Objective To investigate the epidemiological characteristics of acute myocardial infarction (AMI) in Yichang City in the last 5 years, and to provide a basis for targeted prevention and treatment. Methods The annual estimated percentage was used to evaluate the trend of morbidity and mortality of AMI by using the monitoring data from 2015 to 2019 from the health big data platform of Yichang. Results There were 1 976 new cases of AMI in Yichang from 2015 to 2019, with a crude morbidity of 41.96/100 000, and standardized morbidity of 87.52/100 000. Among them the crude incidence rate in males was 57.69/100 000, and 29.84/100 000 in females. The difference was statistically significant (χ²=15.76, P<0.001). From 2015 to 2019, 1838 people died of AMI, with a crude mortality of 39.03/100,000 and a standardized morbidity of 27.27/100 000. The crude mortality for males and females was 44.03/100,000 and 3.39/100 000, respectively, and the difference was statistically significant (χ²=45.65, P<0.001). The morbidity and mortality of males and females were increased with age. Conclusion From 2015 to 2019, the morbidity of AMI in Yichang was at a moderately low level in China, but the mortality was higher than the national average. The morbidity showed an upward trend, with men and elderly people aged ≥60 being more serious. Appropriate intervention measures should be taken for different groups of people to reduce the incidence of AMI.