1.MRI and pathology comparative studies of leuko-araiosis
Jun WANG ; Xin REN ; Weidong ZHOU
Chinese Journal of Geriatrics 2015;34(8):914-917
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2.Clinical Evaluation on Ratio of Neutrophil-to-Lymphocyte in Different Pathogens
Dangli REN ; Haiyan HAN ; Xin ZHOU ; Jin LIU ; Ying JIN
Journal of Modern Laboratory Medicine 2017;32(2):102-105
Objective To investigate the clinical value of neutrophil-to-lymphocytc ratio(NLR) in identifying blood stream infection caused by different pathogens and for differentiating coagulase negative staphylococcus(CNS)bloodstream infection and contamination.Methods Medical records of 500 patients who underwent blood culture test and routine blood test at the same time were retrospectively analyzed,blood culture negative group 356 patients,blood culture positive group 144 patients,which included Gram-negative group,Gram positive group,fungi group,CNS bloodstream contamination and mingled group.Collected the results and calculated the NLR at the same time.NLR were applied by t test of each group.ROC curve was used to determine the cut off value of NLR.Results ①Mean values of NLR in negative blood culture,blood stream infection group,CNS bloodstream infection and contamination were 6.12,13.15,10.11 and 6.24.NLR had statistical difference between negative blood culture and blood stream infection group,CNS bloodstream infection group and contamination group (P<0.05).②Mean values of NLR in and fungi group were 15.33,11.63 and 10.58,respectively.NLR had statistical difference between Gram-positive bacteria group and Gram-negative bacteria group (P<0.05).NLR had no differences among Gram-positive bacteria (15.33) and Gram negative bacteria (11.63) compared with (10.58) fungi respectively (P>0.05).③The area under the curve of NLR predicting a positive blood culture,distinguishing Gram-positive bacteria and Gram-negative bacteria,differentiating CNS bloodstream infection and contamination were 0.86,0.60 and 0.75,respectively.The optimal cut off values of NLR for predicting a positive blood culture,distinguishing Gram-positive bacteria and Gramnegative bacteria,differentiating CNS bloodstream infection and contamination were 10.45,7.50 and 8.10 respectively.Conclusion NLR is highly effective in distinguishing blood stream infection and differentiating CNS bloodstream infection and contamination.
3.Application of color Doppler flow imaging in differentiating Graves′ disease (GD) from non-GD hyperthyroidism
Ren ZHOU ; Hai ZHANG ; Kuenneng TAN ; Yiling GUO ; Zhenfu XIN
Chinese Journal of Endocrinology and Metabolism 1985;0(02):-
I uptake of thyroid and color Doppler flow imaging (CDFI) of superior thyroid artery (STA) were performed in 20 patients with Graves′ disease (GD) and 19 patients with other causes of hyperthyroidism. Maximum velocity and diameter of STA in patients with GD were much higher than those in non-GD group. CDFI of STA seems to be a useful tool in differential diagnosis of hyperthyoidism.
4.Clinical study of irinotecan combined with 5-Fu/CF in the treatment of patients with advanced colorectal cancer
Qing REN ; Jingwu WU ; Ruihua XIONG ; Xin ZHOU
Cancer Research and Clinic 2011;23(1):28-30
Objective To evaluate the anti-tumor activity and toxicity of FOLFIRI regimen in the treatment of patients with advanced colorectal cancer. Methods 22 patients with advanced colorectal cancer used Irinotecan combined with 5-Fu/CF regimen to chemotherapy. Regimen: CPT-11 150 mg/m2 iv drip d1, CF 200 mg/m2 iv drip 2 h d1, 2; 5-Fu 400 mg/m2 iv drip d1, 2; 5-Fu 600 mg/m2 iv drip 22 h d1, 2. It is repeated every 2 weeks, two times a course. Efficiency and toxicity was evaluated after 4-6 cycles. Results Forty four patients were evaluated the efficiency. Two patients achieved CR, 16 PR, response rate was 40.9 %; MST was 11.3 months. TTP was 6.5 months. The main toxicity was cholinergic syndrome and delayed diarrhea,myelosuppression. There were no deaths during treatment. Conclusion The effectiveness of FOLFIRI regimen was higher and side effects was minor in advanced colorectal cancer. It should be further used and studied.
5.Diagnostic value of modified 6 hour-~(131)I uptake test in regard to the etiology of hyperthyroidism
Ren ZHOU ; Kunneng TAN ; Zelin LIU ; Yiling GUO ; Zhenfu XIN
Chinese Journal of Endocrinology and Metabolism 1985;0(02):-
~(131)I uptake by thyroid were assayed in 64 patients with Graves′ disease (GD) and 69 patients with non-GD hyperthyroidism. GD group had higher rate of ~(131)I uptake than non-GD group at 2, 6 and 24 h, and there was no overlap between the two groups at these 3 time points.~(131)I uptake at 2 and 6 h could differentiate GD fromlow ~(131)I uptakehyperthyroidism.
6.Mutation analysis of GJB3 and GJB4 genes in two patients with erythrokeratodermia variabilis
Xin ZHOU ; Jun REN ; Xin TIAN ; Yanhua LIANG ; Sanquan ZHANG ; Zhenming HUANG ; Xiaokun LIU ; Meihua CHEN
Chinese Journal of Dermatology 2012;45(2):129-130
ObjectiveTo detect the mutations of GJB3 and GJB4 genes in two sporadic cases of erythrokeratodermia variabilis(EKV).MethodsGenomic DNA was extracted from two sporadic patients with EKV,their family members,and 100 normal human controls.All the exons and adjacent splice sites of GJB3 and GJB4 genes were amplified by PCR.Mutation scanning was carried out via direct bidirectional DNA sequencing.ResultsA G134C mutation was found at the GJB3 gene in patient 1,which caused a substitution of glycine by alanine at codon 45 (G45A).No mutation was found in the GJB4 gene in case 1 or GJB3 and GJB4 genes in case 2.ConclusionA missence mutation G45A in GJB3 gene is found in a patient with EKV.
7.Clinical Characteristics of Solid Cystic Papillary Tumor in Children
xiang-yu, HOU ; xin-yuan, LI ; xin, ZHOU ; ke-ren, ZHANG
Journal of Applied Clinical Pediatrics 2006;0(20):-
Objective To explore clinical characteristics of diagnosis and treatment of solid-cystic papillary tumor(SCPT) of the pancreas in children.Methods There were retrospectively analyzed about the 7 patients treated in our hospital for SCPT,with the ave-rage age of 11.5 years.All patients complained abdominal pain following a trauma(71.4%) or overeating(28.6%).The main presentation was abdominal mass.Of the 7 patients,4 received distal pancreatectomy,2 pancreatico-duodenectomy,and 1 only biopsy.Results The nicks of all patients were primany hed.All patients were pathologically confirmed as SCPT after operation.All patients were followed up for 4 monthes to 4.5 years,the recent result was well.Conclusions SCPT is a low-grade malignant tumor,which is often asymptomatic,but the patients with symptoms generally suffer from an abdominal mass or abdominal pain.The prognosis is excellent after operation.
8.The CT findings of endobronchial spread in lung adenocarcinoma
Ping-Xin LV ; Xin-Hua ZHOU ; Bao-Jian LUO ; Xiao-Gang REN ;
Chinese Journal of Radiology 2001;0(05):-
Objective To analyze the CT findings of endobronchial spread in lung adenocarcinoma. Methods The CT findings of 15 lung adenocarcinomas or bronchioloalveolar carcinomas with endobronchial spread were reviewed,the distribution and the progression of the spread were evaluated.Results All of the primary tumors were consolidation form.The spread lesions distributed in one side of the lung or both sides along the bronchus.The pleural surface was spared.The CT findings of the spread included centrilobular nodules(n=5),tree-in-bud(n=7),acinar nodules(n=2),ground-glass opacities(n=10)and air- space consolidations(n=13)in the first CT examination.5 cases of the spread lesions only presented centrilobular nodules(single form)and 10 cases presented several appearances(complex form).All of the cases were diagnosed as tuberculosis or pneumonia,and antituberculotic or antibiotic therapy was taken with no effect.The follow-up CT scans showed progression in all cases,and the spread lesions with single form became multiple consolidations.The spread lesions with complex form deteriorated faster than the single one. Conclusion Although the CT findings of the endobronchial spread of the lung adenocarcinoma is specific, the clinical history and laboratory examination also are important for the differential diagnosis with tuberculosis and other infectious diseases.
9.Application of gene expression profiling in molecular classification, prognosis and therapy of B-cell lymphoma.
Zheng-rong MAO ; Ren ZHOU ; Xin-xia ZHANG ; Hans konrad MUELLER-HERMELINK ; Andreas ROSENWALD
Chinese Journal of Pathology 2009;38(11):785-789
Burkitt Lymphoma
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classification
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genetics
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therapy
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Gene Expression Profiling
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Gene Expression Regulation, Neoplastic
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell
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classification
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genetics
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therapy
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Lymphoma, B-Cell
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classification
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genetics
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therapy
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Lymphoma, Follicular
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classification
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genetics
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therapy
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Lymphoma, Large B-Cell, Diffuse
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classification
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genetics
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therapy
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Lymphoma, Mantle-Cell
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classification
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genetics
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therapy
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Prognosis
10.Correlation between epidermal growth factor receptor (EGFR) intron1 (CA) n microsatellite polymorphism, lymph node metastasis and expression of EGFR in non-small cell lung cancer.
Li ZHAO ; Xin JIANG ; Fang PENG ; Ren ZHOU
Chinese Journal of Pathology 2010;39(7):476-477
Adult
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Aged
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Aged, 80 and over
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Alleles
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Carcinoma, Non-Small-Cell Lung
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genetics
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metabolism
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pathology
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Dinucleotide Repeats
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genetics
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Female
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Humans
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Introns
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genetics
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Lung Neoplasms
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genetics
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metabolism
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pathology
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Lymphatic Metastasis
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Male
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Middle Aged
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Receptor, Epidermal Growth Factor
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genetics
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metabolism