3a was positively related to the scores of MMSE total scores(P<0.05) ,the amplitude of P3b was positively related to the scores of attention and MMSE total scores(P<0.05). (3) The latency of P3a in patients with VCI was positively related to frontal lobe(P<0.05) ,and the latency of P3b was positively related to parietal lobe(P<0.05). (4) The latency of P3a in patients with VCI was positively related to RILMCA,RILACA and RIRACA(P<0.05 orP<0.01) ,the latency of P3b was positively related to RILMCA,RIRMCA and RIRACA(P<0.05 orP<0.01) ,and the amplitude of P3a was positively related to RILACA(P<0.01). Conclusion P3a and P3b are good objective indexes for testing the descent of cognitive function in patients with VCI,which can provide reference basis for the clinical diagnosis.

Objective To study the effectiveness of long-range electrocardio-monitoring system for aged people outside the hospital.Methods Long-range electrocardio-monitoring network system was adopted to perform monitoring 3 times every day for 320 retired leaders in Tianjin.Results The coincidence rate was 92.4%,and the morbidity rate 1.1%.Conclusion The long-range electrocardio monitoring network system can transfer patient's real-time information.Patients can be monitored by hospital at any time and in any place.

Asymptomatic bacteriuria is common in diabetic patients. This article reviews several aspects of asymptomatic bacteriuria in diabetes mellitus, including prevalence, mechanisms, coexisting risk factors, bacteriology, treatment and prognosis.