Objective To investigate the clinical efficacy of Jiawei Guizhi Fuling Decoction combined with mifepristone on uterine fibroids and the changes of serum sex hormone levels in patients after treatment.MethodsForty-two patients were randomly divided into three groups: control group (42 cases) and control group (41 cases).The rats were treated with Guizhi Fuling Decoction plus mifepristone combination for three months.The control group was given only monotherapy with normal mifepristone tablets.The time of treatment was consistent with that of the study group.The levels of serum sex hormones were measured quantitatively before and after treatment.By comparing the therapeutic effect of the patients in different experimental groups and the levels of hormone Differences in evaluation between groups.ResultsThe total effective rate of 92.9% in the study group was significantly better than that in the control group (73.8%).The difference between the two groups was statistically significant (P<0.01).After treatment, the study group and the control group Uterine / tumor volume was significantly reduced, the difference was significantly different (P<0.01), compared between the two groups after treatment of uterine / tumor volume, the study group than the control group, the volume was significantly reduced, the difference was statistically significant (P<0.05).Serum levels of sex hormones: Serum levels of E2 and P were significantly lower in the study group than in the control group (P<0.05).Before and after treatment, the levels of serum E2 and P were lower in the two groups than before treatment (P<0.05).ConclusionJiawei Guizhi Fuling Decoction combined with mifepristone has a better effect on the treatment of uterine fibroids with mifepristone monotherapy, which significantly reduces the level of serum sex hormones and promotes the reduction of uterine / tumor volume after administration.It is worthy of promotion the combination of traditional Chinese and Western medicine conservative treatment of uterine fibroids means.

Objective:To investigate the efficacy and safety of metformin in the treatment of elderly patients with diabetes. Meth-ods:Totally 72 cases of elderly patients with diabetes in our hospital from January 2012 to December 2012 were randomly divided into the observation group and the control group. The observation group was received metformin, and the control group was given repaglin-ide. The efficacy and safety of the two groups were compared. Results:After the treatment, blood sugar of fasting, 2h after meals and 10:00 p. m. in the observation group and the control group was significantly decreased (P<0. 05), and blood sugar of fasting in the observation group was significantly lower than that in the control (P<0. 05), while that of the other time points was without significant difference (P>0. 05). The HbA1c levels before and after the treatment in the observation group was with statistically significant differ-ence (P<0. 05), and those in the control group was without significant difference (P>0. 05). The incidence of adverse reactions in the observation group was lower than that in the control group(P<0. 05). Conclusion:Effect of metformin in the treatment of elderly patients with diabetes is remarkable and safe, which is worthy of further promotion and application.

Objective:To evaluate the efficacy and safety of controlled-release dinoprostone pessary(propess) in cervical ripening and intermediate labor induction.Methods:Eighty primiparas with uterogestation and Bishop score ≤6 points and no vaginal delivery taboo were equally divided into a study and a control group.The former received intravaginal administration of propess and the latter intravenous injection of low-dose oxytocin by the randomized control method.Comparisons were made of the Bishop score,delivery and the state of the fetuses and neonates between the two groups.The side effects of propess were observed.Results:Bishop scores were 7.75?2.227 and 6.38?2.862 in the study and the control group respectively 12 hours after the medication,significantly higher than 4.23?1.025 and 4.15?1.099 before the induction(P 0.05).The major side effect of propess was the over-frequent and over-strong contraction of the uterine,which occurred in 2 cases in the study group but subsided after its removal.Conclusion:Dinoprostone pessary,effective,safe and convenient,is obviously superior to oxytocin in cervical ripening and labor induction.

Objective To explore the upstream signal transduction pathway of neutrophil elastase(NE)-induced mucin(MUC)5AC gene expression.Methods A549 cells were either incubated with NE alone or with DMTU,aprotinin or AG1478.The level of MUC5AC mRNA was measured with RT-PCR.The activation of epidermal growth factor receptor(EGFR) and signaling were assessed by measuring the release of epidermal growth factor(EGF) and the phosphorylation of EGFR.Results NE increased MUC5AC gene expression accompanied by an increase of EGF and phosphorylated EGFR.DMTU,aprotinin and AG1478 significantly inhibited MUC5AC gene expression.DMTU and aprotinin significantly decreased the level of EGF and phosphorylated EGFR.ConclusionNE can induce MUC5AC gene expression via EGFR signalling in A549 cells.The upper stream involves oxidants,activation of tissue kallikrein and EGF.

OBJECTIVE To cultivate central supply unit member's custom of watching detail and dealing with everything carefully. To enhance central supply unit work's quality and efficiency,and decrease the phenomenon of article sterilized overdue and nipping tool's scathe. METHODS To organize study and enhance the cognition. To constitute regulations,systems and operation rule. To investigate the condition of medical instrument utilized,and pay attention to detail service for packaging sterilization. RESULTS The rate of overdue sterilized article decreased from 0.008% to 0.001%. The number of nipping tool's injuries decreased from 18 in 24 to 2 in 22 when the detail management was actualized. The rate of injury decreased from 75.0% to 9.09%. CONCLUSIONS In order to ensure the quality of asepsis of articles,we need to alter our conceptions,strengthen our responsibility,servicing more initiatively and carefulness.

Objective:To investigate the clinical value of electrocardiogram in risk stratification of patients with non-ST segment elevation acute coronary syndrome(ACS).Methods: According to the change of electrocardiogram, 260 patients with non-ST segment elevation ACS were divided into four groups: ECG-undiagnosed group (n=22), T-wave inversion group (ST-segment depression group), ST-segment depression group (n=118) and normal electrocardiogram group(n=80). All patients were treated with conventional 18-lead electrocardiogram and troponin I(TnI)detection in the four groups. The incidence of cardiovascular events during and after hospitalization was observed. Results: The complex cardiovascular events and recurrent angina attacks in ST segment depression group increased significantly than that in normal ECG group. The difference was statistically significant (x2=5.723,x2=15.680;P<0.05). Multivariate logistic regression analysis showed that TnI positive factors predict the independent value of composite cardiovascular events higher.Conclusion:The patients with ST segment elevation acute coronary syndrome can effectively carry out risk stratification by ECG ST-segment changes and TnI levels, and predict the cardiovascular events. It has higher clinical application value and independent predictive value of TnI positive.

The author in this text discusses the right of replicating medical records from the angle of law,and puts forward his own viewpoint,that is for the objective medical records,patients can copy them in any time,but for the subjective ones,it just depends on the cases. Generally speaking patients don't have the copy right about them,but when medical treatment trouble occurs,the patients should have the copy right to copy the sealed and stored medical records.

Independent institute is a new-rising education mode.With the steady development of independent institute,it is vital to uphold teaching-centered principle,define reasonable education objectives,deepen teaching reform,and innovate teaching management mechanism so as to guarantee its education quality and demonstrate its characteristics.

With the development of modern medical technology,the traditional teaching mode can not satisfy the teaching requirements of biomedical measurement and instrument which is one of the main courses of biomedical engineering,and network teaching is the tendency.The article studies how to develop biomedical measurement and instrument's network teaching from many aspects,such as the construction of information platform,network teaching pattern design and so on,and the practice has achieved good results.

Human resources management as the core factors affects the development of hospital library. The management should con-sider people -oriented theory, integrate harmonious management and concept innovation, and pay more attention to development and uti-lization of human resources, so as to ensure staffs would play an important role in hospital library modernization construction and sustain-able development.